Sequence Analysis of the gag-pol Gene of Human Immunodeficiency Virus Type 1 of Intersubtype (B'/C) Recombinant Strain in Beijing, China
Little is known about the molecular and biological properties of HIV-1 intersubtype B'/C in Beijing. To fill the gap, we sequenced and analyzed the gag-pol genes from 39 HIV-1 B'/C recombinant infectors in Beijing, China during 2007. The results show that 36 CRF07_BC and 2 CRF08_BC isolate...
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| Veröffentlicht in: | AIDS research and human retroviruses 2011-03, Vol.27 (3), p.331-337 |
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| creator | YE, Jing-Rong XIN, Ruo-Lei BAI, Li-Shi LU, Hong-Yan YU, Shuang-Qing YI ZENG |
| description | Little is known about the molecular and biological properties of HIV-1 intersubtype B'/C in Beijing. To fill the gap, we sequenced and analyzed the gag-pol genes from 39 HIV-1 B'/C recombinant infectors in Beijing, China during 2007. The results show that 36 CRF07_BC and 2 CRF08_BC isolates have a structural profile identical or nearly identical to CRF07_BC or CRF08_BC according to sequences in the gag-pol regions. The CRF07_BC circulating in injecting drug users (IDUs) and heterosexuals forms a diverse phylogenetic tree and most isolates from homosexuals cluster together. However, all the B'/C recombinant strains were remarkable for their low interpatient diversity in gag-pol genes (3.1, 3.0, and 2.2% for isolates from IDUs, heterosexuals, and homosexuals, respectively). We identified I7V, E91G, N242T, and K361R in the gag gene and R290I (HXB2 positions) in the pol gene as signature amino acid substitutions characteristic of HIV-1 CRF07_BC from the Beijing lineage. In addition, one new B'/C recombinant was detected. These results may contribute to an understanding of HIV-1 in Beijing. |
| doi_str_mv | 10.1089/aid.2010.0186 |
| format | Article |
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To fill the gap, we sequenced and analyzed the gag-pol genes from 39 HIV-1 B'/C recombinant infectors in Beijing, China during 2007. The results show that 36 CRF07_BC and 2 CRF08_BC isolates have a structural profile identical or nearly identical to CRF07_BC or CRF08_BC according to sequences in the gag-pol regions. The CRF07_BC circulating in injecting drug users (IDUs) and heterosexuals forms a diverse phylogenetic tree and most isolates from homosexuals cluster together. However, all the B'/C recombinant strains were remarkable for their low interpatient diversity in gag-pol genes (3.1, 3.0, and 2.2% for isolates from IDUs, heterosexuals, and homosexuals, respectively). We identified I7V, E91G, N242T, and K361R in the gag gene and R290I (HXB2 positions) in the pol gene as signature amino acid substitutions characteristic of HIV-1 CRF07_BC from the Beijing lineage. In addition, one new B'/C recombinant was detected. These results may contribute to an understanding of HIV-1 in Beijing.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/aid.2010.0186</identifier><identifier>PMID: 20950146</identifier><identifier>CODEN: ARHRE7</identifier><language>eng</language><publisher>New Rochelle, NY: Liebert</publisher><subject>Adult ; AIDS/HIV ; Biological and medical sciences ; China ; Diagnosis ; DNA, Viral - genetics ; Drug Users ; Female ; Fundamental and applied biological sciences. 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To fill the gap, we sequenced and analyzed the gag-pol genes from 39 HIV-1 B'/C recombinant infectors in Beijing, China during 2007. The results show that 36 CRF07_BC and 2 CRF08_BC isolates have a structural profile identical or nearly identical to CRF07_BC or CRF08_BC according to sequences in the gag-pol regions. The CRF07_BC circulating in injecting drug users (IDUs) and heterosexuals forms a diverse phylogenetic tree and most isolates from homosexuals cluster together. However, all the B'/C recombinant strains were remarkable for their low interpatient diversity in gag-pol genes (3.1, 3.0, and 2.2% for isolates from IDUs, heterosexuals, and homosexuals, respectively). We identified I7V, E91G, N242T, and K361R in the gag gene and R290I (HXB2 positions) in the pol gene as signature amino acid substitutions characteristic of HIV-1 CRF07_BC from the Beijing lineage. In addition, one new B'/C recombinant was detected. 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Psychology</subject><subject>Gays</subject><subject>Genes</subject><subject>Genes, gag - genetics</subject><subject>Genes, pol - genetics</subject><subject>Genetic Variation</subject><subject>Health aspects</subject><subject>Heterosexuality</subject><subject>HIV infection</subject><subject>HIV-1 - classification</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - isolation & purification</subject><subject>Homosexuality</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Phylogeny</subject><subject>Physiological aspects</subject><subject>Polymerase chain reaction</subject><subject>Prevention</subject><subject>Retrovirus</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Risk factors</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Notes</subject><subject>Viral diseases</subject><subject>Virology</subject><subject>Young