Effect of cigarette smoke and dexamethasone on Hsp72 system of alveolar epithelial cells

Smoking is the leading risk factor of chronic obstructive pulmonary disease (COPD) and lung cancer.Corticosteroids are abundantly used in these patients; however, the interaction of smoking and steroid treatment is not fully understood. Heat shock proteins (Hsps) play a central role in the maintenan...

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Veröffentlicht in:	Cell stress & chaperones 2011-07, Vol.16 (4), p.369-378
Hauptverfasser:	Gál, Krisztina, Cseh, Áron, Szalay, Balázs, Rusai, Krisztina, Vannay, Ádám, Lukácsovits, József, Heemann, Uwe, Szabó, Attila J., Losonczy, György, Tamási, Lilla, Müller, Veronika
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Biochemistry Biomedical and Life Sciences Biomedicine Cancer Research Cell Biology Cell Line Cell lines Chronic obstructive pulmonary disease Cigarette smoking Cigarettes Cytoprotection Dexamethasone - pharmacology Dose-Response Relationship, Drug Epithelial cells Gene Expression Gene Silencing HSP72 Heat-Shock Proteins - genetics HSP72 Heat-Shock Proteins - metabolism Humans Immunology Lungs Necrosis - metabolism Neurosciences Nicotiana - adverse effects Original Paper Pulmonary alveoli Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Respiratory Mucosa - drug effects Respiratory Mucosa - metabolism RNA, Messenger - metabolism RNA, Small Interfering - genetics Small interfering RNA Smoke - adverse effects Smoking - adverse effects Steroids
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