Reversion of gene expression alterations in hearts of mice with chronic chagasic cardiomyopathy after transplantation of bone marrow cells
Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries, being associated with intense inflammatory response and fibrosis. We have previously shown that bone marrow mononuclear cell (BMC) transplantation improves inflammation, fibrosis, and ventricular diamete...
Gespeichert in:
| Veröffentlicht in: | Cell cycle (Georgetown, Tex.) Tex.), 2011-05, Vol.10 (9), p.1448-1455 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1455 |
|---|---|
| container_issue | 9 |
| container_start_page | 1448 |
| container_title | Cell cycle (Georgetown, Tex.) |
| container_volume | 10 |
| creator | Soares, Milena B.P. Lima, Ricardo S. Souza, Bruno S.F. Vasconcelos, Juliana F. Rocha, Leonardo L. dos Santos, Ricardo Ribeiro Iacobas, Sanda Goldenberg, Regina C. Lisanti, Michael P. Iacobas, Dumitru A. Tanowitz, Herbert B. Spray, David C. Campos de Carvalho, Antonio C. |
| description | Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries, being associated with intense inflammatory response and fibrosis. We have previously shown that bone marrow mononuclear cell (BMC) transplantation improves inflammation, fibrosis, and ventricular diameter in hearts of mice with chronic Chagas disease. Here we investigated the transcriptomic recovery induced by BMC therapy by comparing the heart transcriptomes of control, chagasic, and BMC transplanted mice. Out of the 9390 unique genes quantified in all samples, 1702 had their expression altered in chronic chagasic hearts compared to those of normal mice. Major categories of significantly upregulated genes were related to inflammation, fibrosis and immune responses, while genes involved in mitochondrion function were downregulated. When BMC-treated chagasic hearts were compared to infected mice, 96% of the alterations detected in infected hearts were restored to normal levels, although an additional 109 genes were altered by treatment. Transcriptomic recovery, a new measure that considers both resotrative and side effects of treatment, was remarkably high (84%). Immunofluorescence and morphometric analyses confirmed the effects of BMC therapy in the pattern of inflammatory-immune response and expression of adhesion molecules. In conclusion, by using large-scale gene profiling for unbiased assessment of therapeutic efficacy we demonstrate immunomodulatory effects of BMC therapy in chronic chagasic cardiomyopathy and identify potentially relevant factors involved in the pathogenesis of the disease that may provide new therapeutic targets. |
| doi_str_mv | 10.4161/cc.10.9.15487 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3117044</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>868030074</sourcerecordid><originalsourceid>FETCH-LOGICAL-c517t-3b8385c0ca8bcc08f02c485d68cd81bad785822285bac36b7e94c3c5eef050413</originalsourceid><addsrcrecordid>eNqFkU2P0zAQhiMEYj_gyBX5xinFTuzEvSChamGRVkLi42xNJpPGKLGDnW7pX-BX47RLBRISJ7-y33lmxm-WvRB8JUUlXiOuklyvhJK6fpRdCqVELjlXjxdd6lwKLi6yqxi_cV7oei2eZheFkFWtZXmZ_fxE9xSi9Y75jm3JEaMfU6B4vIJhpgBzkpFZx3qCMMfFOFoktrdzz7AP3llMJ2whLgJCa_148BPM_YFBlxBsDuDiNICbj7QF0fjUa4QQ_J4hDUN8lj3pYIj0_OG8zr6-u_myuc3vPr7_sHl7l6MS9ZyXjS61Qo6gG0SuO16g1KqtNLZaNNDWWumiKLRqAMuqqWktsURF1HHFpSivszcn7rRrRmqRXJpuMFOwaZqD8WDN3y_O9mbr700pRM2lTIBXD4Dgv-8ozma0cVkBHPldNLrSvOS8Xpz5yYnBxxioO3cR3CzxGcRFrs0xvuR_-edoZ_fvvJKBnwypV0uxsT6iJYd0tiZgCsniQGfm_0o-e0iBbzbHQaa2SyX6VGJd58MIex-G1sxwGHzoUpJoY_qMf27wCxEc0Yw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>868030074</pqid></control><display><type>article</type><title>Reversion of gene expression alterations in hearts of mice with chronic chagasic cardiomyopathy after transplantation of bone marrow cells</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Soares, Milena B.P. ; Lima, Ricardo S. ; Souza, Bruno S.F. ; Vasconcelos, Juliana F. ; Rocha, Leonardo L. ; dos Santos, Ricardo Ribeiro ; Iacobas, Sanda ; Goldenberg, Regina C. ; Lisanti, Michael P. ; Iacobas, Dumitru A. ; Tanowitz, Herbert B. ; Spray, David C. ; Campos de Carvalho, Antonio C.