Radiosynthesis of antitumor spliceosome modulators

A set of novel antitumor agents (the sudemycins) has recently been described that are analogs of the natural product FR901464. We report the radiosynthesis of two of these antitumor drug lead compounds, using a three step procedure: (1) ester hydrolysis, (2) Lindlar's catalyst/tritium gas to gi...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Applied radiation and isotopes 2011-09, Vol.69 (9), p.1231-1234
Hauptverfasser:	Goronga, Tinopiwa, Boyd, Vincent A., Lagisetti, Chandraiah, Jeffries, Cynthia, Webb, Thomas R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkyne reduction Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antitumor Drug Design Isotope Labeling - methods Lindlar catalyst Pyrans - chemistry Spiro Compounds - chemistry Spliceosome Spliceosomes - drug effects Sudemycin Tritiation Tritium
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!