Influence of multidrug efflux systems on methylene blue-mediated photodynamic inactivation of Candida albicans

Objectives To investigate whether the major fungal multidrug efflux systems (MESs) affect the efficiency of methylene blue (MB)-mediated antimicrobial photodynamic inactivation (APDI) in pathogenic fungi and test specific inhibitors of these efflux systems to potentiate APDI. Methods Candida albican...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2011-07, Vol.66 (7), p.1525-1532
Hauptverfasser:	Prates, Renato A., Kato, Ilka T., Ribeiro, Martha S., Tegos, George P., Hamblin, Michael R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Agents - metabolism Antifungal Agents - toxicity ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette Transporters - metabolism Biological and medical sciences Candida albicans Candida albicans - drug effects Candida albicans - metabolism Cytoplasm Fungi Gene expression Humans Medical sciences Methylene Blue - metabolism Methylene Blue - toxicity Microbial Viability - drug effects Microscopy Microscopy, Confocal Original Research Pharmacology. Drug treatments Photodynamic therapy Photosensitizing Agents - metabolism Photosensitizing Agents - toxicity
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