The c-Myb target gene neuromedin U functions as a novel cofactor during the early stages of erythropoiesis

The requirement of c-Myb during erythropoiesis spurred an interest in identifying c-Myb target genes that are important for erythroid development. Here, we determined that the neuropeptide neuromedin U (NmU) is a c-Myb target gene. Silencing NmU, c-myb, or NmU's cognate receptor NMUR1 expressio...

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Veröffentlicht in:	Blood 2011-05, Vol.117 (21), p.5733-5743
Hauptverfasser:	Gambone, Julia E., Dusaban, Stephanie S., Loperena, Roxana, Nakata, Yuji, Shetzline, Susan E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Western Cell Differentiation Cells, Cultured Chromatin Immunoprecipitation Colony-Forming Units Assay Erythroblasts - metabolism Erythroid Precursor Cells - metabolism Erythropoiesis - physiology Flow Cytometry Fluorescent Antibody Technique Hematologic and hematopoietic diseases Humans Luciferases - metabolism Medical sciences Neuropeptides - antagonists & inhibitors Neuropeptides - genetics Neuropeptides - metabolism Peptide Fragments - pharmacology Proto-Oncogene Proteins c-myb - antagonists & inhibitors Proto-Oncogene Proteins c-myb - genetics Proto-Oncogene Proteins c-myb - metabolism Receptors, Neurotransmitter - antagonists & inhibitors Receptors, Neurotransmitter - genetics Receptors, Neurotransmitter - metabolism Red Cells, Iron, and Erythropoiesis Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Small Interfering - genetics
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