Evaluation of acute toxicity and hepatoprotective activity of the methanolic extract of Dichrostachys cinerea (Wight and Arn.) leaves
D. cinerea are the chief source of drug compounds that are active against various ailments such as jaundice, inflammations rheumatism, fever, asthma, body ache, chest problems, toothache, ulcers, wounds, eye diseases and have an aphrodisiac property. In present study, It was aimed to test the hepato...
Gespeichert in:
| Veröffentlicht in: | Pharmacognosy research 2011-01, Vol.3 (1), p.40-43 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 43 |
|---|---|
| container_issue | 1 |
| container_start_page | 40 |
| container_title | Pharmacognosy research |
| container_volume | 3 |
| creator | Babu, P Suresh Krishna, V Maruthi, K R Shankarmurthy, K Babu, Ramesh K |
| description | D. cinerea are the chief source of drug compounds that are active against various ailments such as jaundice, inflammations rheumatism, fever, asthma, body ache, chest problems, toothache, ulcers, wounds, eye diseases and have an aphrodisiac property. In present study, It was aimed to test the hepatoprotective activity of the plant.
The methanolic extract of Dichrostachys cinerea (Mimoseae) leaves was subjected to evaluation of acute toxicity and hepatoprotective property, using albino mice and rats. The parameters for estimation of liver function, based on serum markers such as total bilirubin, total protein, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase with histopathological profile of the liver tissue, were studied consequently.
The methanolic extract did not show any mortality up to a dose of 3500 mg/kg body weight. The methanolic extract showed significant hepatoprotectivity. The histopathological profile of the drug-treated liver tissue demonstrated similar morphology as that of controls.
Methanolic extract of Dichrostachys cinerea was found to have significant hepatoprotective activity. |
| doi_str_mv | 10.4103/0974-8490.79114 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3119270</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A254151455</galeid><sourcerecordid>A254151455</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-ccdd7deadab4211a4f5adc9f9744630d2bf9192fbb80c63cb64e0d479452a25d3</originalsourceid><addsrcrecordid>eNpdkstqGzEUhofS0IQ06-yKoIumCzvSjOQZbQomTS8Q6KalS3FGOuNRGEuupDHxA_S9q3ES40abI_R_-jm3orhkdM4Zra6prPms4ZLOa8kYf1WcHV5eH91Pi4sY72k-lSwlZ2-K05LVFaskPyv-3m5hGCFZ74jvCOgxIUn-wWqbdgScIT1uIPlN8Al1slvMTA6TmvnUI1lj6sH5wWqCDylkeVI-W90HHxPofheJtg4DArn6bVd92vsug5t_JAPCFuPb4qSDIeLFUzwvfn25_XnzbXb34-v3m-XdTHPepJnWxtQGwUDLS8aAdwKMll2ulC8qasq2k0yWXds2VC8q3S44UsNryUUJpTDVefHp0Xcztms0Gl3Od1CbYNcQdsqDVf8rzvZq5beqYtm3ptngw5NB8H9GjEmtbdQ4DODQj1E1tcgdr_fk-xfkvR-Dy9Up1ixqIRrRHFErGFBZ1_mpgZOnWpaCM8G4EJm6fqR07mgM2B0yZlRNq6CmYatp2Gq_CvnHu-NCD_zz4Kt_CouweQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1867558580</pqid></control><display><type>article</type><title>Evaluation of acute toxicity and hepatoprotective activity of the methanolic extract of Dichrostachys cinerea (Wight and Arn.) leaves</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Babu, P Suresh ; Krishna, V ; Maruthi, K R ; Shankarmurthy, K ; Babu, Ramesh K</creator><creatorcontrib>Babu, P Suresh ; Krishna, V ; Maruthi, K R ; Shankarmurthy, K ; Babu, Ramesh K</creatorcontrib><description>D. cinerea are the chief source of drug compounds that are active against various ailments such as jaundice, inflammations rheumatism, fever, asthma, body ache, chest problems, toothache, ulcers, wounds, eye diseases and have an aphrodisiac property. In present study, It was aimed to test the hepatoprotective activity of the plant.
The methanolic extract of Dichrostachys cinerea (Mimoseae) leaves was subjected to evaluation of acute toxicity and hepatoprotective property, using albino mice and rats. The parameters for estimation of liver function, based on serum markers such as total bilirubin, total protein, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase with histopathological profile of the liver tissue, were studied consequently.
The methanolic extract did not show any mortality up to a dose of 3500 mg/kg body weight. The methanolic extract showed significant hepatoprotectivity. The histopathological profile of the drug-treated liver tissue demonstrated similar morphology as that of controls.
