CREB Is a Novel Nuclear Target of PTEN Phosphatase

PTEN phosphatase is a potent tumor suppressor that regulates multiple cellular functions. In the cytoplasm, PTEN dephosphorylates its primary lipid substrate, phosphatidylinositol 3,4,5-trisphosphate, to antagonize the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway. It has also become in...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2011-04, Vol.71 (8), p.2821-2825
Hauptverfasser:	Gu, Tingting, Zhang, Zhong, Wang, Jianli, Guo, Junyi, Shen, Wen Hong, Yin, Yuxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cell Growth Processes - physiology Cell Line, Tumor Cell Nucleus - enzymology Cell Nucleus - metabolism Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Gene Deletion Gene Expression Gene Knockdown Techniques Humans Medical sciences Mice Mice, Knockout Pharmacology. Drug treatments Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - deficiency PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Tumors Up-Regulation
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