Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Adult neurogenesis, a process of generating functional neurons from adult neural precursors, occurs throughout life in restricted brain regions in mammals. The past decade has witnessed tremendous progress in addressing questions related to almost every aspect of adult neurogenesis in the mammalian...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2011-05, Vol.70 (4), p.687-702 |
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| creator | Ming, Guo-li Song, Hongjun |
| description | Adult neurogenesis, a process of generating functional neurons from adult neural precursors, occurs throughout life in restricted brain regions in mammals. The past decade has witnessed tremendous progress in addressing questions related to almost every aspect of adult neurogenesis in the mammalian brain. Here we review major advances in our understanding of adult mammalian neurogenesis in the dentate gyrus of the hippocampus and from the subventricular zone of the lateral ventricle, the rostral migratory stream to the olfactory bulb. We highlight emerging principles that have significant implications for stem cell biology, developmental neurobiology, neural plasticity, and disease mechanisms. We also discuss remaining questions related to adult neural stem cells and their niches, underlying regulatory mechanisms, and potential functions of newborn neurons in the adult brain. Building upon the recent progress and aided by new technologies, the adult neurogenesis field is poised to leap forward in the next decade. |
| doi_str_mv | 10.1016/j.neuron.2011.05.001 |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Age Factors Animals Brain - cytology Brain - physiology Brain research Cell division Humans Mammals Nervous System Diseases - pathology Nervous System Diseases - surgery Neural Stem Cells - cytology Neural Stem Cells - physiology Neural Stem Cells - transplantation Neurogenesis Neurogenesis - physiology Neuronal Plasticity - physiology Neurons Physiology Rodents Stem cells Studies |
| title | Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions |
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