</creator><creatorcontrib>Soares, Milena B.P. ; Lima, Ricardo S. ; Souza, Bruno S.F. ; Vasconcelos, Juliana F. ; Rocha, Leonardo L. ; dos Santos, Ricardo Ribeiro ; Iacobas, Sanda ; Goldenberg, Regina C. ; Lisanti, Michael P. ; Iacobas, Dumitru A. ; Tanowitz, Herbert B. ; Spray, David C. ; Campos de Carvalho, Antonio C.</creatorcontrib><description>Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries, being associated with intense inflammatory response and fibrosis. We have previously shown that bone marrow mononuclear cell (BMC) transplantation improves inflammation, fibrosis, and ventricular diameter in hearts of mice with chronic Chagas disease. Here we investigated the transcriptomic recovery induced by BMC therapy by comparing the heart transcriptomes of control, chagasic, and BMC transplanted mice. Out of the 9390 unique genes quantified in all samples, 1702 had their expression altered in chronic chagasic hearts compared to those of normal mice. Major categories of significantly upregulated genes were related to inflammation, fibrosis and immune responses, while genes involved in mitochondrion function were downregulated. When BMC-treated chagasic hearts were compared to infected mice, 96% of the alterations detected in infected hearts were restored to normal levels, although an additional 109 genes were altered by treatment. Transcriptomic recovery, a new measure that considers both resotrative and side effects of treatment, was remarkably high (84%). Immunofluorescence and morphometric analyses confirmed the effects of BMC therapy in the pattern of inflammatory-immune response and expression of adhesion molecules. In conclusion, by using large-scale gene profiling for unbiased assessment of therapeutic efficacy we demonstrate immunomodulatory effects of BMC therapy in chronic chagasic cardiomyopathy and identify potentially relevant factors involved in the pathogenesis of the disease that may provide new therapeutic targets.</description><identifier>ISSN: 1538-4101</identifier><identifier>EISSN: 1551-4005</identifier><identifier>DOI: 10.4161/cc.10.9.15487</identifier><identifier>PMID: 21467843</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Animals ; Binding ; Biology ; Bioscience ; Bone Marrow Transplantation - immunology ; Bone Marrow Transplantation - pathology ; Calcium ; Cancer ; Cell ; Chagas Cardiomyopathy - genetics ; Chagas Cardiomyopathy - immunology ; Chagas Cardiomyopathy - therapy ; Chronic Disease ; Cycle ; Disease Models, Animal ; Female ; Fibrosis ; Galectin 3 - genetics ; Gene Expression Profiling - methods ; Gene Expression Regulation - immunology ; Landes ; Male ; Mice ; Mice, Inbred C57BL ; Myocardium - immunology ; Myocardium - metabolism ; Myocardium - pathology ; Oligonucleotide Array Sequence Analysis ; Organogenesis ; Proteins ; Syndecan-4 - genetics ; Trypanosoma cruzi - classification ; Trypanosoma cruzi - immunology ; Trypanosoma cruzi - pathogenicity ; von Willebrand Factor - genetics</subject><ispartof>Cell cycle (Georgetown, Tex.), 2011-05, Vol.10 (9), p.1448-1455</ispartof><rights>Copyright © 2011 Landes Bioscience 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-3b8385c0ca8bcc08f02c485d68cd81bad785822285bac36b7e94c3c5eef050413</citedby><cites>FETCH-LOGICAL-c517t-3b8385c0ca8bcc08f02c485d68cd81bad785822285bac36b7e94c3c5eef050413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117044/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117044/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21467843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soares, Milena B.P.</creatorcontrib><creatorcontrib>Lima, Ricardo S.</creatorcontrib><creatorcontrib>Souza, Bruno S.F.</creatorcontrib><creatorcontrib>Vasconcelos, Juliana F.