Sterile inflammation: sensing and reacting to damage

Key Points Sterile inflammation occurs in the absence of microorganisms and is typically associated with the recognition of intracellular contents released from damaged and necrotic cells (also known as damage-associated molecular patterns) by inflammatory signalling receptors. Sterile inflammation...

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Veröffentlicht in:	Nature reviews. Immunology 2010-12, Vol.10 (12), p.826-837
Hauptverfasser:	Chen, Grace Y, Nuñez, Gabriel
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/127 631/250/256 631/250/262/2106 Alzheimer's disease Animals Atherosclerosis Biomedical and Life Sciences Biomedicine Blood vessels Cell death Chemokines Cytokines Cytokines - immunology Development and progression Diabetes Mellitus, Type 2 - immunology Disease Fibroblasts Growth factors Health aspects Heart attacks Humans Hypoxia Immune response Immunity, Innate Immunology Infections Inflammation Inflammation - immunology Inflammation Mediators - immunology Ischemia Leukocytes Macrophages Mice Microorganisms Neutrophils Pathogens Pattern recognition Reactive Oxygen Species - immunology Reactive Oxygen Species - toxicity Receptors, Pattern Recognition - immunology Reperfusion Injury - immunology review-article Risk factors Signal Transduction - immunology Tumor necrosis factor Tumor necrosis factor-TNF
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