Gastric motor disturbances in patients with idiopathic rapid gastric emptying
Background The mechanisms of ‘idiopathic’ rapid gastric emptying, which are associated with functional dyspepsia and functional diarrhea, are not understood. Our hypotheses were that increased gastric motility and reduced postprandial gastric accommodation contribute to rapid gastric emptying. Meth...
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| Veröffentlicht in: | Neurogastroenterology and motility 2011-07, Vol.23 (7), p.617-e252 |
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| creator | Bharucha, A. E. Manduca, A. Lake, D. S. Fidler, J. Edwards, P. Grimm, R. C. Zinsmeister, A. R. Riederer, S. J. |
| description | Background The mechanisms of ‘idiopathic’ rapid gastric emptying, which are associated with functional dyspepsia and functional diarrhea, are not understood. Our hypotheses were that increased gastric motility and reduced postprandial gastric accommodation contribute to rapid gastric emptying.
Methods Fasting and postprandial (300 kcal nutrient meal) gastric volumes were measured by magnetic resonance imaging (MRI) in 20 healthy people and 17 with functional dyspepsia; seven had normal and 10 had rapid gastric emptying. In 17 healthy people and patients, contractility was analyzed by spectral analysis of a time‐series of gastric cross‐sectional areas. Logistic regression models analyzed whether contractile parameters, fasting volume, and postprandial volume change could discriminate between health and patients with normal or rapid gastric emptying.
Key Results While upper gastrointestinal symptoms were comparable, patients with rapid emptying had a higher (P = 0.002) body mass index than normal gastric emptying. MRI visualized propagating contractions at ∼3 cpm in healthy people and patients. Compared with controls (0.32 ± 0.04, Mean ± SEM), the amplitude of gastric contractions in the entire stomach was higher (OR 4.1, 95% CI 1.2–14.0) in patients with rapid (0.48 ± 0.06), but not normal gastric emptying (0.20 ± 0.06). Similar differences were observed in the distal stomach. However, the propagation velocity, fasting gastric volume, and the postprandial volume change were not significantly different between patients and controls.
Conclusions & Inferences MRI provides a non‐invasive and refined assessment of gastric volumes and contractility in humans. Increased gastric contractility may contribute to rapid gastric emptying in functional dyspepsia. |
| doi_str_mv | 10.1111/j.1365-2982.2011.01710.x |
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Methods Fasting and postprandial (300 kcal nutrient meal) gastric volumes were measured by magnetic resonance imaging (MRI) in 20 healthy people and 17 with functional dyspepsia; seven had normal and 10 had rapid gastric emptying. In 17 healthy people and patients, contractility was analyzed by spectral analysis of a time‐series of gastric cross‐sectional areas. Logistic regression models analyzed whether contractile parameters, fasting volume, and postprandial volume change could discriminate between health and patients with normal or rapid gastric emptying.
Key Results While upper gastrointestinal symptoms were comparable, patients with rapid emptying had a higher (P = 0.002) body mass index than normal gastric emptying. MRI visualized propagating contractions at ∼3 cpm in healthy people and patients. Compared with controls (0.32 ± 0.04, Mean ± SEM), the amplitude of gastric contractions in the entire stomach was higher (OR 4.1, 95% CI 1.2–14.0) in patients with rapid (0.48 ± 0.06), but not normal gastric emptying (0.20 ± 0.06). Similar differences were observed in the distal stomach. However, the propagation velocity, fasting gastric volume, and the postprandial volume change were not significantly different between patients and controls.
Conclusions & Inferences MRI provides a non‐invasive and refined assessment of gastric volumes and contractility in humans. Increased gastric contractility may contribute to rapid gastric emptying in functional dyspepsia.</description><identifier>ISSN: 1350-1925</identifier><identifier>EISSN: 1365-2982</identifier><identifier>DOI: 10.1111/j.1365-2982.2011.01710.x</identifier><identifier>PMID: 21470342</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Body mass index ; Case-Control Studies ; Contractility ; Diarrhea ; dumping ; dyspepsia ; Dyspepsia - pathology ; Dyspepsia - physiopathology ; Fasting ; Female ; functional dyspepsia ; Gastric emptying ; Gastric Emptying - physiology ; Gastric motility ; Gastrointestinal Motility - physiology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Muscle Contraction - physiology ; Nutrients ; Organ Size ; Postprandial Period ; rapid gastric emptying ; Regression Analysis ; Stomach ; Stomach - pathology ; Stomach - physiopathology ; Velocity</subject><ispartof>Neurogastroenterology and motility, 2011-07, Vol.23 (7), p.617-e252</ispartof><rights>2011 Blackwell Publishing Ltd</rights><rights>2011 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4560-4cb13f78c1d55056aeb644521cb6247a54055b27c4babd2eec77761e9ad7ef643</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2982.2011.01710.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2982.2011.01710.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21470342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bharucha, A. E.</creatorcontrib><creatorcontrib>Manduca, A.</creatorcontrib><creatorcontrib>Lake, D. S.</creatorcontrib><creatorcontrib>Fidler, J.</creatorcontrib><creatorcontrib>Edwards, P.</creatorcontrib><creatorcontrib>Grimm, R. C.</creatorcontrib><creatorcontrib>Zinsmeister, A. R.</creatorcontrib><creatorcontrib>Riederer, S. J.</creatorcontrib><title>Gastric motor disturbances in patients with idiopathic rapid gastric emptying</title><title>Neurogastroenterology and motility</title><addtitle>Neurogastroenterol Motil</addtitle><description>Background The mechanisms of ‘idiopathic’ rapid gastric emptying, which are associated with functional dyspepsia and functional diarrhea, are not understood. Our hypotheses were that increased gastric motility and reduced postprandial gastric accommodation contribute to rapid gastric emptying.