</creatorcontrib><creatorcontrib>Rocha, Leonardo L.</creatorcontrib><creatorcontrib>dos Santos, Ricardo Ribeiro</creatorcontrib><creatorcontrib>Iacobas, Sanda</creatorcontrib><creatorcontrib>Goldenberg, Regina C.</creatorcontrib><creatorcontrib>Lisanti, Michael P.</creatorcontrib><creatorcontrib>Iacobas, Dumitru A.</creatorcontrib><creatorcontrib>Tanowitz, Herbert B.</creatorcontrib><creatorcontrib>Spray, David C.</creatorcontrib><creatorcontrib>Campos de Carvalho, Antonio C.</creatorcontrib><title>Reversion of gene expression alterations in hearts of mice with chronic chagasic cardiomyopathy after transplantation of bone marrow cells</title><title>Cell cycle (Georgetown, Tex.)</title><addtitle>Cell Cycle</addtitle><description>Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries, being associated with intense inflammatory response and fibrosis. We have previously shown that bone marrow mononuclear cell (BMC) transplantation improves inflammation, fibrosis, and ventricular diameter in hearts of mice with chronic Chagas disease. Here we investigated the transcriptomic recovery induced by BMC therapy by comparing the heart transcriptomes of control, chagasic, and BMC transplanted mice. Out of the 9390 unique genes quantified in all samples, 1702 had their expression altered in chronic chagasic hearts compared to those of normal mice. Major categories of significantly upregulated genes were related to inflammation, fibrosis and immune responses, while genes involved in mitochondrion function were downregulated. When BMC-treated chagasic hearts were compared to infected mice, 96% of the alterations detected in infected hearts were restored to normal levels, although an additional 109 genes were altered by treatment. Transcriptomic recovery, a new measure that considers both resotrative and side effects of treatment, was remarkably high (84%). Immunofluorescence and morphometric analyses confirmed the effects of BMC therapy in the pattern of inflammatory-immune response and expression of adhesion molecules. In conclusion, by using large-scale gene profiling for unbiased assessment of therapeutic efficacy we demonstrate immunomodulatory effects of BMC therapy in chronic chagasic cardiomyopathy and identify potentially relevant factors involved in the pathogenesis of the disease that may provide new therapeutic targets.</description><subject>Animals</subject><subject>Binding</subject><subject>Biology</subject><subject>Bioscience</subject><subject>Bone Marrow Transplantation - immunology</subject><subject>Bone Marrow Transplantation - pathology</subject><subject>Calcium</subject><subject>Cancer</subject><subject>Cell</subject><subject>Chagas Cardiomyopathy - genetics</subject><subject>Chagas Cardiomyopathy - immunology</subject><subject>Chagas Cardiomyopathy - therapy</subject><subject>Chronic Disease</subject><subject>Cycle</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Galectin 3 - genetics</subject><subject>Gene Expression Profiling - methods</subject><subject>Gene Expression Regulation - immunology</subject><subject>Landes</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Myocardium - immunology</subject><subject>Myocardium - metabolism</subject><subject>Myocardium - pathology</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Organogenesis</subject><subject>Proteins</subject><subject>Syndecan-4 - genetics</subject><subject>Trypanosoma cruzi - classification</subject><subject>Trypanosoma cruzi - immunology</subject><subject>Trypanosoma cruzi - pathogenicity</subject><subject>von Willebrand Factor - genetics</subject><issn>1538-4101</issn><issn>1551-4005</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P0zAQhiMEYj_gyBX5xinFTuzEvSChamGRVkLi42xNJpPGKLGDnW7pX-BX47RLBRISJ7-y33lmxm-WvRB8JUUlXiOuklyvhJK6fpRdCqVELjlXjxdd6lwKLi6yqxi_cV7oei2eZheFkFWtZXmZ_fxE9xSi9Y75jm3JEaMfU6B4vIJhpgBzkpFZx3qCMMfFOFoktrdzz7AP3llMJ2whLgJCa_148BPM_YFBlxBsDuDiNICbj7QF0fjUa4QQ_J4hDUN8lj3pYIj0_OG8zr6-u_myuc3vPr7_sHl7l6MS9ZyXjS61Qo6gG0SuO16g1KqtNLZaNNDWWumiKLRqAMuqqWktsURF1HHFpSivszcn7rRrRmqRXJpuMFOwaZqD8WDN3y_O9mbr700pRM2lTIBXD4Dgv-8ozma0cVkBHPldNLrSvOS8Xpz5yYnBxxioO3cR3CzxGcRFrs0xvuR_-edoZ_fvvJKBnwypV0uxsT6iJYd0tiZgCsniQGfm_0o-e0iBbzbHQaa2SyX6VGJd58MIex-G1sxwGHzoUpJoY_qMf27wCxEc0Yw</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Soares, Milena B.P.