Ectopic expression of wild-type FGFR3 cooperates with MYC to accelerate development of B-cell lineage neoplasms

The t(4;14) translocation in multiple myeloma (MM) simultaneously dysregulates two apparent oncogenes: fibroblast growth factor receptor 3 ( FGFR3 ) controlled by the 3′ immunoglobulin heavy chain enhancer on der(14) and MMSET controlled by the intronic Eμ enhancer on der(4). Although all MM tumors...

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Veröffentlicht in:	Leukemia 2010-06, Vol.24 (6), p.1171-1178
Hauptverfasser:	Zingone, A, Cultraro, C M, Shin, D-M, Bean, C M, Morse, H C, Janz, S, Kuehl, W M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/395 692/420/2489/1381/1853 692/699/67/1990/291/1621/1915 692/699/67/1990/804 Animals B-cell lymphoma Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Blotting, Southern Blotting, Western Cancer Research Cell lineage Cloning Critical Care Medicine Development and progression Ectopic expression Female Fibroblast growth factor receptor 3 Fibroblast growth factor receptors Fibroblast growth factors Gene Expression Profiling Genes, Immunoglobulin Genetic aspects Growth factors Hematologic and hematopoietic diseases Hematology Humans Hyperplasia Immunodeficiencies. Immunoglobulinopathies Immunoenzyme Techniques Immunoglobulinopathies Immunoglobulins Immunopathology Immunophenotyping Immunoprecipitation Intensive Internal Medicine Kinases Latency Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Ligands Lymphocytes B Lymphocytic leukemia Lymphoid cells Lymphoma Lymphoma, B-Cell - etiology Lymphoma, B-Cell - pathology Male Medical prognosis Medical research Medical sciences Medicine Medicine & Public Health Mice Mice, Transgenic Multiple myeloma Multiple Myeloma - etiology Multiple Myeloma - pathology Mutation Myc protein Neoplasms Oligonucleotide Array Sequence Analysis Oncology original-article Pathogenesis Physiological aspects Proto-Oncogene Proteins c-myc - physiology Receptor, Fibroblast Growth Factor, Type 3 - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Translocation Translocation (Genetics) Tumorigenesis Tumors
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