Pattern Separation: A Common Function for New Neurons in Hippocampus and Olfactory Bulb
While adult-born neurons in the olfactory bulb (OB) and the dentate gyrus (DG) subregion of the hippocampus have fundamentally different properties, they may have more in common than meets the eye. Here, we propose that new granule cells in the OB and DG may function as modulators of principal neuro...
Gespeichert in:
| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2011-05, Vol.70 (4), p.582-588 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 588 |
|---|---|
| container_issue | 4 |
| container_start_page | 582 |
| container_title | Neuron (Cambridge, Mass.) |
| container_volume | 70 |
| creator | Sahay, Amar Wilson, Donald A. Hen, René |
| description | While adult-born neurons in the olfactory bulb (OB) and the dentate gyrus (DG) subregion of the hippocampus have fundamentally different properties, they may have more in common than meets the eye. Here, we propose that new granule cells in the OB and DG may function as modulators of principal neurons to influence pattern separation and that adult neurogenesis constitutes an adaptive mechanism to optimally encode contextual or olfactory information. See the related Perspective from Aimone, Deng, and Gage, “Resolving New Memories: A Critical Look at the Dentate Gyrus, Adult Neurogenesis, and Pattern Separation,” in this issue of
Neuron. |
| doi_str_mv | 10.1016/j.neuron.2011.05.012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3109085</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S089662731100393X</els_id><sourcerecordid>874183781</sourcerecordid><originalsourceid>FETCH-LOGICAL-c588t-9258f4402d24ad8d2baefa78fe4905ee5cbd12164439f526f9c52e660b5efa343</originalsourceid><addsrcrecordid>eNqFkU9vFSEUxYnR2NfqNzCGxIWrGYEBBlyY1JfWmjTWRI1LwjB3lJcZGGGmpt9eXl6tfxa6ICTc3z33cg5CTyipKaHyxa4OsKYYakYorYmoCWX30IYS3Vacan0fbYjSspKsbY7Qcc47QigXmj5ER4xKohVtN-jze7sskAL-ALNNdvExvMSneBunKQZ8vga3f8JDTPgdfC9nPzJjH_CFn-fo7DSvGdvQ46txsG6J6Qa_XsfuEXow2DHD49v7BH06P_u4vagur9683Z5eVk4otVSaCTVwTljPuO1VzzoLg23VAFwTASBc19OyLeeNHgSTg3aCgZSkE4VreHOCXh1057WboHcQlmRHMyc_2XRjovXmz0rwX82XeG2aYhRRogg8vxVI8dsKeTGTzw7G0QaIazaq5VQ1raL_J6VqpSxsIZ_9Re7imkLxwdBCEK6VVoXiB8qlmHOC4W5rSsw-YrMzh4jNPmJDhCkRl7anv__4rulnpr8sgeL7tYdksvMQHPQ-gVtMH_2_J_wAvsO6Bg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1668049898</pqid></control><display><type>article</type><title>Pattern Separation: A Common Function for New Neurons in Hippocampus and Olfactory Bulb</title><source>MEDLINE</source><source>Cell Press Free Archives</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Sahay, Amar ; Wilson, Donald A. ; Hen, René</creator><creatorcontrib>Sahay, Amar ; Wilson, Donald A. ; Hen, René</creatorcontrib><description>While adult-born neurons in the olfactory bulb (OB) and the dentate gyrus (DG) subregion of the hippocampus have fundamentally different properties, they may have more in common than meets the eye. Here, we propose that new granule cells in the OB and DG may function as modulators of principal neurons to influence pattern separation and that adult neurogenesis constitutes an adaptive mechanism to optimally encode contextual or olfactory information. See the related Perspective from Aimone, Deng, and Gage, “Resolving New Memories: A Critical Look at the Dentate Gyrus, Adult Neurogenesis, and Pattern Separation,” in this issue of
Neuron.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/j.neuron.2011.05.012</identifier><identifier>PMID: 21609817</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Alzheimer's disease ; Animal cognition ; Animals ; Behavior ; Cell Differentiation - physiology ; Dentate gyrus ; Hippocampus - cytology ; Hippocampus - physiology ; Humans ; Nerve Net - cytology ; Nerve Net - physiology ; Neurogenesis ; Neurogenesis - physiology ; Neurons ; Neurons - cytology ; Neurons - physiology ; Odors ; Olfactory Bulb - cytology ; Olfactory Bulb - physiology ; Pattern recognition ; Studies</subject><ispartof>Neuron (Cambridge, Mass.), 2011-05, Vol.70 (4), p.582-588</ispartof><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited May 26, 2011</rights><rights>2011 Elsevier Inc. All rights reserved. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c588t-9258f4402d24ad8d2baefa78fe4905ee5cbd12164439f526f9c52e660b5efa343</citedby><cites>FETCH-LOGICAL-c588t-9258f4402d24ad8d2baefa78fe4905ee5cbd12164439f526f9c52e660b5efa343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S089662731100393X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21609817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sahay, Amar</creatorcontrib><creatorcontrib>Wilson, Donald A.</creatorcontrib><creatorcontrib>Hen, René</creatorcontrib><title>Pattern Separation: A Common Function for New Neurons in Hippocampus and Olfactory Bulb</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>While adult-born neurons in the olfactory bulb (OB) and the dentate gyrus (DG) subregion of the hippocampus have fundamentally different properties, they may have more in common than meets the eye. Here, we propose that new granule cells in the OB and DG may function as modulators of principal neurons to influence pattern separation and that adult neurogenesis constitutes an adaptive mechanism to optimally encode contextual or olfactory information. See the related Perspective from Aimone, Deng, and Gage, “Resolving New Memories: A Critical Look at the Dentate Gyrus, Adult Neurogenesis, and Pattern Separation,” in this issue of
