Structure and Function of the RedJ Protein, a Thioesterase from the Prodiginine Biosynthetic Pathway in Streptomyces coelicolor

Prodiginines are a class of red-pigmented natural products with immunosuppressant, anticancer, and antimalarial activities. Recent studies on prodiginine biosynthesis in Streptomyces coelicolor have elucidated the function of many enzymes within the pathway. However, the function of RedJ, which was...

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Veröffentlicht in:	The Journal of biological chemistry 2011-06, Vol.286 (25), p.22558-22569
Hauptverfasser:	Whicher, Jonathan R., Florova, Galina, Sydor, Paulina K., Singh, Renu, Alhamadsheh, Mamoun, Challis, Gregory L., Reynolds, Kevin A., Smith, Janet L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer Drug Bacterial Metabolism BASIC BIOLOGICAL SCIENCES BIOSYNTHESIS CARBOXYLIC ACIDS Catalytic Domain CRYSTAL STRUCTURE CRYSTALLIZATION CRYSTALLOGRAPHY Crystallography, X-Ray EFFICIENCY Enzyme Kinetics ENZYMES Gene Knockout GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE GENES Immunosupressor KINETICS METABOLISM Models, Molecular Natural Product Biosynthesis Prodigiosin - analogs & derivatives Prodigiosin - biosynthesis PRODUCTION PROTEIN STRUCTURE PROTEINS RESOLUTION Sequence Deletion STREPTOMYCES Streptomyces coelicolor - enzymology Streptomyces coelicolor - genetics Streptomyces coelicolor - metabolism Substrate Specificity SUBSTRATES Thiolester Hydrolases - chemistry Thiolester Hydrolases - genetics Thiolester Hydrolases - metabolism
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