Disruption of the Apelin-APJ System Worsens Hypoxia-Induced Pulmonary Hypertension

OBJECTIVE—The G-protein–coupled receptor APJ and its ligand apelin are highly expressed in the pulmonary vasculature, but their function in this vascular bed is unclear. We hypothesized that disruption of apelin signaling would lead to worsening of the vascular remodeling associated with pulmonary h...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2011-04, Vol.31 (4), p.814-820
Hauptverfasser:	Chandra, Suparna M, Razavi, Hedi, Kim, Jongmin, Agrawal, Rani, Kundu, Ramendra K, de Jesus Perez, Vinicio, Zamanian, Roham T, Quertermous, Thomas, Chun, Hyung J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipokines Adult AMP-Activated Protein Kinases - metabolism Animals Apelin Apelin Receptors Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Carrier Proteins - genetics Carrier Proteins - metabolism Case-Control Studies Cells, Cultured Disease Models, Animal Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Humans Hypertension, Pulmonary - diagnostic imaging Hypertension, Pulmonary - etiology Hypertension, Pulmonary - genetics Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - physiopathology Hypoxia - complications Hypoxia - genetics Hypoxia - metabolism Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Kruppel-Like Transcription Factors - metabolism Male Medical sciences Mice Mice, 129 Strain Mice, Knockout Middle Aged Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Phosphorylation Pneumology Pulmonary Artery - diagnostic imaging Pulmonary Artery - metabolism Pulmonary Artery - physiopathology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Receptors, G-Protein-Coupled - blood Receptors, G-Protein-Coupled - metabolism Severity of Illness Index Signal Transduction X-Ray Microtomography
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