Inhibitory effect of caffeine on pacemaker activity in the oviduct is mediated by cAMP‐regulated conductances

BACKGROUND AND PURPOSE Spontaneous electrical activity, termed slow waves, drives rhythmic, propulsive contractions in the smooth muscle of the oviduct (myosalpinx). Myosalpinx contractions cause egg transport through the oviduct. Agents that disrupt slow wave pacemaker activity will therefore disru...

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Veröffentlicht in:	British journal of pharmacology 2011-06, Vol.163 (4), p.745-754
Hauptverfasser:	Dixon, RE, Hwang, SJ, Britton, FC, Sanders, KM, Ward, SM
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - antagonists & inhibitors 1-Methyl-3-isobutylxanthine - pharmacology Adenylyl Cyclases - metabolism Animals ATP-Binding Cassette Transporters - biosynthesis Biological and medical sciences Biological Clocks - drug effects caffeine Caffeine - antagonists & inhibitors Caffeine - pharmacology cAMP Colforsin - pharmacology Cyclic AMP - metabolism Drug Interactions Female female reproductive tract Glyburide - pharmacology KATP KATP Channels - antagonists & inhibitors KATP Channels - biosynthesis KATP Channels - metabolism Medical sciences Membrane Potentials - drug effects Mice Mice, Inbred BALB C Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscular system myosalpinx oviduct Oviducts - drug effects Oviducts - metabolism Oviducts - physiology Pharmacology. Drug treatments Phosphodiesterase Inhibitors - pharmacology Pinacidil - pharmacology Potassium Potassium Channels, Inwardly Rectifying - biosynthesis Receptors, Drug - biosynthesis Research Papers smooth muscle Sulfonylurea Receptors
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