Methods Fasting and postprandial (300 kcal nutrient meal) gastric volumes were measured by magnetic resonance imaging (MRI) in 20 healthy people and 17 with functional dyspepsia; seven had normal and 10 had rapid gastric emptying. In 17 healthy people and patients, contractility was analyzed by spectral analysis of a time‐series of gastric cross‐sectional areas. Logistic regression models analyzed whether contractile parameters, fasting volume, and postprandial volume change could discriminate between health and patients with normal or rapid gastric emptying.
Key Results While upper gastrointestinal symptoms were comparable, patients with rapid emptying had a higher (P = 0.002) body mass index than normal gastric emptying. MRI visualized propagating contractions at ∼3 cpm in healthy people and patients. Compared with controls (0.32 ± 0.04, Mean ± SEM), the amplitude of gastric contractions in the entire stomach was higher (OR 4.1, 95% CI 1.2–14.0) in patients with rapid (0.48 ± 0.06), but not normal gastric emptying (0.20 ± 0.06). Similar differences were observed in the distal stomach. However, the propagation velocity, fasting gastric volume, and the postprandial volume change were not significantly different between patients and controls.
Conclusions & Inferences MRI provides a non‐invasive and refined assessment of gastric volumes and contractility in humans. Increased gastric contractility may contribute to rapid gastric emptying in functional dyspepsia.</description><subject>Adult</subject><subject>Body mass index</subject><subject>Case-Control Studies</subject><subject>Contractility</subject><subject>Diarrhea</subject><subject>dumping</subject><subject>dyspepsia</subject><subject>Dyspepsia - pathology</subject><subject>Dyspepsia - physiopathology</subject><subject>Fasting</subject><subject>Female</subject><subject>functional dyspepsia</subject><subject>Gastric emptying</subject><subject>Gastric Emptying - physiology</subject><subject>Gastric motility</subject><subject>Gastrointestinal Motility - physiology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle Contraction - physiology</subject><subject>Nutrients</subject><subject>Organ Size</subject><subject>Postprandial Period</subject><subject>rapid gastric emptying</subject><subject>Regression Analysis</subject><subject>Stomach</subject><subject>Stomach - pathology</subject><subject>Stomach - physiopathology</subject><subject>Velocity</subject><issn>1350-1925</issn><issn>1365-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtPAjEUhRujEUT_gpmdqxl7O30wC00MUTQB2ei66XQKlMzL6SDw7-0IEt3ZTW_uOT056YdQADgCf25XEcSchSQZkohggAiD8Nr2BPWPwmk3MxxCQlgPXTi3whhzQvk56hGgAseU9NF0rFzbWB0UVVs1QWZdu25SVWrjAlsGtWqtKVsXbGy7DGxmK79ZenujapsFi8NjU9TtzpaLS3Q2V7kzV4d7gN6fHt9Gz-FkNn4ZPUxCTRnHIdUpxHMx1JAxhhlXJuWUMgI69QWFYhQzlhKhaarSjBijhRAcTKIyYeacxgN0v8-t12lhMu0rNiqXdWML1exkpaz8q5R2KRfVp4wBRELAB9wcAprqY21cKwvrtMlzVZpq7eRwGGMS-7L_cALlCafEO69_lzq2-flsb7jbGzY2N7ujDlh2UOVKduxkx052UOU3VLmVr9NZN8VfzEeWtw</recordid><startdate>201107</startdate><enddate>201107</enddate><creator>Bharucha, A. E.</creator><creator>Manduca, A.</creator><creator>Lake, D. S.</creator><creator>Fidler, J.</creator><creator>Edwards, P.</creator><creator>Grimm, R. C.</creator><creator>Zinsmeister, A. R.</creator><creator>Riederer, S. J.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>201107</creationdate><title>Gastric motor disturbances in patients with idiopathic rapid gastric emptying</title><author>Bharucha, A. E. ; Manduca, A. ; Lake, D. S. ; Fidler, J. ; Edwards, P. ; Grimm, R. C. ; Zinsmeister, A. R. ; Riederer, S. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4560-4cb13f78c1d55056aeb644521cb6247a54055b27c4babd2eec77761e9ad7ef643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Body mass index</topic><topic>Case-Control Studies</topic><topic>Contractility</topic><topic>Diarrhea</topic><topic>dumping</topic><topic>dyspepsia</topic><topic>Dyspepsia - pathology</topic><topic>Dyspepsia - physiopathology</topic><topic>Fasting</topic><topic>Female</topic><topic>functional dyspepsia</topic><topic>Gastric emptying</topic><topic>Gastric Emptying - physiology</topic><topic>Gastric motility</topic><topic>Gastrointestinal Motility - physiology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle Contraction - physiology</topic><topic>Nutrients</topic><topic>Organ Size</topic><topic>Postprandial Period</topic><topic>rapid gastric emptying</topic><topic>Regression Analysis</topic><topic>Stomach</topic><topic>Stomach - pathology</topic><topic>Stomach - physiopathology</topic><topic>Velocity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bharucha, A. E.