Adult</subject><issn>0889-2229</issn><issn>1931-8405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkm1rFDEQxxdR7Fl96VsJiFTBveZhH5I3wvXQ9qAg2OrbkE0meym7ybnZFe4b-LHNcme1IEgCYWZ-M8lM_ln2kuAlwVycK2eWFCcLE149yhZEMJLzApePswXmXOSUUnGSPYvxDmMsKC2fZicUixKTolpkP2_g-wReA1p51e2jiyhYNG4BtarNd6FDl-Bh9l1NvfJo0_eTDwas0y6l7dE3N0wR3e53gMiMbfwIQ5yacfa8vTg7X79DX0CHvnFe-RHdjINyHqV9Ae7O-fY9Wm9T6Hn2xKouwovjeZp9_fTxdn2VX3--3KxX17kuSTnmtFTUGqgqXVijCQFrseCqANsYJoA3wJmCmlDWcGM1ENoYY0raFBoKIjQ7zT4c6u6mpgejwacHdXI3uF4NexmUkw8j3m1lG35IRtJoaZUKnB0LDCGNLo6yd1FD1ykPYYqSV7TmFWPi_2RZ1VVdC5bI1weyVR1I521IV-uZlita0qKoqaCJWv6DSstA73Tw6VOS_0FCfkjQQ4hxAHvfJsFyVo9M6pGzeuSsnsS_-ns29_RvuSTgzRFQUavODsprF_9wTKSGGGW_AC_Nzcc</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>YE, Jing-Rong</creator><creator>XIN, Ruo-Lei</creator><creator>BAI, Li-Shi</creator><creator>LU, Hong-Yan</creator><creator>YU, Shuang-Qing</creator><creator>YI ZENG</creator><general>Liebert</general><general>Mary Ann Liebert, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7T5</scope><scope>7T7</scope><scope>7U2</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20110301</creationdate><title>Sequence Analysis of the gag-pol Gene of Human Immunodeficiency Virus Type 1 of Intersubtype (B'/C) Recombinant Strain in Beijing, China</title><author>YE, Jing-Rong ; XIN, Ruo-Lei ; BAI, Li-Shi ; LU, Hong-Yan ; YU, Shuang-Qing ; YI ZENG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-25a2fde66c4fdc11eff098a4efbd39e8be83ae7123b8dfce12bddd52b4ce419c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>China</topic><topic>Diagnosis</topic><topic>DNA, Viral - genetics</topic><topic>Drug Users</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gays</topic><topic>Genes</topic><topic>Genes, gag - genetics</topic><topic>Genes, pol - genetics</topic><topic>Genetic Variation</topic><topic>Health aspects</topic><topic>Heterosexuality</topic><topic>HIV infection</topic><topic>HIV-1 - classification</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - isolation & purification</topic><topic>Homosexuality</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Molecular Sequence Data</topic><topic>Phylogeny</topic><topic>Physiological aspects</topic><topic>Polymerase chain reaction</topic><topic>Prevention</topic><topic>Retrovirus</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Risk factors</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Notes</topic><topic>Viral diseases</topic><topic>Virology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YE, Jing-Rong</creatorcontrib><creatorcontrib>XIN, Ruo-Lei</creatorcontrib><creatorcontrib>BAI, Li-Shi</creatorcontrib><creatorcontrib>LU, Hong-Yan</creatorcontrib><creatorcontrib>YU, Shuang-Qing</creatorcontrib><creatorcontrib>YI ZENG</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Safety Science and Risk</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>AIDS research and human retroviruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YE, Jing-Rong</au><au>XIN, Ruo-Lei</au><au>BAI, Li-Shi</au><au>LU, Hong-Yan</au><au>YU, Shuang-Qing</au><au>YI ZENG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sequence Analysis of the gag-pol Gene of Human Immunodeficiency Virus Type 1 of Intersubtype (B'/C) Recombinant Strain in Beijing, China</atitle><jtitle>AIDS research and human retroviruses</jtitle><addtitle>AIDS Res Hum Retroviruses</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>27</volume><issue>3</issue><spage>331</spage><epage>337</epage><pages>331-337</pages><issn>0889-2229</issn><eissn>1931-8405</eissn><coden>ARHRE7</coden><abstract>Little is known about the molecular and biological properties of HIV-1 intersubtype B'/C in Beijing. To fill the gap, we sequenced and analyzed the gag-pol genes from 39 HIV-1 B'/C recombinant infectors in Beijing, China during 2007. The results show that 36 CRF07_BC and 2 CRF08_BC isolates have a structural profile identical or nearly identical to CRF07_BC or CRF08_BC according to sequences in the gag-pol regions. The CRF07_BC circulating in injecting drug users (IDUs) and heterosexuals forms a diverse phylogenetic tree and most isolates from homosexuals cluster together. However, all the B'/C recombinant strains were remarkable for their low interpatient diversity in gag-pol genes (3.1, 3.0, and 2.2% for isolates from IDUs, heterosexuals, and homosexuals, respectively). We identified I7V, E91G, N242T, and K361R in the gag gene and R290I (HXB2 positions) in the pol gene as signature amino acid substitutions characteristic of HIV-1 CRF07_BC from the Beijing lineage. In addition, one new B'/C recombinant was detected. These results may contribute to an understanding of HIV-1 in Beijing.</abstract><cop>New Rochelle, NY</cop><pub>Liebert</pub><pmid>20950146</pmid><doi>10.1089/aid.2010.0186</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | Adult AIDS/HIV Biological and medical sciences China Diagnosis DNA, Viral - genetics Drug Users Female Fundamental and applied biological sciences. Psychology Gays Genes Genes, gag - genetics Genes, pol - genetics Genetic Variation Health aspects Heterosexuality HIV infection HIV-1 - classification HIV-1 - genetics HIV-1 - isolation & purification Homosexuality Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Molecular Sequence Data Phylogeny Physiological aspects Polymerase chain reaction Prevention Retrovirus Reverse Transcriptase Polymerase Chain Reaction Risk factors Sequence Analysis, DNA Sequence Notes Viral diseases Virology Young Adult |
| title | Sequence Analysis of the gag-pol Gene of Human Immunodeficiency Virus Type 1 of Intersubtype (B'/C) Recombinant Strain in Beijing, China |
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