eIF2A mediates translation of hepatitis C viral mRNA under stress conditions

Translation of most mRNAs is suppressed under stress conditions. Phosphorylation of the α‐subunit of eukaryotic translation initiation factor 2 (eIF2), which delivers initiator tRNA (Met‐tRNA i ) to the P site of the 40S ribosomal subunit, is responsible for such translational suppression. However,...

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Veröffentlicht in:	The EMBO journal 2011-06, Vol.30 (12), p.2454-2464
Hauptverfasser:	Kim, Joon Hyun, Park, Sung Mi, Park, Ji Hoon, Keum, Sun Ju, Jang, Sung Key
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor eIF2A EMBO23 EMBO31 Eukaryotic Initiation Factor-2 - physiology HCV HeLa Cells Hepacivirus - genetics Hepacivirus - metabolism Hepatitis Hepatitis C - genetics Hepatitis C - metabolism Hepatitis C virus Humans IRES Mutagenesis, Insertional Phosphorylation Protein Biosynthesis - genetics Protein Interaction Domains and Motifs - genetics Protein Interaction Mapping - methods Ribonucleic acid Ribosome Subunits, Small, Eukaryotic - genetics Ribosome Subunits, Small, Eukaryotic - metabolism RNA RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Viral - genetics RNA, Viral - metabolism stress Stress analysis Stress, Physiological - genetics translation
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