Serum Carotenoids and Fat-Soluble Vitamins in Women With Type 1 Diabetes and Preeclampsia: A longitudinal study
OBJECTIVE: Increased oxidative stress and immune dysfunction are implicated in preeclampsia (PE) and may contribute to the two- to fourfold increase in PE prevalence among women with type 1 diabetes. Prospective measures of fat-soluble vitamins in diabetic pregnancy are therefore of interest. RESEAR...
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| Veröffentlicht in: | Diabetes care 2011-06, Vol.34 (6), p.1258-1264 |
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| creator | Azar, Madona Basu, Arpita Jenkins, Alicia J Nankervis, Alison J Hanssen, Kristian F Scholz, Hanne Henriksen, Tore Garg, Satish K Hammad, Samar M Scardo, James A Aston, Christopher E Lyons, Timothy J |
| description | OBJECTIVE: Increased oxidative stress and immune dysfunction are implicated in preeclampsia (PE) and may contribute to the two- to fourfold increase in PE prevalence among women with type 1 diabetes. Prospective measures of fat-soluble vitamins in diabetic pregnancy are therefore of interest. RESEARCH DESIGN AND METHODS: Maternal serum carotenoids (α- and β-carotene, lycopene, and lutein) and vitamins A, D, and E (α- and γ-tocopherols) were measured at first (12.2 ± 1.9 weeks [mean ± SD], visit 1), second (21.6 ± 1.5 weeks, visit 2), and third (31.5 ± 1.7 weeks, visit 3) trimesters of pregnancy in 23 women with type 1 diabetes who subsequently developed PE (DM PE+) and 24 women with type 1 diabetes, matched for age, diabetes duration, HbA₁c, and parity, who did not develop PE (DM PE-). Data were analyzed without and with adjustment for baseline differences in BMI, HDL cholesterol, and prandial status. RESULTS: In unadjusted analysis, in DM PE+ versus DM PE-, α-carotene and β-carotene were 45 and 53% lower, respectively, at visit 3 (P < 0.05), before PE onset. In adjusted analyses, the difference in β-carotene at visit 3 remained significant. Most participants were vitamin D deficient ( |
| doi_str_mv | 10.2337/dc10-2145 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3114346</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A259679433</galeid><sourcerecordid>A259679433</sourcerecordid><originalsourceid>FETCH-LOGICAL-f451t-9fdef1ac77b33e7a7bef6722179c048254719d09a869082b0414011f615d83af3</originalsourceid><addsrcrecordid>eNpt0luP1CAUAGBiNO44-uAfUKIxPnWFQkvxwWQyumqyiSazq4_NaXvosqEwW1qT-feyznhZM4EAge8cLoGQp5yd5kKoN13LWZZzWdwjC65FkRWFrO6TBeNSZ4XW-Ql5FOM1Y0zKqnpITpLVlaqKBQkbHOeBrmEME_pgu0jBd_QMpmwT3Nw4pN_sBIP1kVpPv4cBU2unK3qx2yLl9L2FBifch30dEVsHwzZaeEtX1AXf22nurAdHYxrsHpMHBlzEJ4d-SS7PPlysP2XnXz5-Xq_OMyMLPmXadGg4tEo1QqAC1aApVZ5zpVsmq7yQiuuOaahKzaq8YZJLxrkpedFVAoxYknf7vNu5GbBr0U8juHo72gHGXR3A1ndXvL2q-_CjFpxLIcuU4PUhwRhuZoxTPdjYonPgMcyxvt2YMZHqkrz4T16HeUw3TkgJIZX-hV7uUQ8Oa-tNSLu2tynrVV7oUmkpRFLZEdWjx3TE4NHYNH3Hnx7xqXQ42PZowLN_n-XPe_z-EAm8OgCILTgzgm9t_OtkKkrx5J7vnYFQQz8mc7nJ04djjBclV5X4CcRuymM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>873347900</pqid></control><display><type>article</type><title>Serum Carotenoids and Fat-Soluble Vitamins in Women With Type 1 Diabetes and Preeclampsia: A longitudinal study</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><creator>Azar, Madona ; Basu, Arpita ; Jenkins, Alicia J ; Nankervis, Alison J ; Hanssen, Kristian F ; Scholz, Hanne ; Henriksen, Tore ; Garg, Satish K ; Hammad, Samar M ; Scardo, James A ; Aston, Christopher E ; Lyons, Timothy J</creator><creatorcontrib>Azar, Madona ; Basu, Arpita ; Jenkins, Alicia J ; Nankervis, Alison J ; Hanssen, Kristian F ; Scholz, Hanne ; Henriksen, Tore ; Garg, Satish K ; Hammad, Samar M ; Scardo, James A ; Aston, Christopher E ; Lyons, Timothy J</creatorcontrib><description>OBJECTIVE: Increased oxidative stress and immune dysfunction are implicated in preeclampsia (PE) and may contribute to the two- to fourfold increase in PE prevalence among women with type 1 diabetes. Prospective measures of fat-soluble vitamins in diabetic pregnancy are therefore of interest. RESEARCH DESIGN AND METHODS: Maternal serum carotenoids (α- and β-carotene, lycopene, and lutein) and vitamins A, D, and E (α- and γ-tocopherols) were measured at first (12.2 ± 1.9 weeks [mean ± SD], visit 1), second (21.6 ± 1.5 weeks, visit 2), and third (31.5 ± 1.7 