Antihypertriglyceridemia and Anti-Inflammatory Activities of Monascus-Fermented Dioscorea in Streptozotocin-Induced Diabetic Rats
The rice fermented by Monascus, called red mold rice (RMR), and has a long tradition in East Asia as a dietary staple. Monascus-fermented dioscorea called red mold dioscorea (RMD) contains various metabolites to perform the ability of reducing oxidative stress and anti-inflammatory response. We used...
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| Veröffentlicht in: | Experimental diabetes research 2011-01, Vol.2011 (2011), p.1-11 |
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| creator | Shi, Yeu-Ching Liao, Jiunn-Wang Pan, Tzu-Ming |
| description | The rice fermented by Monascus, called red mold rice (RMR), and has a long tradition in East Asia as a dietary staple. Monascus-fermented dioscorea called red mold dioscorea (RMD) contains various metabolites to perform the ability of reducing oxidative stress and anti-inflammatory response. We used Wistar rats and induced diabetes by injecting streptozotocin (STZ, 65 mg/kg i.p.). RMD was administered daily starting six weeks after disease onset. Throughout the experimental period, significantly (P |
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Monascus-fermented dioscorea called red mold dioscorea (RMD) contains various metabolites to perform the ability of reducing oxidative stress and anti-inflammatory response. We used Wistar rats and induced diabetes by injecting streptozotocin (STZ, 65 mg/kg i.p.). RMD was administered daily starting six weeks after disease onset. Throughout the experimental period, significantly (P<.05) lowered plasma glucose, triglyceride, cholesterol, free fatty acid and low density lipoprotein levels were observed in the RMD-treated groups. The RMD-treated diabetic rats showed higher activities of glutathione disulfide reductase, glutathione reductase, catalase and superoxide dismutase (P<.05) in the pancreas compared with the diabetic control rats. RMD also inhibited diabetes-induced elevation in the levels of interleukin (IL)-1β, IL-6, interferon-γ and tumor necrosis factor-α. Pancreatic β-cells damaged by STZ in the RMD supplemented groups were ameliorated. The results of this study clearly demonstrated that RMD possesses several treatment-oriented properties, including the control of hyperglycemia, antioxidant effects, pancreatic β-cell protection and anti-inflammatory effects. Considering these observations, it appears that RMD may be a useful supplement to delay the development of diabetes and its complications.</description><identifier>ISSN: 1687-5214</identifier><identifier>EISSN: 1687-5303</identifier><identifier>DOI: 10.1155/2011/710635</identifier><identifier>PMID: 21716679</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Animals ; Anti-Inflammatory Agents - pharmacology ; Blood Glucose - drug effects ; Care and treatment ; Catalase - metabolism ; Cholesterol - blood ; Complications and side effects ; Diabetes ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Experimental - pathology ; Diagnosis ; Dioscorea - metabolism ; Fatty Acids, Nonesterified - blood ; Fermentation ; Glutathione Reductase - metabolism ; Health aspects ; Hypertriglyceridemia - drug therapy ; Insulin - blood ; Interferon-gamma - blood ; Interleukin-1beta - blood ; Interleukin-6 - blood ; Lipoproteins, LDL - blood ; Male ; Monascus - metabolism ; Pancreas - drug effects ; Pancreas - enzymology ; Rats ; Streptozocin ; Superoxide Dismutase - metabolism ; Triglycerides - blood ; Tumor Necrosis Factor-alpha - blood ; Yams</subject><ispartof>Experimental diabetes research, 2011-01, Vol.2011 (2011), p.1-11</ispartof><rights>Copyright © 2011 Yeu-Ching Shi et al.</rights><rights>COPYRIGHT 2011 John Wiley & Sons, Inc.</rights><rights>Copyright © 2011 Yeu-Ching Shi et al. 2011</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-73abea0d161f8f2a972d50cad0f259ce5111776f53971ad5d45c558051659d3a3</citedby><cites>FETCH-LOGICAL-c467t-73abea0d161f8f2a972d50cad0f259ce5111776f53971ad5d45c558051659d3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118455/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118455/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21716679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cameron, N.