Paternal age and psychiatric disorders: Findings from a Dutch population registry
Abstract Background We measured the association between paternal age and schizophrenia (SCZ), autism spectrum disorders (ASD), major depressive disorder (MDD), and bipolar disorder (BPD) in the Dutch population. Methods In total, 14 231 patients and 56 924 matched controls were collected and analyze...
Gespeichert in:
| Veröffentlicht in: | Schizophrenia research 2011-07, Vol.129 (2), p.128-132 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 132 |
|---|---|
| container_issue | 2 |
| container_start_page | 128 |
| container_title | Schizophrenia research |
| container_volume | 129 |
| creator | Buizer-Voskamp, Jacobine E Laan, Wijnand Staal, Wouter G Hennekam, Eric A.M Aukes, Maartje F Termorshuizen, Fabian Kahn, René S Boks, Marco P.M Ophoff, Roel A |
| description | Abstract Background We measured the association between paternal age and schizophrenia (SCZ), autism spectrum disorders (ASD), major depressive disorder (MDD), and bipolar disorder (BPD) in the Dutch population. Methods In total, 14 231 patients and 56 924 matched controls were collected and analyzed for an association with paternal age by logistic regression. Results ASD is significantly associated with increased paternal age: Older fathers > 40 years of age have a 3.3 times increased odds of having a child with ASD compared to young fathers < 20 years of age. SCZ has significant associations for fathers aged > 35 years (OR = 1.27, 95% Confidence Interval: 1.05 and 1.53). For MDD, both younger and older fathers have increased odds. No association was found for BPD. Conclusions The effects of paternal age as a risk factor are different for ASD and SCZ on one hand, and the affective disorders on the other hand. Different types of association might indicate different biological or psychosocial mechanisms. Late paternity (associated with predispositions to psychiatric disorders) seems the most probable explanation for the association with paternal age. |
| doi_str_mv | 10.1016/j.schres.2011.03.021 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3110532</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0920996411001691</els_id><sourcerecordid>871005175</sourcerecordid><originalsourceid>FETCH-LOGICAL-c547t-adb38f0b446a13af94916eab666657bfc64a16165e3376eaf641c85789daa2ae3</originalsourceid><addsrcrecordid>eNqFUk1v1DAQjRCIbgv_AKFcEKcET_yRhAMSKrQgVQIEnK2JM9n1krUXO6m0_x5Hu7TABV98mDdvZt57WfYMWAkM1KttGc0mUCwrBlAyXrIKHmQrkDUvKsnah9mKtRUr2laJs-w8xi1jDCSrH2dnFYimraVcZV8-40TB4ZjjmnJ0fb6PB7OxOAVr8t5GH3oK8XV-ZV1v3TrmQ_C7HPN382Q2-d7v5xEn610eaG3jFA5PskcDjpGenv6L7PvV-2-XH4qbT9cfL9_eFEaKeiqw73gzsE4IhcBxaEULirBT6cm6G4wSCAqUJM7rVBiUANPIuml7xAqJX2Rvjrz7udtRb8hNAUe9D3aH4aA9Wv13xdmNXvtbzQGY5FUieHkiCP7nTHHSOxsNjSM68nPUTQ2MSahlQooj0gQfY6DhbgowvZiht_pohl7M0IzrZEZqe_7nhndNv9VPgBcnAEaD4xDQGRvvcaJSquXi_lRKet5aCmmaJWeot4HMpHtv_7fJvwRmtM6mmT_oQHHr5yUCUYOOlWb66xKcJTdJqcTZAv8Fjr_Adw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>871005175</pqid></control><display><type>article</type><title>Paternal age and psychiatric disorders: Findings from a Dutch population registry</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Buizer-Voskamp, Jacobine E ; Laan, Wijnand ; Staal, Wouter G ; Hennekam, Eric A.M ; Aukes, Maartje F ; Termorshuizen, Fabian ; Kahn, René S ; Boks, Marco P.M ; Ophoff, Roel A</creator><creatorcontrib>Buizer-Voskamp, Jacobine E ; Laan, Wijnand ; Staal, Wouter G ; Hennekam, Eric A.M ; Aukes, Maartje F ; Termorshuizen, Fabian ; Kahn, René S ; Boks, Marco P.M ; Ophoff, Roel A</creatorcontrib><description>Abstract Background We measured the association between paternal age and schizophrenia (SCZ), autism spectrum disorders (ASD), major depressive disorder (MDD), and bipolar disorder (BPD) in the Dutch population. Methods In total, 14 231 patients and 56 924 matched controls were collected and analyzed for an association with paternal