High-resolution genetic and physical map of the Lgn1 interval in C57BL/6J implicates Naip2 or Naip5 in Legionella pneumophila pathogenesis

Prior genetic and physical mapping has shown that the Naip gene cluster on mouse chromosome 13D1-D3 contains a gene, Lgn1, that is responsible for determining the permissivity of ex vivo macrophages to Legionella pneumophila replication. We have identified differences in the structure of the Naip ar...

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Veröffentlicht in:	Genome research 2000-08, Vol.10 (8), p.1158-1171
Hauptverfasser:	Growney, J D, Dietrich, W F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Cell Line Genetic Predisposition to Disease - genetics Legionella pneumophila - genetics Legionella pneumophila - pathogenicity Legionnaires' Disease - etiology Legionnaires' Disease - genetics Letter Mice Mice, Inbred A Mice, Inbred C57BL Molecular Sequence Data Multigene Family - genetics Nerve Tissue Proteins - genetics Neuronal Apoptosis-Inhibitory Protein Physical Chromosome Mapping - methods
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