Methanolic extract of Dichrostachys cinerea was found to have significant hepatoprotective activity.</description><identifier>ISSN: 0974-8490</identifier><identifier>ISSN: 0976-4836</identifier><identifier>EISSN: 0974-8490</identifier><identifier>DOI: 10.4103/0974-8490.79114</identifier><identifier>PMID: 21731394</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Albinism ; Animals ; Beans ; Chemical properties ; Cytochrome ; Drug dosages ; Endoplasmic reticulum ; Enzymes ; Free radicals ; Health aspects ; Legumes ; Lipids ; Liver diseases ; Materia medica, Vegetable ; Metabolism ; Methanol ; Mimosaceae ; Original ; Pharmacy ; Plant extracts ; Prevention ; Proteins ; Risk factors ; Rodents ; Statistical analysis ; Studies ; Toxicity ; Variance analysis</subject><ispartof>Pharmacognosy research, 2011-01, Vol.3 (1), p.40-43</ispartof><rights>COPYRIGHT 2011 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Jan-Mar 2011</rights><rights>Copyright: © Pharmacognosy Research 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-ccdd7deadab4211a4f5adc9f9744630d2bf9192fbb80c63cb64e0d479452a25d3</citedby><cites>FETCH-LOGICAL-c448t-ccdd7deadab4211a4f5adc9f9744630d2bf9192fbb80c63cb64e0d479452a25d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119270/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119270/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21731394$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Babu, P Suresh</creatorcontrib><creatorcontrib>Krishna, V</creatorcontrib><creatorcontrib>Maruthi, K R</creatorcontrib><creatorcontrib>Shankarmurthy, K</creatorcontrib><creatorcontrib>Babu, Ramesh K</creatorcontrib><title>Evaluation of acute toxicity and hepatoprotective activity of the methanolic extract of Dichrostachys cinerea (Wight and Arn.) leaves</title><title>Pharmacognosy research</title><addtitle>Pharmacognosy Res</addtitle><description>D. cinerea are the chief source of drug compounds that are active against various ailments such as jaundice, inflammations rheumatism, fever, asthma, body ache, chest problems, toothache, ulcers, wounds, eye diseases and have an aphrodisiac property. In present study, It was aimed to test the hepatoprotective activity of the plant.
The methanolic extract of Dichrostachys cinerea (Mimoseae) leaves was subjected to evaluation of acute toxicity and hepatoprotective property, using albino mice and rats. The parameters for estimation of liver function, based on serum markers such as total bilirubin, total protein, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase with histopathological profile of the liver tissue, were studied consequently.
The methanolic extract did not show any mortality up to a dose of 3500 mg/kg body weight. The methanolic extract showed significant hepatoprotectivity. The histopathological profile of the drug-treated liver tissue demonstrated similar morphology as that of controls.
Methanolic extract of Dichrostachys cinerea was found to have significant hepatoprotective activity.</description><subject>Albinism</subject><subject>Animals</subject><subject>Beans</subject><subject>Chemical properties</subject><subject>Cytochrome</subject><subject>Drug dosages</subject><subject>Endoplasmic reticulum</subject><subject>Enzymes</subject><subject>Free radicals</subject><subject>Health aspects</subject><subject>Legumes</subject><subject>Lipids</subject><subject>Liver diseases</subject><subject>Materia medica, Vegetable</subject><subject>Metabolism</subject><subject>Methanol</subject><subject>Mimosaceae</subject><subject>Original</subject><subject>Pharmacy</subject><subject>Plant extracts</subject><subject>Prevention</subject><subject>Proteins</subject><subject>Risk factors</subject><subject>Rodents</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Toxicity</subject><subject>Variance analysis</subject><issn>0974-8490</issn><issn>0976-4836</issn><issn>0974-8490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkstqGzEUhofS0IQ06-yKoIumCzvSjOQZbQomTS8Q6KalS3FGOuNRGEuupDHxA_S9q3ES40abI_R_-jm3orhkdM4Zra6prPms4ZLOa8kYf1WcHV5eH91Pi4sY72k-lSwlZ2-K05LVFaskPyv-3m5hGCFZ74jvCOgxIUn-wWqbdgScIT1uIPlN8Al1slvMTA6TmvnUI1lj6sH5wWqCDylkeVI-W90HHxPofheJtg4DArn6bVd92vsug5t_JAPCFuPb4qSDIeLFUzwvfn25_XnzbXb34-v3m-XdTHPepJnWxtQGwUDLS8aAdwKMll2ulC8qasq2k0yWXds2VC8q3S44UsNryUUJpTDVefHp0Xcztms0Gl3Od1CbYNcQdsqDVf8rzvZq5beqYtm3ptngw5NB8H9GjEmtbdQ4DODQj1E1tcgdr_fk-xfkvR-Dy9Up1ixqIRrRHFErGFBZ1_mpgZOnWpaCM8G4EJm6fqR07mgM2B0yZlRNq6CmYatp2Gq_CvnHu-NCD_zz4Kt_CouweQ</recordid><startdate>201101</startdate><enddate>201101</enddate><creator>Babu, P Suresh</creator><creator>Krishna, V</creator><creator>Maruthi, K R</creator><creator>Shankarmurthy, K</creator><creator>Babu, Ramesh K</creator><general>Medknow Publications and Media Pvt. Ltd</general><general>Phcog.net</general><general>Medknow