weeks, visit 3) trimesters of pregnancy in 23 women with type 1 diabetes who subsequently developed PE (DM PE+) and 24 women with type 1 diabetes, matched for age, diabetes duration, HbA₁c, and parity, who did not develop PE (DM PE-). Data were analyzed without and with adjustment for baseline differences in BMI, HDL cholesterol, and prandial status. RESULTS: In unadjusted analysis, in DM PE+ versus DM PE-, α-carotene and β-carotene were 45 and 53% lower, respectively, at visit 3 (P < 0.05), before PE onset. In adjusted analyses, the difference in β-carotene at visit 3 remained significant. Most participants were vitamin D deficient (<20 ng/mL), and vitamin D levels were lower in DM PE+ versus DM PE- throughout the pregnancy, although this did not reach statistical significance. CONCLUSIONS: In pregnant women with type 1 diabetes, low serum α- and β-carotene were associated with subsequent development of PE, and vitamin D deficiency may also be implicated.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc10-2145</identifier><identifier>PMID: 21498785</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>alpha-carotene ; Beta carotene ; beta Carotene - blood ; Biological and medical sciences ; blood serum ; body mass index ; Carotenoids - blood ; Chromophores ; Diabetes ; Diabetes Mellitus, Type 1 - blood ; Diabetes. Impaired glucose tolerance ; Diabetics ; Diet therapy ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; high density lipoprotein cholesterol ; Humans ; insulin-dependent diabetes mellitus ; Longitudinal Studies ; lutein ; Lycopene ; Medical sciences ; Metabolic diseases ; Miscellaneous ; Nutrition ; Original Research ; oxidative stress ; pre-eclampsia ; Pre-Eclampsia - blood ; Preeclampsia ; Pregnancy ; Pregnancy in Diabetics - blood ; pregnant women ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Studies ; Tocopherols ; Vitamin A - blood ; vitamin D ; Vitamin D - blood ; vitamin D deficiency ; Women ; Womens health</subject><ispartof>Diabetes care, 2011-06, Vol.34 (6), p.1258-1264</ispartof><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 American Diabetes Association</rights><rights>Copyright American Diabetes Association Jun 2011</rights><rights>2011 by the American Diabetes Association. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24242771$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21498785$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Azar, Madona</creatorcontrib><creatorcontrib>Basu, Arpita</creatorcontrib><creatorcontrib>Jenkins, Alicia J</creatorcontrib><creatorcontrib>Nankervis, Alison J</creatorcontrib><creatorcontrib>Hanssen, Kristian F</creatorcontrib><creatorcontrib>Scholz, Hanne</creatorcontrib><creatorcontrib>Henriksen, Tore</creatorcontrib><creatorcontrib>Garg, Satish K</creatorcontrib><creatorcontrib>Hammad, Samar M</creatorcontrib><creatorcontrib>Scardo, James A</creatorcontrib><creatorcontrib>Aston, Christopher E</creatorcontrib><creatorcontrib>Lyons, Timothy J</creatorcontrib><title>Serum Carotenoids and Fat-Soluble Vitamins in Women With Type 1 Diabetes and Preeclampsia: A longitudinal study</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>OBJECTIVE: Increased oxidative stress and immune dysfunction are implicated in preeclampsia (PE) and may contribute to the two- to fourfold increase in PE prevalence among women with type 1 diabetes. Prospective measures of fat-soluble vitamins in diabetic pregnancy are therefore of interest. RESEARCH DESIGN AND METHODS: Maternal serum carotenoids (α- and β-carotene, lycopene, and lutein) and vitamins A, D, and E (α- and γ-tocopherols) were measured at first (12.2 ± 1.9 weeks [mean ± SD], visit 1), second (21.6 ± 1.5 weeks, visit 2), and third (31.5 ± 1.7 weeks, visit 3) trimesters of pregnancy in 23 women with type 1 diabetes who subsequently developed PE (DM PE+) and 24 women with type 1 diabetes, matched for age, diabetes duration, HbA₁c, and parity, who did not develop PE (DM PE-). Data were analyzed without and with adjustment for baseline differences in BMI, HDL cholesterol, and prandial status. RESULTS: In unadjusted analysis, in DM PE+ versus DM PE-, α-carotene and β-carotene were 45 and 53% lower, respectively, at visit 3 (P < 0.05), before PE onset. In adjusted analyses, the difference in β-carotene at visit 3 remained significant. Most participants were vitamin D deficient (<20 ng/mL), and vitamin D levels were lower in DM PE+ versus DM PE- throughout the pregnancy, although this did not reach statistical significance. CONCLUSIONS: In pregnant women with type 1 diabetes, low serum α- and β-carotene were associated with subsequent development of PE, and vitamin D deficiency may also be implicated.