</contributor><creatorcontrib>Shi, Yeu-Ching</creatorcontrib><creatorcontrib>Liao, Jiunn-Wang</creatorcontrib><creatorcontrib>Pan, Tzu-Ming</creatorcontrib><title>Antihypertriglyceridemia and Anti-Inflammatory Activities of Monascus-Fermented Dioscorea in Streptozotocin-Induced Diabetic Rats</title><title>Experimental diabetes research</title><addtitle>Exp Diabetes Res</addtitle><description>The rice fermented by Monascus, called red mold rice (RMR), and has a long tradition in East Asia as a dietary staple. Monascus-fermented dioscorea called red mold dioscorea (RMD) contains various metabolites to perform the ability of reducing oxidative stress and anti-inflammatory response. We used Wistar rats and induced diabetes by injecting streptozotocin (STZ, 65 mg/kg i.p.). RMD was administered daily starting six weeks after disease onset. Throughout the experimental period, significantly (P<.05) lowered plasma glucose, triglyceride, cholesterol, free fatty acid and low density lipoprotein levels were observed in the RMD-treated groups. The RMD-treated diabetic rats showed higher activities of glutathione disulfide reductase, glutathione reductase, catalase and superoxide dismutase (P<.05) in the pancreas compared with the diabetic control rats. RMD also inhibited diabetes-induced elevation in the levels of interleukin (IL)-1β, IL-6, interferon-γ and tumor necrosis factor-α. Pancreatic β-cells damaged by STZ in the RMD supplemented groups were ameliorated. The results of this study clearly demonstrated that RMD possesses several treatment-oriented properties, including the control of hyperglycemia, antioxidant effects, pancreatic β-cell protection and anti-inflammatory effects. Considering these observations, it appears that RMD may be a useful supplement to delay the development of diabetes and its complications.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Blood Glucose - drug effects</subject><subject>Care and treatment</subject><subject>Catalase - metabolism</subject><subject>Cholesterol - blood</subject><subject>Complications and side effects</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Experimental - pathology</subject><subject>Diagnosis</subject><subject>Dioscorea - metabolism</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Fermentation</subject><subject>Glutathione Reductase - metabolism</subject><subject>Health aspects</subject><subject>Hypertriglyceridemia - drug therapy</subject><subject>Insulin - blood</subject><subject>Interferon-gamma - blood</subject><subject>Interleukin-1beta - blood</subject><subject>Interleukin-6 - blood</subject><subject>Lipoproteins, LDL - blood</subject><subject>Male</subject><subject>Monascus - metabolism</subject><subject>Pancreas - drug effects</subject><subject>Pancreas - enzymology</subject><subject>Rats</subject><subject>Streptozocin</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Triglycerides - blood</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Yams</subject><issn>1687-5214</issn><issn>1687-5303</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqFkk1rFTEUhgdRbK2uXCsDLgRl2pyZSTKzES7VaqEi-LEOaXJyb2QmuU0ylevOf27GaS8WBMkiIec5L-fjLYqnQI4BKD2pCcAJB8Iaeq84BNbxijakuX_7rqE9KB7F-J2QllHaPSwOauDAGO8Pi18rl-xmt8WQgl0PO4XBahytLKXT5Ryszp0Z5DjK5MOuXKlkr22yGEtvyo_eyaimWJ1hGNEl1OVb66PyAWVpXfklBdwm_9Mnr6zLSnpSfxh5icmq8rNM8XHxwMgh4pOb-6j4dvbu6-mH6uLT-_PT1UWlWsZTxZucI4kGBqYztex5rSlRUhNT014hBQDOmaFNz0FqqluqcrOEAqO9bmRzVLxZdLfT5Yha5XKDHMQ22FGGnfDSirsRZzdi7a9FA9C1lGaBlzcCwV9NGJMYbVQ4DNKhn6LoeNt2tG26TL5YyLUcUFhnfBZUMy1WNctLA9bXmTr-B5XPPH_lHRqb_-8kvF4SVPAxBjT74oGI2QpitoJYrJDp53_3u2dvd5-BVwuwsU7LH_Y_as8WGDOCRu7htq_n4fwGDkTG4w</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Shi, Yeu-Ching</creator><creator>Liao, Jiunn-Wang</creator><creator>Pan, Tzu-Ming</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110101</creationdate><title>Antihypertriglyceridemia and Anti-Inflammatory Activities of Monascus-Fermented Dioscorea in Streptozotocin-Induced Diabetic Rats</title><author>Shi, Yeu-Ching ; Liao, Jiunn-Wang ; Pan, Tzu-Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-73abea0d161f8f2a972d50cad0f259ce5111776f53971ad5d45c558051659d3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Blood Glucose - drug