USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1

Tumour suppressor p53 levels in the cell are tightly regulated by controlled degradation through ubiquitin ligases including Mdm2, COP1, Pirh2, and ARF‐BP1. The ubiquitination process is reversible via deubiquitinating enzymes, such as ubiquitin‐specific peptidases (USPs). In this study, we identifi...

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Veröffentlicht in:	The EMBO journal 2011-06, Vol.30 (11), p.2177-2189
Hauptverfasser:	Zhang, Xinna, Berger, Franklin G, Yang, Jianhua, Lu, Xiongbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis ARF-BP1 Cells, Cultured Deoxyribonucleic acid deubiquitination DNA DNA damage EMBO13 EMBO31 Fibroblasts - physiology Gene Knockout Techniques Genomes Ionizing radiation Mice Mice, Knockout Molecular biology Oncogene Proteins - genetics Oncogene Proteins - metabolism p53 Peptides Proteins Proto-Oncogene Proteins Radiation, Ionizing Radiography Spleen - pathology Spleen - radiation effects Thymus Gland - diagnostic imaging Thymus Gland - pathology Tumor Suppressor Protein p53 - antagonists & inhibitors Tumor Suppressor Proteins Tumors Ubiquitin Thiolesterase Ubiquitin-Protein Ligases - metabolism Ubiquitin-Specific Proteases USP4
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