Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2

Cdc2L1 and Cdc2L2 span approximately 140 kb on human chromosome 1p36.3. The products of the Cdc2L genes encode almost identical protein kinases, the PITSLRE kinases, which have functions that may be relevant to the regulation of transcription/splicing and apoptotic signaling. These genes are deleted...

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Veröffentlicht in:	Genome research 1998-09, Vol.8 (9), p.929-939
Hauptverfasser:	Gururajan, R, Lahti, J M, Grenet, J, Easton, J, Gruber, I, Ambros, P F, Kidd, V J
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions - genetics Alternative Splicing Bacteriophage P1 - genetics Chromosome Mapping Chromosomes, Human, Pair 1 - genetics Cloning, Molecular Cosmids - genetics Cyclin-Dependent Kinases DNA, Complementary - isolation & purification Gene Duplication Genes, Duplicate Genetic Linkage Genetic Markers - genetics Humans In Situ Hybridization, Fluorescence Letter Metalloendopeptidases - genetics Molecular Sequence Data Protein Kinases - genetics Protein Kinases - metabolism Protein Serine-Threonine Kinases Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, DNA Tumor Cells, Cultured
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