</creatorcontrib><creatorcontrib>Manduca, A.</creatorcontrib><creatorcontrib>Lake, D. S.</creatorcontrib><creatorcontrib>Fidler, J.</creatorcontrib><creatorcontrib>Edwards, P.</creatorcontrib><creatorcontrib>Grimm, R. C.</creatorcontrib><creatorcontrib>Zinsmeister, A. R.</creatorcontrib><creatorcontrib>Riederer, S. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurogastroenterology and motility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bharucha, A. E.</au><au>Manduca, A.</au><au>Lake, D. S.</au><au>Fidler, J.</au><au>Edwards, P.</au><au>Grimm, R. C.</au><au>Zinsmeister, A. R.</au><au>Riederer, S. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastric motor disturbances in patients with idiopathic rapid gastric emptying</atitle><jtitle>Neurogastroenterology and motility</jtitle><addtitle>Neurogastroenterol Motil</addtitle><date>2011-07</date><risdate>2011</risdate><volume>23</volume><issue>7</issue><spage>617</spage><epage>e252</epage><pages>617-e252</pages><issn>1350-1925</issn><eissn>1365-2982</eissn><abstract>Background The mechanisms of ‘idiopathic’ rapid gastric emptying, which are associated with functional dyspepsia and functional diarrhea, are not understood. Our hypotheses were that increased gastric motility and reduced postprandial gastric accommodation contribute to rapid gastric emptying.
Methods Fasting and postprandial (300 kcal nutrient meal) gastric volumes were measured by magnetic resonance imaging (MRI) in 20 healthy people and 17 with functional dyspepsia; seven had normal and 10 had rapid gastric emptying. In 17 healthy people and patients, contractility was analyzed by spectral analysis of a time‐series of gastric cross‐sectional areas. Logistic regression models analyzed whether contractile parameters, fasting volume, and postprandial volume change could discriminate between health and patients with normal or rapid gastric emptying.
Key Results While upper gastrointestinal symptoms were comparable, patients with rapid emptying had a higher (P = 0.002) body mass index than normal gastric emptying. MRI visualized propagating contractions at ∼3 cpm in healthy people and patients. Compared with controls (0.32 ± 0.04, Mean ± SEM), the amplitude of gastric contractions in the entire stomach was higher (OR 4.1, 95% CI 1.2–14.0) in patients with rapid (0.48 ± 0.06), but not normal gastric emptying (0.20 ± 0.06). Similar differences were observed in the distal stomach. However, the propagation velocity, fasting gastric volume, and the postprandial volume change were not significantly different between patients and controls.
Conclusions & Inferences MRI provides a non‐invasive and refined assessment of gastric volumes and contractility in humans. Increased gastric contractility may contribute to rapid gastric emptying in functional dyspepsia.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21470342</pmid><doi>10.1111/j.1365-2982.2011.01710.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Body mass index Case-Control Studies Contractility Diarrhea dumping dyspepsia Dyspepsia - pathology Dyspepsia - physiopathology Fasting Female functional dyspepsia Gastric emptying Gastric Emptying - physiology Gastric motility Gastrointestinal Motility - physiology Humans Magnetic Resonance Imaging Male Middle Aged Muscle Contraction - physiology Nutrients Organ Size Postprandial Period rapid gastric emptying Regression Analysis Stomach Stomach - pathology Stomach - physiopathology Velocity |
| title | Gastric motor disturbances in patients with idiopathic rapid gastric emptying |
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