effects</topic><topic>Care and treatment</topic><topic>Catalase - metabolism</topic><topic>Cholesterol - blood</topic><topic>Complications and side effects</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes Mellitus, Experimental - pathology</topic><topic>Diagnosis</topic><topic>Dioscorea - metabolism</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Fermentation</topic><topic>Glutathione Reductase - metabolism</topic><topic>Health aspects</topic><topic>Hypertriglyceridemia - drug therapy</topic><topic>Insulin - blood</topic><topic>Interferon-gamma - blood</topic><topic>Interleukin-1beta - blood</topic><topic>Interleukin-6 - blood</topic><topic>Lipoproteins, LDL - blood</topic><topic>Male</topic><topic>Monascus - metabolism</topic><topic>Pancreas - drug effects</topic><topic>Pancreas - enzymology</topic><topic>Rats</topic><topic>Streptozocin</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Triglycerides - blood</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Yams</topic><toplevel>online_resources</toplevel><creatorcontrib>Shi, Yeu-Ching</creatorcontrib><creatorcontrib>Liao, Jiunn-Wang</creatorcontrib><creatorcontrib>Pan, Tzu-Ming</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental diabetes research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Yeu-Ching</au><au>Liao, Jiunn-Wang</au><au>Pan, Tzu-Ming</au><au>Cameron, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antihypertriglyceridemia and Anti-Inflammatory Activities of Monascus-Fermented Dioscorea in Streptozotocin-Induced Diabetic Rats</atitle><jtitle>Experimental diabetes research</jtitle><addtitle>Exp Diabetes Res</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>2011</volume><issue>2011</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>1687-5214</issn><eissn>1687-5303</eissn><abstract>The rice fermented by Monascus, called red mold rice (RMR), and has a long tradition in East Asia as a dietary staple. Monascus-fermented dioscorea called red mold dioscorea (RMD) contains various metabolites to perform the ability of reducing oxidative stress and anti-inflammatory response. We used Wistar rats and induced diabetes by injecting streptozotocin (STZ, 65 mg/kg i.p.). RMD was administered daily starting six weeks after disease onset. Throughout the experimental period, significantly (P<.05) lowered plasma glucose, triglyceride, cholesterol, free fatty acid and low density lipoprotein levels were observed in the RMD-treated groups. The RMD-treated diabetic rats showed higher activities of glutathione disulfide reductase, glutathione reductase, catalase and superoxide dismutase (P<.05) in the pancreas compared with the diabetic control rats. RMD also inhibited diabetes-induced elevation in the levels of interleukin (IL)-1β, IL-6, interferon-γ and tumor necrosis factor-α. Pancreatic β-cells damaged by STZ in the RMD supplemented groups were ameliorated. The results of this study clearly demonstrated that RMD possesses several treatment-oriented properties, including the control of hyperglycemia, antioxidant effects, pancreatic β-cell protection and anti-inflammatory effects. Considering these observations, it appears that RMD may be a useful supplement to delay the development of diabetes and its complications.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>21716679</pmid><doi>10.1155/2011/710635</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents - pharmacology Blood Glucose - drug effects Care and treatment Catalase - metabolism Cholesterol - blood Complications and side effects Diabetes Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diagnosis Dioscorea - metabolism Fatty Acids, Nonesterified - blood Fermentation Glutathione Reductase - metabolism Health aspects Hypertriglyceridemia - drug therapy Insulin - blood Interferon-gamma - blood Interleukin-1beta - blood Interleukin-6 - blood Lipoproteins, LDL - blood Male Monascus - metabolism Pancreas - drug effects Pancreas - enzymology Rats Streptozocin Superoxide Dismutase - metabolism Triglycerides - blood Tumor Necrosis Factor-alpha - blood Yams |
| title | Antihypertriglyceridemia and Anti-Inflammatory Activities of Monascus-Fermented Dioscorea in Streptozotocin-Induced Diabetic Rats |
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