Autonomous in Vitro Anticancer Drug Release from Mesoporous Silica Nanoparticles by pH-Sensitive Nanovalves

Mesoporous silica nanoparticles (MSNP) have proven to be an extremely effective solid support for controlled drug delivery on account of the fact that their surfaces can be easily functionalized in order to control the nanopore openings. We have described recently a series of mechanized silica nanop...

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Veröffentlicht in:	Journal of the American Chemical Society 2010-09, Vol.132 (36), p.12690-12697
Hauptverfasser:	Meng, Huan, Xue, Min, Xia, Tian, Zhao, Yan-Li, Tamanoi, Fuyuhiko, Stoddart, J. Fraser, Zink, Jeffrey I, Nel, Andre E
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology beta-Cyclodextrins - chemistry Cell Death - drug effects Cell Proliferation - drug effects Cells, Cultured Drug Delivery Systems Drug Screening Assays, Antitumor Humans Hydrogen-Ion Concentration Mice Nanostructures - chemistry Particle Size Porosity Silicon Dioxide - chemistry Surface Properties
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