Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

Increasing evidence indicates that endoplasmic reticulum (ER) stress activates the adaptive unfolded protein response (UPR), but that beyond a certain degree of ER damage, this response triggers apoptotic pathways. The general mechanisms of the UPR and its apoptotic pathways are well characterized....

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Veröffentlicht in:	Journal of cell science 2011-07, Vol.124 (Pt 13), p.2143-2152
Hauptverfasser:	Bravo, Roberto, Vicencio, Jose Miguel, Parra, Valentina, Troncoso, Rodrigo, Munoz, Juan Pablo, Bui, Michael, Quiroga, Clara, Rodriguez, Andrea E, Verdejo, Hugo E, Ferreira, Jorge, Iglewski, Myriam, Chiong, Mario, Simmen, Thomas, Zorzano, Antonio, Hill, Joseph A, Rothermel, Beverly A, Szabadkai, Gyorgy, Lavandero, Sergio
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Apoptosis - physiology Calcium - metabolism Cell Respiration Endoplasmic Reticulum - metabolism Energy Metabolism Enzyme Inhibitors - pharmacology HeLa Cells Histamine Agonists - pharmacology Humans Membrane Potential, Mitochondrial Mitochondria - metabolism Oxygen Consumption - drug effects Phosphatidylinositol Phosphates - metabolism Signal Transduction - physiology Stress, Physiological
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