Use of an adult rat retinal explant model for screening of potential retinal ganglion cell neuroprotective therapies

PURPOSE. To validate an established adult organotypic retinal explant culture system for use as an efficient medium-throughput screening tool to investigate novel retinal ganglion cell (RGC) neuroprotective therapies. METHODS. Optimal culture conditions for detecting RGC neuroprotection in rat retin...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2011-05, Vol.52 (6), p.3309-3320
Hauptverfasser:	Bull, Natalie D, Johnson, Thomas V, Welsapar, Guncha, DeKorver, Nicholas W, Tomarev, Stanislav I, Martin, Keith R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Chloromethyl Ketones - pharmacology Animals Apoptosis - drug effects Brain-Derived Neurotrophic Factor - pharmacology Caspase Inhibitors Cell Survival - drug effects Cells, Cultured Coculture Techniques Colforsin - pharmacology Disease Models, Animal Drug Evaluation, Preclinical Male Mesenchymal Stromal Cells - cytology Nerve Crush Neuroprotective Agents - pharmacology Ocular Hypertension - prevention & control Optic Nerve Optic Nerve Diseases - prevention & control Organ Culture Techniques Rats Rats, Sprague-Dawley Retinal Ganglion Cells - cytology Retinal Ganglion Cells - physiology Stem Cell Transplantation
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