Systematizing the generation of missing metabolic knowledge

Genome-scale metabolic network reconstructions are built from all of the known metabolic reactions and genes in a target organism. However, since our knowledge of any organism is incomplete, these network reconstructions contain gaps. Reactions may be missing, resulting in dead-ends in pathways, whi...

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Veröffentlicht in:	Biotechnology and bioengineering 2010-10, Vol.107 (3), p.403-412
Hauptverfasser:	Orth, Jeffrey D, Palsson, Bernhard Ø
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomedical Research - methods Biotechnology Computation Computational mathematics Fundamental and applied biological sciences. Psychology gap-filling Gaps gene annotation General aspects Genes Genetics Genomics Genotype & phenotype growmatch Mathematical models Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) metabolic network reconstruction Metabolic Networks and Pathways Metabolism Metabolome Networks Organisms Reconstruction SMILEY Systems Biology
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