age by logistic regression. Results ASD is significantly associated with increased paternal age: Older fathers > 40 years of age have a 3.3 times increased odds of having a child with ASD compared to young fathers < 20 years of age. SCZ has significant associations for fathers aged > 35 years (OR = 1.27, 95% Confidence Interval: 1.05 and 1.53). For MDD, both younger and older fathers have increased odds. No association was found for BPD. Conclusions The effects of paternal age as a risk factor are different for ASD and SCZ on one hand, and the affective disorders on the other hand. Different types of association might indicate different biological or psychosocial mechanisms. Late paternity (associated with predispositions to psychiatric disorders) seems the most probable explanation for the association with paternal age.</description><identifier>ISSN: 0920-9964</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/j.schres.2011.03.021</identifier><identifier>PMID: 21489755</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Bipolar disorder ; Bipolar Disorder - diagnosis ; Bipolar Disorder - epidemiology ; Bipolar disorders ; Case-Control Studies ; Child ; Child development disorders, pervasive ; Child Development Disorders, Pervasive - diagnosis ; Child Development Disorders, Pervasive - epidemiology ; Depression ; Depressive disorder, major ; Depressive Disorder, Major - diagnosis ; Depressive Disorder, Major - epidemiology ; Female ; Humans ; Logistic Models ; Male ; Medical sciences ; Mental Disorders - diagnosis ; Mental Disorders - epidemiology ; Middle Aged ; Mood disorders ; Netherlands - epidemiology ; Paternal Age ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Registries - statistics & numerical data ; Retrospective Studies ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - epidemiology ; Young Adult</subject><ispartof>Schizophrenia research, 2011-07, Vol.129 (2), p.128-132</ispartof><rights>Elsevier B.V.</rights><rights>2011 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><rights>2011 Elsevier B.V. All rights reserved. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-adb38f0b446a13af94916eab666657bfc64a16165e3376eaf641c85789daa2ae3</citedby><cites>FETCH-LOGICAL-c547t-adb38f0b446a13af94916eab666657bfc64a16165e3376eaf641c85789daa2ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.schres.2011.03.021$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24266934$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21489755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buizer-Voskamp, Jacobine E</creatorcontrib><creatorcontrib>Laan, Wijnand</creatorcontrib><creatorcontrib>Staal, Wouter G</creatorcontrib><creatorcontrib>Hennekam, Eric A.M</creatorcontrib><creatorcontrib>Aukes, Maartje F</creatorcontrib><creatorcontrib>Termorshuizen, Fabian</creatorcontrib><creatorcontrib>Kahn, René S</creatorcontrib><creatorcontrib>Boks, Marco P.M</creatorcontrib><creatorcontrib>Ophoff, Roel A</creatorcontrib><title>Paternal age and psychiatric disorders: Findings from a Dutch population registry</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>Abstract Background We measured the association between paternal age and schizophrenia (SCZ), autism spectrum disorders (ASD), major depressive disorder (MDD), and bipolar disorder (BPD) in the Dutch population. Methods In total, 14 231 patients and 56 924 matched controls were collected and analyzed for an association with paternal age by logistic regression. Results ASD is significantly associated with increased paternal age: Older fathers > 40 years of age have a 3.3 times increased odds of having a child with ASD compared to young fathers < 20 years of age. SCZ has significant associations for fathers aged > 35 years (OR = 1.27, 95% Confidence Interval: 1.05 and 1.53). For MDD, both younger and older fathers have increased odds. No association was found for BPD. Conclusions The effects of paternal age as a risk factor are different for ASD and SCZ on one hand, and the affective disorders on the other hand. Different types of association might indicate different biological or psychosocial mechanisms. Late paternity (associated with predispositions to psychiatric disorders) seems the most probable explanation for the association with paternal age.