Feasibility of deformation-independent tumor-tracking radiotherapy during respiration

To evaluate the feasibility of tumor-tracking radiotherapy that does not consider tumor deformation during respiration. Four-dimensional computed tomography (4D-CT) data, which considers 10 phases of the respiration cycle, were acquired in 4 patients with lung cancer and 4 patients with liver cancer...

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Veröffentlicht in:Journal of medical physics 2011-04, Vol.36 (2), p.78-84
Hauptverfasser: Kim, Seonkyu, Yoon, Myonggeun, Shin, Dong Ho, Kim, Dongwook, Lee, Sangyeob, Lee, Se Byeong, Park, Sung Yong, Song, Sang Hyuk
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container_issue 2
container_start_page 78
container_title Journal of medical physics
container_volume 36
creator Kim, Seonkyu
Yoon, Myonggeun
Shin, Dong Ho
Kim, Dongwook
Lee, Sangyeob
Lee, Se Byeong
Park, Sung Yong
Song, Sang Hyuk
description To evaluate the feasibility of tumor-tracking radiotherapy that does not consider tumor deformation during respiration. Four-dimensional computed tomography (4D-CT) data, which considers 10 phases of the respiration cycle, were acquired in 4 patients with lung cancer and 4 patients with liver cancer. Initial treatment plans were established at the end of the inhalation phase (phase 1). As a simulation of deformation-free tumor-tracking radiotherapy, the beam center of the initial plan was moved to the tumor center for all other phases, and the tumor shape acquired from phase 1 was used for all 10 phases. The feasibility of this method was analyzed based on assessment of equivalent uniform dose (EUD), homogeneity index (HI) and coverage index (COV). In photon radiation treatment, movement-induced dose reduction was not particularly significant, with 0.5%, 17.3% and 2.8% average variation in EUD, HI and COV, respectively. In proton radiation treatment, movement-induced dose reduction was more significant, with 0.3%, 40.5% and 2.2% average variation in EUD, HI and COV, respectively. Proton treatment is more sensitive to tumor movement than is photon treatment, and that it is reasonable to disregard tumor deformation during photon therapy employing tumor-tracking radiotherapy.
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Four-dimensional computed tomography (4D-CT) data, which considers 10 phases of the respiration cycle, were acquired in 4 patients with lung cancer and 4 patients with liver cancer. Initial treatment plans were established at the end of the inhalation phase (phase 1). As a simulation of deformation-free tumor-tracking radiotherapy, the beam center of the initial plan was moved to the tumor center for all other phases, and the tumor shape acquired from phase 1 was used for all 10 phases. The feasibility of this method was analyzed based on assessment of equivalent uniform dose (EUD), homogeneity index (HI) and coverage index (COV). In photon radiation treatment, movement-induced dose reduction was not particularly significant, with 0.5%, 17.3% and 2.8% average variation in EUD, HI and COV, respectively. In proton radiation treatment, movement-induced dose reduction was more significant, with 0.3%, 40.5% and 2.2% average variation in EUD, HI and COV, respectively. 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subjects Breast cancer
Cancer therapies
Medical imaging
Methods
Original
Radiation
Radiation therapy
Simulation
Tomography
Tumors
title Feasibility of deformation-independent tumor-tracking radiotherapy during respiration
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