Uterine dysfunction and genetic modifiers in centromere protein B-deficient mice

Centromere protein B (CENP-B) binds constitutively to mammalian centromere repeat DNA and is highly conserved between humans and mouse. Cenpb null mice appear normal but have lower body and testis weights. We demonstrate here that testis-weight reduction is seen in male null mice generated on three...

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Veröffentlicht in:	Genome research 2000-01, Vol.10 (1), p.30-41
Hauptverfasser:	Fowler, K J, Hudson, D F, Salamonsen, L A, Edmondson, S R, Earle, E, Sibson, M C, Choo, K H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantigens Body Weight - genetics Cell Line Centromere - genetics Centromere Protein B Chimera - genetics Chromosomal Proteins, Non-Histone - biosynthesis Chromosomal Proteins, Non-Histone - deficiency DNA-Binding Proteins Epithelium - metabolism Epithelium - pathology Female Frameshift Mutation - genetics Humans Letter Male Mice Mice, Inbred C57BL Mice, Transgenic Mutagenesis, Site-Directed Organ Size - genetics Reproduction - genetics Testis - growth & development Testis - metabolism Uterus - abnormalities Uterus - growth & development
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