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - diagnosis</subject><subject>Bipolar Disorder - epidemiology</subject><subject>Bipolar disorders</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child development disorders, pervasive</subject><subject>Child Development Disorders, Pervasive - diagnosis</subject><subject>Child Development Disorders, Pervasive - epidemiology</subject><subject>Depression</subject><subject>Depressive disorder, major</subject><subject>Depressive Disorder, Major - diagnosis</subject><subject>Depressive Disorder, Major - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental Disorders - diagnosis</subject><subject>Mental Disorders - epidemiology</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Netherlands - epidemiology</subject><subject>Paternal Age</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Registries - statistics & numerical data</subject><subject>Retrospective Studies</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - epidemiology</subject><subject>Young Adult</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1v1DAQjRCIbgv_AKFcEKcET_yRhAMSKrQgVQIEnK2JM9n1krUXO6m0_x5Hu7TABV98mDdvZt57WfYMWAkM1KttGc0mUCwrBlAyXrIKHmQrkDUvKsnah9mKtRUr2laJs-w8xi1jDCSrH2dnFYimraVcZV8-40TB4ZjjmnJ0fb6PB7OxOAVr8t5GH3oK8XV-ZV1v3TrmQ_C7HPN382Q2-d7v5xEn610eaG3jFA5PskcDjpGenv6L7PvV-2-XH4qbT9cfL9_eFEaKeiqw73gzsE4IhcBxaEULirBT6cm6G4wSCAqUJM7rVBiUANPIuml7xAqJX2Rvjrz7udtRb8hNAUe9D3aH4aA9Wv13xdmNXvtbzQGY5FUieHkiCP7nTHHSOxsNjSM68nPUTQ2MSahlQooj0gQfY6DhbgowvZiht_pohl7M0IzrZEZqe_7nhndNv9VPgBcnAEaD4xDQGRvvcaJSquXi_lRKet5aCmmaJWeot4HMpHtv_7fJvwRmtM6mmT_oQHHr5yUCUYOOlWb66xKcJTdJqcTZAv8Fjr_Adw</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Buizer-Voskamp, Jacobine E</creator><creator>Laan, Wijnand</creator><creator>Staal, Wouter G</creator><creator>Hennekam, Eric A.M</creator><creator>Aukes, Maartje F</creator><creator>Termorshuizen, Fabian</creator><creator>Kahn, René S</creator><creator>Boks, Marco P.M</creator><creator>Ophoff, Roel A</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110701</creationdate><title>Paternal age and psychiatric disorders: Findings from a Dutch population registry</title><author>Buizer-Voskamp, Jacobine E ; Laan, Wijnand ; Staal, Wouter G ; Hennekam, Eric A.M ; Aukes, Maartje F ; Termorshuizen, Fabian ; Kahn, René S ; Boks, Marco P.M ; Ophoff, Roel A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-adb38f0b446a13af94916eab666657bfc64a16165e3376eaf641c85789daa2ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - diagnosis</topic><topic>Bipolar Disorder - epidemiology</topic><topic>Bipolar disorders</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child development disorders, pervasive</topic><topic>Child Development Disorders, Pervasive - diagnosis</topic><topic>Child Development Disorders, Pervasive - epidemiology</topic><topic>Depression</topic><topic>Depressive disorder, major</topic><topic>Depressive Disorder, Major - diagnosis</topic><topic>Depressive Disorder, Major - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental Disorders - diagnosis</topic><topic>Mental Disorders - epidemiology</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Netherlands - epidemiology</topic><topic>Paternal Age</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Registries - statistics & numerical data</topic><topic>Retrospective Studies</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buizer-Voskamp, Jacobine E</creatorcontrib><creatorcontrib>Laan, Wijnand</creatorcontrib><creatorcontrib>Staal, Wouter G</creatorcontrib><creatorcontrib>Hennekam, Eric