DNA methylation dysregulates and silences the HLA-DQ locus by altering chromatin architecture

The major histocompatibility complex class II (MHC-II) locus encodes a cluster of highly polymorphic genes HLA-DR , -DQ and - DP that are co-expressed in mature B lymphocytes. Two cell lines were established over 30 years ago from a patient diagnosed with acute lymphocytic leukemia. Laz221 represent...

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Veröffentlicht in:	Genes and immunity 2011-06, Vol.12 (4), p.291-299
Hauptverfasser:	Majumder, P, Boss, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/176/1988 631/250/21/324 631/80/304 692/699/67/1990/283/2125 Biomedical and Life Sciences Biomedicine Cancer Research CCCTC-Binding Factor Cell Line Cell receptors Chromatin Chromatin - genetics Chromatin - immunology CpG Islands DNA Methylation Epigenetics Gene Expression Gene Silencing Genetic aspects Genetic Loci Histocompatibility antigen HLA Histocompatibility antigens HLA histocompatibility antigens HLA-DQ Antigens - genetics HLA-DQ Antigens - immunology Human Genetics Humans Immunology Immunosurveillance Leukemia Lymphatic leukemia Lymphocytes Lymphocytes B Major histocompatibility complex Methylation original-article Patients Physiological aspects Promoter Regions, Genetic Proteins Repressor Proteins - metabolism Transcription factors Tumor cells
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