Publications Pvt Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201101</creationdate><title>Evaluation of acute toxicity and hepatoprotective activity of the methanolic extract of Dichrostachys cinerea (Wight and Arn.) leaves</title><author>Babu, P Suresh ; Krishna, V ; Maruthi, K R ; Shankarmurthy, K ; Babu, Ramesh K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-ccdd7deadab4211a4f5adc9f9744630d2bf9192fbb80c63cb64e0d479452a25d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Albinism</topic><topic>Animals</topic><topic>Beans</topic><topic>Chemical properties</topic><topic>Cytochrome</topic><topic>Drug dosages</topic><topic>Endoplasmic reticulum</topic><topic>Enzymes</topic><topic>Free radicals</topic><topic>Health aspects</topic><topic>Legumes</topic><topic>Lipids</topic><topic>Liver diseases</topic><topic>Materia medica, Vegetable</topic><topic>Metabolism</topic><topic>Methanol</topic><topic>Mimosaceae</topic><topic>Original</topic><topic>Pharmacy</topic><topic>Plant extracts</topic><topic>Prevention</topic><topic>Proteins</topic><topic>Risk factors</topic><topic>Rodents</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Toxicity</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Babu, P Suresh</creatorcontrib><creatorcontrib>Krishna, V</creatorcontrib><creatorcontrib>Maruthi, K R</creatorcontrib><creatorcontrib>Shankarmurthy, K</creatorcontrib><creatorcontrib>Babu, Ramesh K</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pharmacognosy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Babu, P Suresh</au><au>Krishna, V</au><au>Maruthi, K R</au><au>Shankarmurthy, K</au><au>Babu, Ramesh K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of acute toxicity and hepatoprotective activity of the methanolic extract of Dichrostachys cinerea (Wight and Arn.) leaves</atitle><jtitle>Pharmacognosy research</jtitle><addtitle>Pharmacognosy Res</addtitle><date>2011-01</date><risdate>2011</risdate><volume>3</volume><issue>1</issue><spage>40</spage><epage>43</epage><pages>40-43</pages><issn>0974-8490</issn><issn>0976-4836</issn><eissn>0974-8490</eissn><abstract>D. cinerea are the chief source of drug compounds that are active against various ailments such as jaundice, inflammations rheumatism, fever, asthma, body ache, chest problems, toothache, ulcers, wounds, eye diseases and have an aphrodisiac property. In present study, It was aimed to test the hepatoprotective activity of the plant.
The methanolic extract of Dichrostachys cinerea (Mimoseae) leaves was subjected to evaluation of acute toxicity and hepatoprotective property, using albino mice and rats. The parameters for estimation of liver function, based on serum markers such as total bilirubin, total protein, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase with histopathological profile of the liver tissue, were studied consequently.
The methanolic extract did not show any mortality up to a dose of 3500 mg/kg body weight. The methanolic extract showed significant hepatoprotectivity. The histopathological profile of the drug-treated liver tissue demonstrated similar morphology as that of controls.
Methanolic extract of Dichrostachys cinerea was found to have significant hepatoprotective activity.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>21731394</pmid><doi>10.4103/0974-8490.79114</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0974-8490 |
| ispartof | Pharmacognosy research, 2011-01, Vol.3 (1), p.40-43 |
| issn | 0974-8490 0976-4836 0974-8490 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3119270 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Albinism Animals Beans Chemical properties Cytochrome Drug dosages Endoplasmic reticulum Enzymes Free radicals Health aspects Legumes Lipids Liver diseases Materia medica, Vegetable Metabolism Methanol Mimosaceae Original Pharmacy Plant extracts Prevention Proteins Risk factors Rodents Statistical analysis Studies Toxicity Variance analysis |
| title | Evaluation of acute toxicity and hepatoprotective activity of the methanolic extract of Dichrostachys cinerea (Wight and Arn.) leaves |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T07%3A55%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20acute%20toxicity%20and%20hepatoprotective%20activity%20of%20the%20methanolic%20extract%20of%20Dichrostachys%20cinerea%20(Wight%20and%20Arn.)%20leaves&rft.jtitle=Pharmacognosy%20research&rft.au=Babu,%20P%20Suresh&rft.date=2011-01&rft.volume=3&rft.issue=1&rft.spage=40&rft.epage=43&rft.pages=40-43&rft.issn=0974-8490&rft.eissn=0974-8490&rft_id=info:doi/10.4103/0974-8490.79114&rft_dat=%3Cgale_pubme%3EA254151455%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1867558580&rft_id=info:pmid/21731394&rft_galeid=A254151455&rfr_iscdi=true |