</creator><creator>Lima, Ricardo S.</creator><creator>Souza, Bruno S.F.</creator><creator>Vasconcelos, Juliana F.</creator><creator>Rocha, Leonardo L.</creator><creator>dos Santos, Ricardo Ribeiro</creator><creator>Iacobas, Sanda</creator><creator>Goldenberg, Regina C.</creator><creator>Lisanti, Michael P.</creator><creator>Iacobas, Dumitru A.</creator><creator>Tanowitz, Herbert B.</creator><creator>Spray, David C.</creator><creator>Campos de Carvalho, Antonio C.</creator><general>Taylor & Francis</general><general>Landes Bioscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110501</creationdate><title>Reversion of gene expression alterations in hearts of mice with chronic chagasic cardiomyopathy after transplantation of bone marrow cells</title><author>Soares, Milena B.P. ; Lima, Ricardo S. ; Souza, Bruno S.F. ; Vasconcelos, Juliana F. ; Rocha, Leonardo L. ; dos Santos, Ricardo Ribeiro ; Iacobas, Sanda ; Goldenberg, Regina C. ; Lisanti, Michael P. ; Iacobas, Dumitru A. ; Tanowitz, Herbert B. ; Spray, David C. ; Campos de Carvalho, Antonio C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-3b8385c0ca8bcc08f02c485d68cd81bad785822285bac36b7e94c3c5eef050413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Binding</topic><topic>Biology</topic><topic>Bioscience</topic><topic>Bone Marrow Transplantation - immunology</topic><topic>Bone Marrow Transplantation - pathology</topic><topic>Calcium</topic><topic>Cancer</topic><topic>Cell</topic><topic>Chagas Cardiomyopathy - genetics</topic><topic>Chagas Cardiomyopathy - immunology</topic><topic>Chagas Cardiomyopathy - therapy</topic><topic>Chronic Disease</topic><topic>Cycle</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Galectin 3 - genetics</topic><topic>Gene Expression Profiling - methods</topic><topic>Gene Expression Regulation - immunology</topic><topic>Landes</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Myocardium - immunology</topic><topic>Myocardium - metabolism</topic><topic>Myocardium - pathology</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Organogenesis</topic><topic>Proteins</topic><topic>Syndecan-4 - genetics</topic><topic>Trypanosoma cruzi - classification</topic><topic>Trypanosoma cruzi - immunology</topic><topic>Trypanosoma cruzi - pathogenicity</topic><topic>von Willebrand Factor - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soares, Milena B.P.</creatorcontrib><creatorcontrib>Lima, Ricardo S.</creatorcontrib><creatorcontrib>Souza, Bruno S.F.</creatorcontrib><creatorcontrib>Vasconcelos, Juliana F.</creatorcontrib><creatorcontrib>Rocha, Leonardo L.</creatorcontrib><creatorcontrib>dos Santos, Ricardo Ribeiro</creatorcontrib><creatorcontrib>Iacobas, Sanda</creatorcontrib><creatorcontrib>Goldenberg, Regina C.</creatorcontrib><creatorcontrib>Lisanti, Michael P.</creatorcontrib><creatorcontrib>Iacobas, Dumitru A.</creatorcontrib><creatorcontrib>Tanowitz, Herbert B.</creatorcontrib><creatorcontrib>Spray, David C.</creatorcontrib><creatorcontrib>Campos de Carvalho, Antonio C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell cycle (Georgetown, Tex.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soares, Milena B.P.</au><au>Lima, Ricardo S.</au><au>Souza, Bruno S.F.</au><au>Vasconcelos, Juliana F.</au><au>Rocha, Leonardo L.</au><au>dos Santos, Ricardo Ribeiro</au><au>Iacobas, Sanda</au><au>Goldenberg, Regina C.</au><au>Lisanti, Michael P.</au><au>Iacobas, Dumitru A.</au><au>Tanowitz, Herbert B.</au><au>Spray, David C.