Controlled interplay between trigger loop and Gre factor in the RNA polymerase active centre

The highly processive transcription by multi-subunit RNA polymerases (RNAP) can be interrupted by misincorporation or backtracking events that may stall transcription or lead to erroneous transcripts. Backtracked/misincorporated complexes can be resolved via hydrolysis of the transcript. Here, we sh...

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Veröffentlicht in:	Nucleic acids research 2011-05, Vol.39 (10), p.4352-4359
Hauptverfasser:	Roghanian, Mohammad, Yuzenkova, Yulia, Zenkin, Nikolay
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalytic Domain DNA-Directed RNA Polymerases - chemistry DNA-Directed RNA Polymerases - metabolism Hydrolysis Models, Molecular RNA Transcription Factors - metabolism Transcription, Genetic
Online-Zugang:	Volltext
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