Ubiquitin–proteasome pathway and cellular responses to oxidative stress

The ubiquitin–proteasome pathway (UPP) is the primary cytosolic proteolytic machinery for the selective degradation of various forms of damaged proteins. Thus, the UPP is an important protein quality control mechanism. In the canonical UPP, both ubiquitin and the 26S proteasome are involved. Substra...

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Veröffentlicht in:	Free radical biology & medicine 2011-07, Vol.51 (1), p.5-16
Hauptverfasser:	Shang, Fu, Taylor, Allen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Free radicals Humans Oxidation-Reduction Oxidative Stress Proteasome proteasome endopeptidase complex Proteasome Endopeptidase Complex - metabolism Protein Binding Protein quality control proteolysis Ubiquitin Ubiquitin - metabolism ubiquitin-protein ligase ubiquitination
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