Nucleolar disruption and apoptosis are distinct neuronal responses to etoposide‐induced DNA damage

J. Neurochem. (2011) 117, 1033–1046. Although DNA damaging topoisomerase inhibitors induce apoptosis in developing neurons, their effects on adult neurons have not yet been characterized. We report a blockage of RNA‐Polymerase‐1‐driven transcription and nucleolar stress in neocortical neurons of adu...

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Veröffentlicht in:	Journal of neurochemistry 2011-06, Vol.117 (6), p.1033-1046
Hauptverfasser:	Pietrzak, Maciej, Smith, Scott C., Geralds, Justin T., Hagg, Theo, Gomes, Cynthia, Hetman, Michal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Age Factors Ageing, cell death Animals Animals, Newborn Antineoplastic Agents - administration & dosage Antineoplastic Agents - toxicity Apoptosis Ataxia Ataxia Telangiectasia Mutated Proteins Biological and medical sciences Brain Carotid Arteries Cell Cycle Proteins - metabolism Cell Nucleolus - drug effects Cell Nucleolus - ultrastructure Cell physiology Cells, Cultured Cerebral Cortex - cytology Chromosomes, Mammalian - genetics Cortex DNA Breaks, Double-Stranded DNA Damage DNA topoisomerase inhibitors DNA-Binding Proteins - metabolism Endonuclease Enzyme Activation Etoposide Etoposide - administration & dosage Etoposide - toxicity Fundamental and applied biological sciences. Psychology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Injections, Intra-Arterial Injections, Intraventricular Male Medical sciences Mice Molecular and cellular biology Neonates Nervous system (semeiology, syndromes) Neurochemistry neurodegeneration Neurology Neurons Neurons - drug effects Neurons - ultrastructure Neurotoxicity Nucleoli nucleolus p53 protein Protein kinase Protein-Serine-Threonine Kinases - metabolism Rats Rats, Sprague-Dawley ribosomal‐biogenesis RNA Polymerase I - physiology Rodents Stress Stress response Topoisomerase II Inhibitors - toxicity Transcription Transcription, Genetic Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins - metabolism
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