Alcohol Consumption Over Time and Risk of Lymphoid Malignancies in the California Teachers Study Cohort
Several previous studies found inverse associations between alcohol consumption and risk of non-Hodgkin lymphoma (NHL) and multiple myeloma. However, most studies were retrospective, and few distinguished former drinkers or infrequent drinkers from consistent nondrinkers. Therefore, the authors inve...
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| Veröffentlicht in: | American journal of epidemiology 2010-12, Vol.172 (12), p.1373-1383 |
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| creator | Chang, Ellen T. Clarke, Christina A. Canchola, Alison J. Lu, Yani Wang, Sophia S. Ursin, Giske West, Dee W. Bernstein, Leslie Horn-Ross, Pamela L. |
| description | Several previous studies found inverse associations between alcohol consumption and risk of non-Hodgkin lymphoma (NHL) and multiple myeloma. However, most studies were retrospective, and few distinguished former drinkers or infrequent drinkers from consistent nondrinkers. Therefore, the authors investigated whether history of alcohol drinking affected risks of NHL and multiple myeloma among 102,721 eligible women in the California Teachers Study, a prospective cohort study in which 496 women were diagnosed with B-cell NHL and 101 were diagnosed with multiple myeloma between 1995–1996 and December 31, 2007. Incidence rate ratios and 95% confidence intervals were estimated using Cox proportional hazards regression. Risk of all types of B-cell NHL combined or multiple myeloma was not associated with self-reported past consumption of alcohol, beer, wine, or liquor at ages 18–22 years, at ages 30–35 years, or during the year before baseline. NHL subtypes were inconsistently associated with alcohol intake. However, women who were former alcohol drinkers at baseline were at elevated risk of overall B-cell NHL (rate ratio = 1.46, 95% confidence interval: 1.08, 1.97) and follicular lymphoma (rate ratio = 1.81, 95% confidence interval: 1.00, 3.28). The higher risk among former drinkers emphasizes the importance of classifying both current and past alcohol consumption and suggests that factors related to quitting drinking, rather than alcohol itself, may increase B-cell NHL risk. |
| doi_str_mv | 10.1093/aje/kwq309 |
| format | Article |
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However, most studies were retrospective, and few distinguished former drinkers or infrequent drinkers from consistent nondrinkers. Therefore, the authors investigated whether history of alcohol drinking affected risks of NHL and multiple myeloma among 102,721 eligible women in the California Teachers Study, a prospective cohort study in which 496 women were diagnosed with B-cell NHL and 101 were diagnosed with multiple myeloma between 1995–1996 and December 31, 2007. Incidence rate ratios and 95% confidence intervals were estimated using Cox proportional hazards regression. Risk of all types of B-cell NHL combined or multiple myeloma was not associated with self-reported past consumption of alcohol, beer, wine, or liquor at ages 18–22 years, at ages 30–35 years, or during the year before baseline. NHL subtypes were inconsistently associated with alcohol intake. However, women who were former alcohol drinkers at baseline were at elevated risk of overall B-cell NHL (rate ratio = 1.46, 95% confidence interval: 1.08, 1.97) and follicular lymphoma (rate ratio = 1.81, 95% confidence interval: 1.00, 3.28). The higher risk among former drinkers emphasizes the importance of classifying both current and past alcohol consumption and suggests that factors related to quitting drinking, rather than alcohol itself, may increase B-cell NHL risk.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwq309</identifier><identifier>PMID: 20952595</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Alcohol Drinking ; Alcoholism ; Biological and medical sciences ; California - epidemiology ; Cohort Studies ; Epidemiology ; Faculty ; Female ; General aspects ; Hematologic and hematopoietic diseases ; Humans ; Immunodeficiencies. Immunoglobulinopathies ; Immunoglobulinopathies ; Immunopathology ; Incidence ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphatic system ; Lymphoma ; Lymphoma, Non-Hodgkin - diagnosis ; Lymphoma, Non-Hodgkin - epidemiology ; Medical sciences ; Middle Aged ; Miscellaneous ; multiple myeloma ; Multiple Myeloma - diagnosis ; Multiple Myeloma - epidemiology ; non-Hodgkin ; Original Contributions ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Socioeconomic Factors ; Time Factors ; Vitaceae ; Women ; Young Adult</subject><ispartof>American journal of epidemiology, 2010-12, Vol.172 (12), p.1373-1383</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Dec 15, 2010</rights><rights>American Journal of Epidemiology © The Author 2010. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-5a1df96cc60f9012ffcd57fa52974fe052b7e226450180258ebf7fad7df56653</citedby><cites>FETCH-LOGICAL-c504t-5a1df96cc60f9012ffcd57fa52974fe052b7e226450180258ebf7fad7df56653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23711203$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20952595$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Ellen T.</creatorcontrib><creatorcontrib>Clarke, Christina A.</creatorcontrib><creatorcontrib>Canchola, Alison J.</creatorcontrib><creatorcontrib>Lu, Yani</creatorcontrib><creatorcontrib>Wang, Sophia S.</creatorcontrib><creatorcontrib>Ursin, Giske</creatorcontrib><creatorcontrib>West, Dee W.</creatorcontrib><creatorcontrib>Bernstein, Leslie</creatorcontrib><creatorcontrib>Horn-Ross, Pamela L.</creatorcontrib><title>Alcohol Consumption Over Time and Risk of Lymphoid Malignancies in the California Teachers Study Cohort</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>Several previous studies found inverse associations between alcohol consumption and risk of non-Hodgkin lymphoma (NHL) and multiple myeloma. However, most studies were retrospective, and few distinguished former drinkers or infrequent drinkers from consistent nondrinkers. Therefore, the authors investigated whether history of alcohol drinking affected risks of NHL and multiple myeloma among 102,721 eligible women in the California Teachers Study, a prospective cohort study in which 496 women were diagnosed with B-cell NHL and 101 were diagnosed with multiple myeloma between 1995–1996 and December 31, 2007. Incidence rate ratios and 95% confidence intervals were estimated using Cox proportional hazards regression. Risk of all types of B-cell NHL combined or multiple myeloma was not associated with self-reported past consumption of alcohol, beer, wine, or liquor at ages 18–22 years, at ages 30–35 years, or during the year before baseline. NHL subtypes were inconsistently associated with alcohol intake. However, women who were former alcohol drinkers at baseline were at elevated risk of overall B-cell NHL (rate ratio = 1.46, 95% confidence interval: 1.08, 1.97) and follicular lymphoma (rate ratio = 1.81, 95% confidence interval: 1.00, 3.28). The higher risk among former drinkers emphasizes the importance of classifying both current and past alcohol consumption and suggests that factors related to quitting drinking, rather than alcohol itself, may increase B-cell NHL risk.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alcohol Drinking</subject><subject>Alcoholism</subject><subject>Biological and medical sciences</subject><subject>California - epidemiology</subject><subject>Cohort Studies</subject><subject>Epidemiology</subject><subject>Faculty</subject><subject>Female</subject><subject>General aspects</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Incidence</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphatic system</subject><subject>Lymphoma</subject><subject>Lymphoma, Non-Hodgkin - diagnosis</subject><subject>Lymphoma, Non-Hodgkin - epidemiology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>multiple myeloma</subject><subject>Multiple Myeloma - diagnosis</subject><subject>Multiple Myeloma - epidemiology</subject><subject>non-Hodgkin</subject><subject>Original Contributions</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><subject>Socioeconomic Factors</subject><subject>Time Factors</subject><subject>Vitaceae</subject><subject>Women</subject><subject>Young Adult</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV2LEzEUhgdxcevqjT9AgiCCMG6SmSSTm4W1uh9QWboWFG9Cmkk6aWeSbjKz2n9vuq3148arA3kfHs7Jm2UvEHyHIC9O5VKfrr7fFZA_ykaoZDSnmNDH2QhCiHOOKT7Onsa4hBAhTuCT7BhDTjDhZJQtzlvlG9-CsXdx6Na99Q7c3OsAZrbTQLoa3Nq4At6AyaZbN97W4JNs7cJJp6yOwDrQNxqM05vxwVkJZlqqRocIPvdDvUnixof-WXZkZBv18_08yWYXH2fjq3xyc3k9Pp_kisCyz4lEteFUKQoNhwgbo2rCjCSYs9JoSPCcaYxpSSCqICaVnpsU16w2hFJSnGRnO-16mHe6Vtr1QbZiHWwnw0Z4acXfibONWPh7UaDkZlvBm70g-LtBx150NirdttJpP0RRMV6yAlXl_0lEGUclrxL56h9y6Yfg0jeI5Kkgqx42f7uDVPAxBm0OSyMotjWLVLPY1Zzgl3-eeUB_9ZqA13tARiVbE7Ztxd9cwRDCsEhcvuNs7PWPQy7DSlBWMCKuvn4TX6a3F--n1VR8KH4CD8vBJg</recordid><startdate>20101215</startdate><enddate>20101215</enddate><creator>Chang, Ellen T.</creator><creator>Clarke, Christina A.</creator><creator>Canchola, Alison J.</creator><creator>Lu, Yani</creator><creator>Wang, Sophia S.</creator><creator>Ursin, Giske</creator><creator>West, Dee W.</creator><creator>Bernstein, Leslie</creator><creator>Horn-Ross, Pamela L.