Frequent alternative splicing of human genes
Alternative splicing can produce variant proteins and expression patterns as different as the products of different genes, yet the prevalence of alternative splicing has not been quantified. Here the spliced alignment algorithm was used to make a first inventory of exon-intron structures of known hu...
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| Veröffentlicht in: | Genome research 1999-12, Vol.9 (12), p.1288-1293 |
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| container_title | Genome research |
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| creator | Mironov, A A Fickett, J W Gelfand, M S |
| description | Alternative splicing can produce variant proteins and expression patterns as different as the products of different genes, yet the prevalence of alternative splicing has not been quantified. Here the spliced alignment algorithm was used to make a first inventory of exon-intron structures of known human genes using EST contigs from the TIGR Human Gene Index. The results on any one gene may be incomplete and will require verification, yet the overall trends are significant. Evidence of alternative splicing was shown in 35% of genes and the majority of splicing events occurred in 5' untranslated regions, suggesting wide occurrence of alternative regulation. Most of the alternative splices of coding regions generated additional protein domains rather than alternating domains. |
| doi_str_mv | 10.1101/gr.9.12.1288 |
| format | Article |
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Most of the alternative splices of coding regions generated additional protein domains rather than alternating domains.</description><subject>5' Untranslated Regions - genetics</subject><subject>Alternative Splicing</subject><subject>Base Sequence - genetics</subject><subject>Contig Mapping - methods</subject><subject>Databases, Factual</subject><subject>Exons - genetics</subject><subject>Expressed Sequence Tags</subject><subject>Humans</subject><subject>Introns - genetics</subject><subject>Letter</subject><subject>Molecular Sequence Data</subject><subject>Protein Isoforms - genetics</subject><subject>Sequence Alignment</subject><issn>1088-9051</issn><issn>1549-5469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1Lw0AQhhdRbK3ePEtOnpq4k_3o7sGDFKtCwYuel91kkkbyUXeTgv_elBapMDAD88zMOy8ht0ATAAoPpU90AukYSp2RKQiuY8GlPh9rqlSsqYAJuQrhi1LKuFKXZAJUAlMCpmS-8vg9YNtHtu7Rt7avdhiFbV1lVVtGXRFthsa2UYkthmtyUdg64M0xz8jn6vlj-Rqv31_elk_rOONc9DEICUpYLl0uAZ3LCo1O25Q7QRlNQVOwKHLgKEWBWufIU3CpUNJRqwpgM_J42LsdXIN5NsrztjZbXzXW_5jOVuZ_p602pux2hgHVejHO3x_nfTc-F3rTVCHDurYtdkMwUjPF-EKO4PwAZr4LwWPxdwOo2btrSm-0gdTs3R3xu1NdJ_DBTvYLnV12BQ</recordid><startdate>199912</startdate><enddate>199912</enddate><creator>Mironov, A A</creator><creator>Fickett, J W</creator><creator>Gelfand, M S</creator><general>Cold Spring Harbor Laboratory Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199912</creationdate><title>Frequent alternative splicing of human genes</title><author>Mironov, A A ; Fickett, J W ; Gelfand, M S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-156185a46bd61ebbcf9eb9a24b503021901ae5d14e65fe99de421b2586b0a8f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>5' Untranslated Regions - genetics</topic><topic>Alternative Splicing</topic><topic>Base Sequence - genetics</topic><topic>Contig Mapping - methods</topic><topic>Databases, Factual</topic><topic>Exons - genetics</topic><topic>Expressed Sequence Tags</topic><topic>Humans</topic><topic>Introns - genetics</topic><topic>Letter</topic><topic>Molecular Sequence Data</topic><topic>Protein Isoforms - genetics</topic><topic>Sequence Alignment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mironov, A A</creatorcontrib><creatorcontrib>Fickett, J W</creatorcontrib><creatorcontrib>Gelfand, M S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genome research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mironov, A A</au><au>Fickett, J W</au><au>Gelfand, M S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frequent alternative splicing of human genes</atitle><jtitle>Genome research</jtitle><addtitle>Genome Res</addtitle><date>1999-12</date><risdate>1999</risdate><volume>9</volume><issue>12</issue><spage>1288</spage><epage>1293</epage><pages>1288-1293</pages><issn>1088-9051</issn><eissn>1549-5469</eissn><abstract>Alternative splicing can produce variant proteins and expression patterns as different as the products of different genes, yet the prevalence of alternative splicing has not been quantified. 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| fulltext | fulltext |
| identifier | ISSN: 1088-9051 |
| ispartof | Genome research, 1999-12, Vol.9 (12), p.1288-1293 |
| issn | 1088-9051 1549-5469 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_310997 |
| source | MEDLINE; PubMed Central; Alma/SFX Local Collection |
| subjects | 5' Untranslated Regions - genetics Alternative Splicing Base Sequence - genetics Contig Mapping - methods Databases, Factual Exons - genetics Expressed Sequence Tags Humans Introns - genetics Letter Molecular Sequence Data Protein Isoforms - genetics Sequence Alignment |
| title | Frequent alternative splicing of human genes |
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