Neuron.</description><subject>Alzheimer's disease</subject><subject>Animal cognition</subject><subject>Animals</subject><subject>Behavior</subject><subject>Cell Differentiation - physiology</subject><subject>Dentate gyrus</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - physiology</subject><subject>Humans</subject><subject>Nerve Net - cytology</subject><subject>Nerve Net - physiology</subject><subject>Neurogenesis</subject><subject>Neurogenesis - physiology</subject><subject>Neurons</subject><subject>Neurons - cytology</subject><subject>Neurons - physiology</subject><subject>Odors</subject><subject>Olfactory Bulb - cytology</subject><subject>Olfactory Bulb - physiology</subject><subject>Pattern recognition</subject><subject>Studies</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9vFSEUxYnR2NfqNzCGxIWrGYEBBlyY1JfWmjTWRI1LwjB3lJcZGGGmpt9eXl6tfxa6ICTc3z33cg5CTyipKaHyxa4OsKYYakYorYmoCWX30IYS3Vacan0fbYjSspKsbY7Qcc47QigXmj5ER4xKohVtN-jze7sskAL-ALNNdvExvMSneBunKQZ8vga3f8JDTPgdfC9nPzJjH_CFn-fo7DSvGdvQ46txsG6J6Qa_XsfuEXow2DHD49v7BH06P_u4vagur9683Z5eVk4otVSaCTVwTljPuO1VzzoLg23VAFwTASBc19OyLeeNHgSTg3aCgZSkE4VreHOCXh1057WboHcQlmRHMyc_2XRjovXmz0rwX82XeG2aYhRRogg8vxVI8dsKeTGTzw7G0QaIazaq5VQ1raL_J6VqpSxsIZ_9Re7imkLxwdBCEK6VVoXiB8qlmHOC4W5rSsw-YrMzh4jNPmJDhCkRl7anv__4rulnpr8sgeL7tYdksvMQHPQ-gVtMH_2_J_wAvsO6Bg</recordid><startdate>20110526</startdate><enddate>20110526</enddate><creator>Sahay, Amar</creator><creator>Wilson, Donald A.</creator><creator>Hen, René</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110526</creationdate><title>Pattern Separation: A Common Function for New Neurons in Hippocampus and Olfactory Bulb</title><author>Sahay, Amar ; Wilson, Donald A. ; Hen, René</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c588t-9258f4402d24ad8d2baefa78fe4905ee5cbd12164439f526f9c52e660b5efa343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Alzheimer's disease</topic><topic>Animal cognition</topic><topic>Animals</topic><topic>Behavior</topic><topic>Cell Differentiation - physiology</topic><topic>Dentate gyrus</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - physiology</topic><topic>Humans</topic><topic>Nerve Net - cytology</topic><topic>Nerve Net - physiology</topic><topic>Neurogenesis</topic><topic>Neurogenesis - physiology</topic><topic>Neurons</topic><topic>Neurons - cytology</topic><topic>Neurons - physiology</topic><topic>Odors</topic><topic>Olfactory Bulb - cytology</topic><topic>Olfactory Bulb - physiology</topic><topic>Pattern recognition</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sahay, Amar</creatorcontrib><creatorcontrib>Wilson, Donald A.</creatorcontrib><creatorcontrib>Hen, René</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sahay, Amar</au><au>Wilson, Donald A.</au><au>Hen, René</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pattern Separation: A Common Function for New Neurons in Hippocampus and Olfactory Bulb</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>2011-05-26</date><risdate>2011</risdate><volume>70</volume><issue>4</issue><spage>582</spage><epage>588</epage><pages>582-588</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>While adult-born neurons in the olfactory bulb (OB) and the dentate gyrus (DG) subregion of the hippocampus have fundamentally different properties, they may have more in common than meets the eye. Here, we propose that new granule cells in the OB and DG may function as modulators of principal neurons to influence pattern separation and that adult neurogenesis constitutes an adaptive mechanism to optimally encode contextual or olfactory information. See the related Perspective from Aimone, Deng, and Gage, “Resolving New Memories: A Critical Look at the Dentate Gyrus, Adult Neurogenesis, and Pattern Separation,” in this issue of
Neuron.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21609817</pmid><doi>10.1016/j.neuron.2011.05.012</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0896-6273 |
| ispartof | Neuron (Cambridge, Mass.), 2011-05, Vol.70 (4), p.582-588 |
| issn | 0896-6273 1097-4199 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3109085 |
| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Alzheimer's disease Animal cognition Animals Behavior Cell Differentiation - physiology Dentate gyrus Hippocampus - cytology Hippocampus - physiology Humans Nerve Net - cytology Nerve Net - physiology Neurogenesis Neurogenesis - physiology Neurons Neurons - cytology Neurons - physiology Odors Olfactory Bulb - cytology Olfactory Bulb - physiology Pattern recognition Studies |
| title | Pattern Separation: A Common Function for New Neurons in Hippocampus and Olfactory Bulb |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T00%3A10%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pattern%20Separation:%20A%20Common%20Function%20for%20New%20Neurons%20in%20Hippocampus%20and%20Olfactory%20Bulb&rft.jtitle=Neuron%20(Cambridge,%20Mass.)&rft.au=Sahay,%20Amar&rft.date=2011-05-26&rft.volume=70&rft.issue=4&rft.spage=582&rft.epage=588&rft.pages=582-588&rft.issn=0896-6273&rft.eissn=1097-4199&rft_id=info:doi/10.1016/j.neuron.2011.05.012&rft_dat=%3Cproquest_pubme%3E874183781%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1668049898&rft_id=info:pmid/21609817&rft_els_id=S089662731100393X&rfr_iscdi=true |