</description><subject>alpha-carotene</subject><subject>Beta carotene</subject><subject>beta Carotene - blood</subject><subject>Biological and medical sciences</subject><subject>blood serum</subject><subject>body mass index</subject><subject>Carotenoids - blood</subject><subject>Chromophores</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetics</subject><subject>Diet therapy</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>high density lipoprotein cholesterol</subject><subject>Humans</subject><subject>insulin-dependent diabetes mellitus</subject><subject>Longitudinal Studies</subject><subject>lutein</subject><subject>Lycopene</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Miscellaneous</subject><subject>Nutrition</subject><subject>Original Research</subject><subject>oxidative stress</subject><subject>pre-eclampsia</subject><subject>Pre-Eclampsia - blood</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy in Diabetics - blood</subject><subject>pregnant women</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Studies</subject><subject>Tocopherols</subject><subject>Vitamin A - blood</subject><subject>vitamin D</subject><subject>Vitamin D - blood</subject><subject>vitamin D deficiency</subject><subject>Women</subject><subject>Womens health</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0luP1CAUAGBiNO44-uAfUKIxPnWFQkvxwWQyumqyiSazq4_NaXvosqEwW1qT-feyznhZM4EAge8cLoGQp5yd5kKoN13LWZZzWdwjC65FkRWFrO6TBeNSZ4XW-Ql5FOM1Y0zKqnpITpLVlaqKBQkbHOeBrmEME_pgu0jBd_QMpmwT3Nw4pN_sBIP1kVpPv4cBU2unK3qx2yLl9L2FBifch30dEVsHwzZaeEtX1AXf22nurAdHYxrsHpMHBlzEJ4d-SS7PPlysP2XnXz5-Xq_OMyMLPmXadGg4tEo1QqAC1aApVZ5zpVsmq7yQiuuOaahKzaq8YZJLxrkpedFVAoxYknf7vNu5GbBr0U8juHo72gHGXR3A1ndXvL2q-_CjFpxLIcuU4PUhwRhuZoxTPdjYonPgMcyxvt2YMZHqkrz4T16HeUw3TkgJIZX-hV7uUQ8Oa-tNSLu2tynrVV7oUmkpRFLZEdWjx3TE4NHYNH3Hnx7xqXQ42PZowLN_n-XPe_z-EAm8OgCILTgzgm9t_OtkKkrx5J7vnYFQQz8mc7nJ04djjBclV5X4CcRuymM</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Azar, Madona</creator><creator>Basu, Arpita</creator><creator>Jenkins, Alicia J</creator><creator>Nankervis, Alison J</creator><creator>Hanssen, Kristian F</creator><creator>Scholz, Hanne</creator><creator>Henriksen, Tore</creator><creator>Garg, Satish K</creator><creator>Hammad, Samar M</creator><creator>Scardo, James A</creator><creator>Aston, Christopher E</creator><creator>Lyons, Timothy J</creator><general>American Diabetes Association</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110601</creationdate><title>Serum Carotenoids and Fat-Soluble Vitamins in Women With Type 1 Diabetes and Preeclampsia: A longitudinal study</title><author>Azar, Madona ; Basu, Arpita ; Jenkins, Alicia J ; Nankervis, Alison J ; Hanssen, Kristian F ; Scholz, Hanne ; Henriksen, Tore ; Garg, Satish K ; Hammad, Samar M ; Scardo, James A ; Aston, Christopher E ; Lyons, Timothy J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f451t-9fdef1ac77b33e7a7bef6722179c048254719d09a869082b0414011f615d83af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>alpha-carotene</topic><topic>Beta carotene</topic><topic>beta Carotene - blood</topic><topic>Biological and medical sciences</topic><topic>blood serum</topic><topic>body mass index</topic><topic>Carotenoids - blood</topic><topic>Chromophores</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetics</topic><topic>Diet therapy</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>high density lipoprotein cholesterol</topic><topic>Humans</topic><topic>insulin-dependent diabetes mellitus</topic><topic>Longitudinal Studies</topic><topic>lutein</topic><topic>Lycopene</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Miscellaneous</topic><topic>Nutrition</topic><topic>Original Research</topic><topic>oxidative stress</topic><topic>pre-eclampsia</topic><topic>Pre-Eclampsia - blood</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy in Diabetics - blood</topic><topic>pregnant