H2O2 Is the Transferrable Factor Mediating Flow-Induced Dilation in Human Coronary Arterioles

RATIONALE:Endothelial derived hydrogen peroxide (H2O2) is a necessary component of the pathway regulating flow-mediated dilation (FMD) in human coronary arterioles (HCAs). However, H2O2 has never been shown to be the endothelium-dependent transferrable hyperpolarization factor (EDHF) in response to...

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Veröffentlicht in:	Circulation research 2011-03, Vol.108 (5), p.566-573
Hauptverfasser:	Liu, Yanping, Bubolz, Aaron H, Mendoza, Suelhem, Zhang, David X, Gutterman, David D
Format:	Artikel
Sprache:	eng
Schlagworte:	Arterioles - drug effects Arterioles - physiology Biological and medical sciences Biological Factors - metabolism Catalase - metabolism Coronary Vessels - drug effects Coronary Vessels - physiology Endothelium, Vascular - metabolism Fundamental and applied biological sciences. Psychology Humans Hydrogen Peroxide - metabolism Hydrogen Peroxide - pharmacology Indoles - pharmacology Large-Conductance Calcium-Activated Potassium Channels - metabolism Muscle, Smooth, Vascular - metabolism Patch-Clamp Techniques Polyethylene Glycols - metabolism Potassium Channel Blockers - pharmacology Regional Blood Flow - physiology Vasodilation - drug effects Vasodilation - physiology Vertebrates: cardiovascular system
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