Time-dependent changes in the brain arachidonic acid cascade during cuprizone-induced demyelination and remyelination

Abstract Phospholipases A2 (PLA2 ) are the enzymatic keys for the activation of the arachidonic acid (AA) cascade and the subsequent synthesis of pro-inflammatory prostanoids (prostaglandins and tromboxanes). Prostanoids play critical roles in the initiation and modulation of inflammation and their...

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Veröffentlicht in:	Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2011-07, Vol.85 (1), p.29-35
Hauptverfasser:	Palumbo, S, Toscano, C.D, Parente, L, Weigert, R, Bosetti, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Arachidonic acid Arachidonic Acids - metabolism Astrocytes - drug effects Astrocytes - immunology Astrocytes - metabolism Astrocytes - pathology Biological and medical sciences Cerebral Cortex - drug effects Cerebral Cortex - immunology Cerebral Cortex - metabolism Cerebral Cortex - pathology Cuprizone Cuprizone - toxicity Cyclooxygenase 1 - genetics Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Demyelinating Diseases - chemically induced Demyelinating Diseases - immunology Demyelinating Diseases - metabolism Demyelination Eicosanoids Endocrinology & Metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Enzymologic - drug effects Group V Phospholipases A2 - genetics Group V Phospholipases A2 - metabolism Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Macrophages - pathology Male Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Microglia - drug effects Microglia - immunology Microglia - metabolism Microglia - pathology Multiple Sclerosis - immunology Multiple Sclerosis - metabolism Multiple Sclerosis - pathology Myelin Sheath - drug effects Myelin Sheath - immunology Myelin Sheath - metabolism Nerve Tissue Proteins - metabolism Neurons - drug effects Neurons - immunology Neurons - metabolism Phospholipases A 2 Phospholipases A2, Cytosolic - genetics Phospholipases A2, Cytosolic - metabolism RNA, Messenger - metabolism Time Factors Vertebrates: endocrinology
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