Analysis of PCB congeners related to cognitive functioning in adolescents

To investigate the characteristics of PCBs that are linked to cognitive functioning, those congeners that were concurrently found in 271 Mohawk adolescents were grouped according to structure (dioxin-like or non-dioxin-like) and persistence (persistent or low-persistent). After the effects of the co...

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Veröffentlicht in:Neurotoxicology (Park Forest South) 2009-07, Vol.30 (4), p.686-696
Hauptverfasser: Newman, Joan, Gallo, Mia V., Schell, Lawrence M., DeCaprio, Anthony P., Denham, Melinda, Deane, Glenn D.
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container_end_page 696
container_issue 4
container_start_page 686
container_title Neurotoxicology (Park Forest South)
container_volume 30
creator Newman, Joan
Gallo, Mia V.
Schell, Lawrence M.
DeCaprio, Anthony P.
Denham, Melinda
Deane, Glenn D.
description To investigate the characteristics of PCBs that are linked to cognitive functioning, those congeners that were concurrently found in 271 Mohawk adolescents were grouped according to structure (dioxin-like or non-dioxin-like) and persistence (persistent or low-persistent). After the effects of the congener groups were orthogonalized, regression analyses (controlling for a number of variables found to be related to the cognitive outcomes) examined the relationship of each congener group to scores on three cognitive tests (the non-verbal Ravens Progressive Matrices, the Test of Memory and Learning, and the Woodcock Johnson-Revised). Five subtests from these cognitive tests were found to be associated with one or more PCB congener groups, most often at a moderate level. Two measures of long-term memory (Delayed Recall and Long Term Retrieval) were associated with all four congener groups. Nevertheless, examination of the role of individual congeners in the significantly related congener groups revealed that almost all congeners associated with cognitive outcomes were non-dioxin-like and ortho-substituted. A notable exception was the Ravens test where scores were associated only with dioxin-like congeners. This finding adds to the limited evidence of neurotoxic effects of dioxin-like congeners. Auditory Processing was related only to the persistent congener group. The association of the non-persistent congener group with three cognitive test scores (Delayed Recall, Long Term Retrieval and Comprehension-Knowledge) suggests that the Mohawk adolescents have experienced continuing or recent environmental exposure to PCBs that is sufficient to result in detectable cognitive decrements. Comparison of our findings with those of other human studies was limited by the relative lack of specificity of both PCB measures and cognitive outcome measures in much previous work.
doi_str_mv 10.1016/j.neuro.2009.05.006
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subjects Adolescent
Adolescent Development - drug effects
Adolescents
Biological and medical sciences
Child
Cognition
Cognition - drug effects
Congeners
Environmental Exposure
Environmental Pollutants - adverse effects
Female
Humans
Indians, North American
Male
Medical sciences
Memory
Mohawk
Mother-Child Relations
Neuropsychological Tests
Polychlorinated biphenyls
Polychlorinated Biphenyls - adverse effects
Regression Analysis
Retrospective Studies
Toxicology
title Analysis of PCB congeners related to cognitive functioning in adolescents
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