Chiral Magnesium BINOL Phosphate-Catalyzed Phosphination of Imines: Access to Enantioenriched α-Amino Phosphine Oxides

A new method to synthesize chiral α-amino phosphine oxides is reported. The reaction combines N-substituted imines and diphenylphosphine oxide and is catalyzed by a chiral magnesium phosphate salt. A wide variety of aliphatic and aromatic aldimines substituted by electron-neutral benzhydryl or diben...

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Veröffentlicht in:	Organic letters 2011-04, Vol.13 (8), p.2054-2057
Hauptverfasser:	Ingle, Gajendrasingh K, Liang, Yuxue, Mormino, Michael G, Li, Guilong, Fronczek, Frank R, Antilla, Jon C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemistry Catalysis Imines - chemistry Magnesium - chemistry Molecular Structure Naphthols - chemistry Organophosphorus Compounds - chemistry Oxides - chemistry Phosphines - chemistry Stereoisomerism
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