Iron Homeostasis and the Inflammatory Response
Iron and its homeostasis are intimately tied to the inflammatory response. The adaptation to iron deficiency, which confers resistance to infection and improves the inflammatory condition, underlies what is probably the most obvious link: the anemia of inflammation or chronic disease. A large number...
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| Veröffentlicht in: | Annual review of nutrition 2010-08, Vol.30 (1), p.105-122 |
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| creator | WESSLING-RESNICK, Marianne |
| description | Iron and its homeostasis are intimately tied to the inflammatory response. The adaptation to iron deficiency, which confers resistance to infection and improves the inflammatory condition, underlies what is probably the most obvious link: the anemia of inflammation or chronic disease. A large number of stimulatory inputs must be integrated to tightly control iron homeostasis during the inflammatory response. In order to understand the pathways of iron trafficking and how they are regulated, this article presents a brief overview of iron homeostasis. A major focus is on the regulation of the peptide hormone hepcidin during the inflammatory response and how its function contributes to the process of iron withdrawal. The review also summarizes new and emerging information about other iron metabolic regulators and effectors that contribute to the inflammatory response. Potential benefits of treatment to ameliorate the hypoferremic condition promoted by inflammation are also considered. |
| doi_str_mv | 10.1146/annurev.nutr.012809.104804 |
| format | Article |
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The adaptation to iron deficiency, which confers resistance to infection and improves the inflammatory condition, underlies what is probably the most obvious link: the anemia of inflammation or chronic disease. A large number of stimulatory inputs must be integrated to tightly control iron homeostasis during the inflammatory response. In order to understand the pathways of iron trafficking and how they are regulated, this article presents a brief overview of iron homeostasis. A major focus is on the regulation of the peptide hormone hepcidin during the inflammatory response and how its function contributes to the process of iron withdrawal. The review also summarizes new and emerging information about other iron metabolic regulators and effectors that contribute to the inflammatory response. Potential benefits of treatment to ameliorate the hypoferremic condition promoted by inflammation are also considered.</description><subject>Anemia, Iron-Deficiency - etiology</subject><subject>Anemia, Iron-Deficiency - metabolism</subject><subject>Antimicrobial Cationic Peptides - metabolism</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hepcidins</subject><subject>Homeostasis - physiology</subject><subject>Humans</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - physiopathology</subject><subject>Iron - deficiency</subject><subject>Iron - metabolism</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0199-9885</issn><issn>1545-4312</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkNtKxDAQhoMouh5eQYogXrXmuE28EEQ8LAiC6HWYplOttMmatIJvb2XX09VczPf_M3yEHDFaMCbnp-D9GPG98OMQC8q4pqZgVGoqN8iMKalyKRjfJDPKjMmN1mqH7Kb0Sik1QohtssOp5FRxOSPFIgaf3YYeQxogtSkDX2fDC2YL33TQ9zCE-JE9YFoGn3CfbDXQJTxYzz3ydH31eHmb393fLC4v7nKnOBtypSVgVToqpcT53NSVqZqmBsmN4NhUvGKcM9D1vMLKNFKhUo5LyUpRgzO12CPnq97lWPVYO_RDhM4uY9tD_LABWvt_49sX-xzerWB00lFOBSfrghjeRkyD7dvksOvAYxiTLYUwxpRaTuTZinQxpBSx-bnCqP3ybde-7Zdvu_JtV76n8OHfP3-i34In4HgNQHLQNRG8a9MvJ7g2RmjxCXjljoQ</recordid><startdate>20100821</startdate><enddate>20100821</enddate><creator>WESSLING-RESNICK, Marianne</creator><general>Annual Reviews</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100821</creationdate><title>Iron Homeostasis and the Inflammatory Response</title><author>WESSLING-RESNICK, Marianne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-584aeb7c0444e669db9bffda42932efb2b1221a8d6beb9f45e55c244173dac9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Anemia, Iron-Deficiency - etiology</topic><topic>Anemia, Iron-Deficiency - metabolism</topic><topic>Antimicrobial Cationic Peptides - metabolism</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hepcidins</topic><topic>Homeostasis - physiology</topic><topic>Humans</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - physiopathology</topic><topic>Iron - deficiency</topic><topic>Iron - metabolism</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WESSLING-RESNICK, Marianne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annual review of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WESSLING-RESNICK, Marianne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iron Homeostasis and the Inflammatory Response</atitle><jtitle>Annual review of nutrition</jtitle><addtitle>Annu Rev Nutr</addtitle><date>2010-08-21</date><risdate>2010</risdate><volume>30</volume><issue>1</issue><spage>105</spage><epage>122</epage><pages>105-122</pages><issn>0199-9885</issn><eissn>1545-4312</eissn><coden>ARNTD8</coden><abstract>Iron and its homeostasis are intimately tied to the inflammatory response. The adaptation to iron deficiency, which confers resistance to infection and improves the inflammatory condition, underlies what is probably the most obvious link: the anemia of inflammation or chronic disease. A large number of stimulatory inputs must be integrated to tightly control iron homeostasis during the inflammatory response. In order to understand the pathways of iron trafficking and how they are regulated, this article presents a brief overview of iron homeostasis. A major focus is on the regulation of the peptide hormone hepcidin during the inflammatory response and how its function contributes to the process of iron withdrawal. The review also summarizes new and emerging information about other iron metabolic regulators and effectors that contribute to the inflammatory response. 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| ispartof | Annual review of nutrition, 2010-08, Vol.30 (1), p.105-122 |
| issn | 0199-9885 1545-4312 |
| language | eng |
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| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | Anemia, Iron-Deficiency - etiology Anemia, Iron-Deficiency - metabolism Antimicrobial Cationic Peptides - metabolism Biological and medical sciences Chronic Disease Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Hepcidins Homeostasis - physiology Humans Inflammation - metabolism Inflammation - physiopathology Iron - deficiency Iron - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Iron Homeostasis and the Inflammatory Response |
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