</au><au>Campos de Carvalho, Antonio C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reversion of gene expression alterations in hearts of mice with chronic chagasic cardiomyopathy after transplantation of bone marrow cells</atitle><jtitle>Cell cycle (Georgetown, Tex.)</jtitle><addtitle>Cell Cycle</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>10</volume><issue>9</issue><spage>1448</spage><epage>1455</epage><pages>1448-1455</pages><issn>1538-4101</issn><eissn>1551-4005</eissn><abstract>Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries, being associated with intense inflammatory response and fibrosis. We have previously shown that bone marrow mononuclear cell (BMC) transplantation improves inflammation, fibrosis, and ventricular diameter in hearts of mice with chronic Chagas disease. Here we investigated the transcriptomic recovery induced by BMC therapy by comparing the heart transcriptomes of control, chagasic, and BMC transplanted mice. Out of the 9390 unique genes quantified in all samples, 1702 had their expression altered in chronic chagasic hearts compared to those of normal mice. Major categories of significantly upregulated genes were related to inflammation, fibrosis and immune responses, while genes involved in mitochondrion function were downregulated. When BMC-treated chagasic hearts were compared to infected mice, 96% of the alterations detected in infected hearts were restored to normal levels, although an additional 109 genes were altered by treatment. Transcriptomic recovery, a new measure that considers both resotrative and side effects of treatment, was remarkably high (84%). Immunofluorescence and morphometric analyses confirmed the effects of BMC therapy in the pattern of inflammatory-immune response and expression of adhesion molecules. In conclusion, by using large-scale gene profiling for unbiased assessment of therapeutic efficacy we demonstrate immunomodulatory effects of BMC therapy in chronic chagasic cardiomyopathy and identify potentially relevant factors involved in the pathogenesis of the disease that may provide new therapeutic targets.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>21467843</pmid><doi>10.4161/cc.10.9.15487</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1538-4101 |
| ispartof | Cell cycle (Georgetown, Tex.), 2011-05, Vol.10 (9), p.1448-1455 |
| issn | 1538-4101 1551-4005 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3117044 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Binding Biology Bioscience Bone Marrow Transplantation - immunology Bone Marrow Transplantation - pathology Calcium Cancer Cell Chagas Cardiomyopathy - genetics Chagas Cardiomyopathy - immunology Chagas Cardiomyopathy - therapy Chronic Disease Cycle Disease Models, Animal Female Fibrosis Galectin 3 - genetics Gene Expression Profiling - methods Gene Expression Regulation - immunology Landes Male Mice Mice, Inbred C57BL Myocardium - immunology Myocardium - metabolism Myocardium - pathology Oligonucleotide Array Sequence Analysis Organogenesis Proteins Syndecan-4 - genetics Trypanosoma cruzi - classification Trypanosoma cruzi - immunology Trypanosoma cruzi - pathogenicity von Willebrand Factor - genetics |
| title | Reversion of gene expression alterations in hearts of mice with chronic chagasic cardiomyopathy after transplantation of bone marrow cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T08%3A23%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reversion%20of%20gene%20expression%20alterations%20in%20hearts%20of%20mice%20with%20chronic%20chagasic%20cardiomyopathy%20after%20transplantation%20of%20bone%20marrow%20cells&rft.jtitle=Cell%20cycle%20(Georgetown,%20Tex.)&rft.au=Soares,%20Milena%20B.P.&rft.date=2011-05-01&rft.volume=10&rft.issue=9&rft.spage=1448&rft.epage=1455&rft.pages=1448-1455&rft.issn=1538-4101&rft.eissn=1551-4005&rft_id=info:doi/10.4161/cc.10.9.15487&rft_dat=%3Cproquest_pubme%3E868030074%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=868030074&rft_id=info:pmid/21467843&rfr_iscdi=true |