A.M</creatorcontrib><creatorcontrib>Aukes, Maartje F</creatorcontrib><creatorcontrib>Termorshuizen, Fabian</creatorcontrib><creatorcontrib>Kahn, René S</creatorcontrib><creatorcontrib>Boks, Marco P.M</creatorcontrib><creatorcontrib>Ophoff, Roel A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buizer-Voskamp, Jacobine E</au><au>Laan, Wijnand</au><au>Staal, Wouter G</au><au>Hennekam, Eric A.M</au><au>Aukes, Maartje F</au><au>Termorshuizen, Fabian</au><au>Kahn, René S</au><au>Boks, Marco P.M</au><au>Ophoff, Roel A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paternal age and psychiatric disorders: Findings from a Dutch population registry</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>129</volume><issue>2</issue><spage>128</spage><epage>132</epage><pages>128-132</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>Abstract Background We measured the association between paternal age and schizophrenia (SCZ), autism spectrum disorders (ASD), major depressive disorder (MDD), and bipolar disorder (BPD) in the Dutch population. Methods In total, 14 231 patients and 56 924 matched controls were collected and analyzed for an association with paternal age by logistic regression. Results ASD is significantly associated with increased paternal age: Older fathers > 40 years of age have a 3.3 times increased odds of having a child with ASD compared to young fathers < 20 years of age. SCZ has significant associations for fathers aged > 35 years (OR = 1.27, 95% Confidence Interval: 1.05 and 1.53). For MDD, both younger and older fathers have increased odds. No association was found for BPD. Conclusions The effects of paternal age as a risk factor are different for ASD and SCZ on one hand, and the affective disorders on the other hand. Different types of association might indicate different biological or psychosocial mechanisms. Late paternity (associated with predispositions to psychiatric disorders) seems the most probable explanation for the association with paternal age.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>21489755</pmid><doi>10.1016/j.schres.2011.03.021</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0920-9964 |
| ispartof | Schizophrenia research, 2011-07, Vol.129 (2), p.128-132 |
| issn | 0920-9964 1573-2509 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3110532 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Adult and adolescent clinical studies Biological and medical sciences Bipolar disorder Bipolar Disorder - diagnosis Bipolar Disorder - epidemiology Bipolar disorders Case-Control Studies Child Child development disorders, pervasive Child Development Disorders, Pervasive - diagnosis Child Development Disorders, Pervasive - epidemiology Depression Depressive disorder, major Depressive Disorder, Major - diagnosis Depressive Disorder, Major - epidemiology Female Humans Logistic Models Male Medical sciences Mental Disorders - diagnosis Mental Disorders - epidemiology Middle Aged Mood disorders Netherlands - epidemiology Paternal Age Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Registries - statistics & numerical data Retrospective Studies Schizophrenia Schizophrenia - diagnosis Schizophrenia - epidemiology Young Adult |
| title | Paternal age and psychiatric disorders: Findings from a Dutch population registry |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T01%3A50%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Paternal%20age%20and%20psychiatric%20disorders:%20Findings%20from%20a%20Dutch%20population%20registry&rft.jtitle=Schizophrenia%20research&rft.au=Buizer-Voskamp,%20Jacobine%20E&rft.date=2011-07-01&rft.volume=129&rft.issue=2&rft.spage=128&rft.epage=132&rft.pages=128-132&rft.issn=0920-9964&rft.eissn=1573-2509&rft_id=info:doi/10.1016/j.schres.2011.03.021&rft_dat=%3Cproquest_pubme%3E871005175%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=871005175&rft_id=info:pmid/21489755&rft_els_id=1_s2_0_S0920996411001691&rfr_iscdi=true |