Role for Nox1 NADPH oxidase in atherosclerosis

Abstract Objective Examine the contribution of Nox1 NADPH oxidase to atherogenesis. Methods and results Male apolipoprotein E deficient mice (ApoE−/− ) and male mice deficient in both apolipoprotein E and Nox1 (ApoE−/− Nox1−/y ) received an atherogenic diet for 18 weeks. Mean blood pressures, body w...

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Veröffentlicht in:	Atherosclerosis 2011-06, Vol.216 (2), p.321-326
Hauptverfasser:	Sheehan, Andrea L, Carrell, Samuel, Johnson, Bryon, Stanic, Bojana, Banfi, Botond, Miller, Francis J
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Aorta, Thoracic - pathology apolipoprotein E Apolipoproteins E - genetics Associated diseases and complications atherogenesis Atherosclerosis Atherosclerosis (general aspects, experimental research) Atherosclerosis - enzymology Atherosclerosis - physiopathology Biological and medical sciences Blood and lymphatic vessels blood pressure blood serum body weight Cardiology. Vascular system Cardiovascular carotid arteries Carotid Arteries - surgery Cell Proliferation cholesterol Cholesterol - metabolism collagen Collagen - metabolism Diabetes. Impaired glucose tolerance diet Diet, Atherogenic Disease Models, Animal Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female hyperplasia Hyperplasia - pathology macrophages Male Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic NADH, NADPH Oxidoreductases - genetics NADH, NADPH Oxidoreductases - physiology NADP (coenzyme) NADPH oxidase NADPH Oxidase 1 Oxidative stress Superoxides - chemistry
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