Nogo-B receptor is necessary for cellular dolichol biosynthesis and protein N-glycosylation

Dolichol monophosphate (Dol‐P) functions as an obligate glycosyl carrier lipid in protein glycosylation reactions. Dol‐P is synthesized by the successive condensation of isopentenyl diphosphate (IPP), with farnesyl diphosphate catalysed by a cis ‐isoprenyltransferase ( cis ‐IPTase) activity. Despite...

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Veröffentlicht in:	The EMBO journal 2011-06, Vol.30 (12), p.2490-2500
Hauptverfasser:	Harrison, Kenneth D, Park, Eon Joo, Gao, Ningguo, Kuo, Andrew, Rush, Jeffrey S, Waechter, Charles J, Lehrman, Mark A, Sessa, William C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkyl and Aryl Transferases - antagonists & inhibitors Alkyl and Aryl Transferases - deficiency Alkyl and Aryl Transferases - metabolism Animals Biosynthesis Carrier Proteins - metabolism Cellular biology Cercopithecus aethiops cis-IPTase Cloning COS Cells dolichol Dolichol - biosynthesis Dolichol - deficiency Dolichol Phosphates - biosynthesis Dolichol Phosphates - deficiency EMBO20 EMBO21 Enzyme Activation - genetics Glycoproteins - metabolism Glycosylation Humans Mammals N-glycosylation Neurons protein Protein Conformation Proteins Receptors, Cell Surface - chemistry Receptors, Cell Surface - deficiency Receptors, Cell Surface - physiology
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