PDGFRβ Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development

Mural cells (pericytes and vascular smooth muscle cells) provide trophic and structural support to blood vessels. Vascular smooth muscle cells alternate between a synthetic/proliferative state and a differentiated/contractile state, but the dynamic states of pericytes are poorly understood. To explo...

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Veröffentlicht in:	Developmental cell 2011-06, Vol.20 (6), p.815-826
Hauptverfasser:	Olson, Lorin E., Soriano, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes, White - cytology Adipocytes, White - metabolism Animals Biological and medical sciences Brain - cytology Brain - immunology Brain - metabolism Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell Proliferation Cells, Cultured Cytokines - metabolism Female Flow Cytometry Fundamental and applied biological sciences. Psychology Gene Knock-In Techniques Homeostasis Integrases - metabolism Mesoderm - cytology Mesoderm - metabolism Mice Mice, Inbred C57BL Molecular and cellular biology Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Pericytes - cytology Pericytes - metabolism Phenotype Receptor, Platelet-Derived Growth Factor beta - physiology
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