Enzymatic triggered release of an HIV-1 entry inhibitor from prostate specific antigen degradable microparticles

This paper describes the design, construction and characterization of the first anti-HIV drug delivery system that is triggered to release its contents in the presence of human semen. Microgel particles were synthesized with a crosslinker containing a peptide substrate for the seminal serine proteas...

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Veröffentlicht in:	International journal of pharmaceutics 2011-07, Vol.413 (1), p.10-18
Hauptverfasser:	Clark, Meredith R., Aliyar, Hyder A., Lee, Chang-won, Jay, Julie I., Gupta, Kavita M., Watson, Karen M., Stewart, Russell J., Buckheit, Robert W., Kiser, Patrick F.
Format:	Artikel
Sprache:	eng
Schlagworte:	antigens antiretroviral agents Biological and medical sciences Cross-Linking Reagents - chemical synthesis Drug Carriers - chemistry Drug Carriers - metabolism Drug Carriers - pharmacokinetics Drug Compounding Drug Delivery Systems drugs Excipients - chemistry Fluorescein-5-isothiocyanate - chemistry Fluorescein-5-isothiocyanate - metabolism Fluorescein-5-isothiocyanate - pharmacokinetics Gels - chemistry General pharmacology HeLa Cells HIV HIV Fusion Inhibitors - chemistry HIV Fusion Inhibitors - metabolism HIV Fusion Inhibitors - pharmacokinetics HIV Infections - prevention & control HIV-1 - metabolism Human immunodeficiency virus 1 Humans Male Medical sciences Microbicide Microgel Particle Size peptides Peptides - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments polymerization polymers Polystyrenes - chemistry Polystyrenes - metabolism Polystyrenes - pharmacology Prostate specific antigen Prostate-Specific Antigen - chemistry Prostate-Specific Antigen - metabolism Prostate-Specific Antigen - pharmacokinetics Semen Semen - metabolism seminal plasma serine proteinases sodium Triggered release
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