women</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Studies</topic><topic>Tocopherols</topic><topic>Vitamin A - blood</topic><topic>vitamin D</topic><topic>Vitamin D - blood</topic><topic>vitamin D deficiency</topic><topic>Women</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Azar, Madona</creatorcontrib><creatorcontrib>Basu, Arpita</creatorcontrib><creatorcontrib>Jenkins, Alicia J</creatorcontrib><creatorcontrib>Nankervis, Alison J</creatorcontrib><creatorcontrib>Hanssen, Kristian F</creatorcontrib><creatorcontrib>Scholz, Hanne</creatorcontrib><creatorcontrib>Henriksen, Tore</creatorcontrib><creatorcontrib>Garg, Satish K</creatorcontrib><creatorcontrib>Hammad, Samar M</creatorcontrib><creatorcontrib>Scardo, James A</creatorcontrib><creatorcontrib>Aston, Christopher E</creatorcontrib><creatorcontrib>Lyons, Timothy J</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Azar, Madona</au><au>Basu, Arpita</au><au>Jenkins, Alicia J</au><au>Nankervis, Alison J</au><au>Hanssen, Kristian F</au><au>Scholz, Hanne</au><au>Henriksen, Tore</au><au>Garg, Satish K</au><au>Hammad, Samar M</au><au>Scardo, James A</au><au>Aston, Christopher E</au><au>Lyons, Timothy J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Carotenoids and Fat-Soluble Vitamins in Women With Type 1 Diabetes and Preeclampsia: A longitudinal study</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>34</volume><issue>6</issue><spage>1258</spage><epage>1264</epage><pages>1258-1264</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>OBJECTIVE: Increased oxidative stress and immune dysfunction are implicated in preeclampsia (PE) and may contribute to the two- to fourfold increase in PE prevalence among women with type 1 diabetes. Prospective measures of fat-soluble vitamins in diabetic pregnancy are therefore of interest. RESEARCH DESIGN AND METHODS: Maternal serum carotenoids (α- and β-carotene, lycopene, and lutein) and vitamins A, D, and E (α- and γ-tocopherols) were measured at first (12.2 ± 1.9 weeks [mean ± SD], visit 1), second (21.6 ± 1.5 weeks, visit 2), and third (31.5 ± 1.7 weeks, visit 3) trimesters of pregnancy in 23 women with type 1 diabetes who subsequently developed PE (DM PE+) and 24 women with type 1 diabetes, matched for age, diabetes duration, HbA₁c, and parity, who did not develop PE (DM PE-). Data were analyzed without and with adjustment for baseline differences in BMI, HDL cholesterol, and prandial status. RESULTS: In unadjusted analysis, in DM PE+ versus DM PE-, α-carotene and β-carotene were 45 and 53% lower, respectively, at visit 3 (P < 0.05), before PE onset. In adjusted analyses, the difference in β-carotene at visit 3 remained significant. Most participants were vitamin D deficient (<20 ng/mL), and vitamin D levels were lower in DM PE+ versus DM PE- throughout the pregnancy, although this did not reach statistical significance. CONCLUSIONS: In pregnant women with type 1 diabetes, low serum α- and β-carotene were associated with subsequent development of PE, and vitamin D deficiency may also be implicated.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>21498785</pmid><doi>10.2337/dc10-2145</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetes care, 2011-06, Vol.34 (6), p.1258-1264 |
| issn | 0149-5992 1935-5548 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | alpha-carotene Beta carotene beta Carotene - blood Biological and medical sciences blood serum body mass index Carotenoids - blood Chromophores Diabetes Diabetes Mellitus, Type 1 - blood Diabetes. Impaired glucose tolerance Diabetics Diet therapy Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female high density lipoprotein cholesterol Humans insulin-dependent diabetes mellitus Longitudinal Studies lutein Lycopene Medical sciences Metabolic diseases Miscellaneous Nutrition Original Research oxidative stress pre-eclampsia Pre-Eclampsia - blood Preeclampsia Pregnancy Pregnancy in Diabetics - blood pregnant women Public health. Hygiene Public health. Hygiene-occupational medicine Studies Tocopherols Vitamin A - blood vitamin D Vitamin D - blood vitamin D deficiency Women Womens health |
| title | Serum Carotenoids and Fat-Soluble Vitamins in Women With Type 1 Diabetes and Preeclampsia: A longitudinal study |
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