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7U1</scope><scope>5PM</scope></search><sort><creationdate>20101215</creationdate><title>Alcohol Consumption Over Time and Risk of Lymphoid Malignancies in the California Teachers Study Cohort</title><author>Chang, Ellen T. ; Clarke, Christina A. ; Canchola, Alison J. ; Lu, Yani ; Wang, Sophia S. ; Ursin, Giske ; West, Dee W. ; Bernstein, Leslie ; Horn-Ross, Pamela L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-5a1df96cc60f9012ffcd57fa52974fe052b7e226450180258ebf7fad7df56653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alcohol Drinking</topic><topic>Alcoholism</topic><topic>Biological and medical sciences</topic><topic>California - epidemiology</topic><topic>Cohort Studies</topic><topic>Epidemiology</topic><topic>Faculty</topic><topic>Female</topic><topic>General aspects</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Incidence</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphatic system</topic><topic>Lymphoma</topic><topic>Lymphoma, Non-Hodgkin - diagnosis</topic><topic>Lymphoma, Non-Hodgkin - epidemiology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>multiple myeloma</topic><topic>Multiple Myeloma - diagnosis</topic><topic>Multiple Myeloma - epidemiology</topic><topic>non-Hodgkin</topic><topic>Original Contributions</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><topic>Socioeconomic Factors</topic><topic>Time Factors</topic><topic>Vitaceae</topic><topic>Women</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Ellen T.</creatorcontrib><creatorcontrib>Clarke, Christina A.</creatorcontrib><creatorcontrib>Canchola, Alison J.</creatorcontrib><creatorcontrib>Lu, Yani</creatorcontrib><creatorcontrib>Wang, Sophia S.</creatorcontrib><creatorcontrib>Ursin, Giske</creatorcontrib><creatorcontrib>West, Dee W.</creatorcontrib><creatorcontrib>Bernstein, Leslie</creatorcontrib><creatorcontrib>Horn-Ross, Pamela L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Ellen T.</au><au>Clarke, Christina A.</au><au>Canchola, Alison J.</au><au>Lu, Yani</au><au>Wang, Sophia S.</au><au>Ursin, Giske</au><au>West, Dee W.</au><au>Bernstein, Leslie</au><au>Horn-Ross, Pamela L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alcohol Consumption Over Time and Risk of Lymphoid Malignancies in the California Teachers Study Cohort</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>2010-12-15</date><risdate>2010</risdate><volume>172</volume><issue>12</issue><spage>1373</spage><epage>1383</epage><pages>1373-1383</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>Several previous studies found inverse associations between alcohol consumption and risk of non-Hodgkin lymphoma (NHL) and multiple myeloma. However, most studies were retrospective, and few distinguished former drinkers or infrequent drinkers from consistent nondrinkers. Therefore, the authors investigated whether history of alcohol drinking affected risks of NHL and multiple myeloma among 102,721 eligible women in the California Teachers Study, a prospective cohort study in which 496 women were diagnosed with B-cell NHL and 101 were diagnosed with multiple myeloma between 1995–1996 and December 31, 2007. Incidence rate ratios and 95% confidence intervals were estimated using Cox proportional hazards regression. Risk of all types of B-cell NHL combined or multiple myeloma was not associated with self-reported past consumption of alcohol, beer, wine, or liquor at ages 18–22 years, at ages 30–35 years, or during the year before baseline. NHL subtypes were inconsistently associated with alcohol intake. However, women who were former alcohol drinkers at baseline were at elevated risk of overall B-cell NHL (rate ratio = 1.46, 95% confidence interval: 1.08, 1.97) and follicular lymphoma (rate ratio = 1.81, 95% confidence interval: 1.00, 3.28). The higher risk among former drinkers emphasizes the importance of classifying both current and past alcohol consumption and suggests that factors related to quitting drinking, rather than alcohol itself, may increase B-cell NHL risk.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>20952595</pmid><doi>10.1093/aje/kwq309</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age Factors Aged Aged, 80 and over Alcohol Drinking Alcoholism Biological and medical sciences California - epidemiology Cohort Studies Epidemiology Faculty Female General aspects Hematologic and hematopoietic diseases Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Incidence Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic system Lymphoma Lymphoma, Non-Hodgkin - diagnosis Lymphoma, Non-Hodgkin - epidemiology Medical sciences Middle Aged Miscellaneous multiple myeloma Multiple Myeloma - diagnosis Multiple Myeloma - epidemiology non-Hodgkin Original Contributions Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Socioeconomic Factors Time Factors Vitaceae Women Young Adult |
| title | Alcohol Consumption Over Time and Risk of Lymphoid Malignancies in the California Teachers Study Cohort |
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