Cyclic nucleotide phosphodiesterase 7B mRNA: An unfavorable characteristic in chronic lymphocytic leukemia

A cost‐ and time‐efficient means to define the prognosis of patients with chronic lymphocytic leukemia (CLL) is desirable but does not yet exist. On the basis of the evidence that CLL cells have enhanced expression of the cyclic nucleotide phosphodiesterase isoform 7B (PDE7B), we hypothesized that P...

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Veröffentlicht in:	International journal of cancer 2011-09, Vol.129 (5), p.1162-1169
Hauptverfasser:	Zhang, Lingzhi, Murray, Fiona, Rassenti, Laura Z., Pu, Minya, Kelly, Colleen, Kanter, Joan R., Greaves, Andrew, Messer, Karen, Kipps, Thomas J., Insel, Paul A.
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-nucleotide phosphodiesterase Adult Aged Biological and medical sciences biomarkers Case-Control Studies CD38 antigen Chronic lymphatic leukemia chronic lymphocytic leukemia cyclic nucleotide phosphodiesterase 7B Cyclic Nucleotide Phosphodiesterases, Type 7 - genetics Cyclic Nucleotide Phosphodiesterases, Type 7 - metabolism Disease Progression Female Follow-Up Studies Gene expression Hematologic and hematopoietic diseases Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin Heavy Chains - metabolism Immunoglobulin Variable Region - genetics Immunoglobulin Variable Region - metabolism Immunoglobulins Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Mutation Peripheral blood mononuclear cells Polymerase chain reaction Prognosis prognostic factor Protein kinase quantitative reverse transcriptase‐polymerase chain reaction (QPCR) Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Survival Rate Time Factors Tumors ZAP-70 protein ZAP-70 Protein-Tyrosine Kinase - genetics ZAP-70 Protein-Tyrosine Kinase - metabolism
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