Relationship Between Residual Plasma Viremia and the Size of HIV Proviral DNA Reservoirs in Infected Individuals Receiving Effective Antiretroviral Therapy
Residual plasma viremia (
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| Veröffentlicht in: | The Journal of infectious diseases 2011-07, Vol.204 (1), p.135-138 |
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| container_issue | 1 |
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| container_title | The Journal of infectious diseases |
| container_volume | 204 |
| creator | Chun, Tae-Wook Murray, Danielle Justement, J. Shawn Hallahan, Claire W. Moir, Susan Kovacs, Colin Fauci, Anthony S. |
| description | Residual plasma viremia ( |
| doi_str_mv | 10.1093/infdis/jir208 |
| format | Article |
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Shawn ; Hallahan, Claire W. ; Moir, Susan ; Kovacs, Colin ; Fauci, Anthony S.</creator><creatorcontrib>Chun, Tae-Wook ; Murray, Danielle ; Justement, J. Shawn ; Hallahan, Claire W. ; Moir, Susan ; Kovacs, Colin ; Fauci, Anthony S.</creatorcontrib><description>Residual plasma viremia (<50 copies/mL) persists in certain human immunodeficiency virus (HIV)–infected individuals receiving antiretroviral therapy (ART); however, the relationship between the degree of residual plasma viremia, the size of HIV reservoirs, and the level of immune activation has not been delineated. Here, we demonstrate that residual plasma viremia correlates with the size of the CD4⁺ T cell viral reservoir, but not with markers of immune activation, suggesting that reactivation of the latent viral reservoir may not be the sole source of residual plasma viremia. Novel therapeutic strategies aimed at targeting the source of residual viremia may be necessary to achieve viral eradication.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jir208</identifier><identifier>PMID: 21628667</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Aged ; Anti-HIV Agents - administration & dosage ; Antiretroviral Therapy, Highly Active ; Antiretrovirals ; Arts ; Biological and medical sciences ; Blood plasma ; CD4-Positive T-Lymphocytes - immunology ; DNA ; DNA, Viral - blood ; Female ; Fundamental and applied biological sciences. Psychology ; HIV ; HIV - immunology ; HIV - isolation & purification ; HIV Infections - drug therapy ; HIV Infections - immunology ; HIV Infections - virology ; HIV/AIDS ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Major and Brief Reports ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Plasma - virology ; Polymerase chain reaction ; Proviruses - isolation & purification ; RNA ; Statistical median ; Stem cells ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viremia</subject><ispartof>The Journal of infectious diseases, 2011-07, Vol.204 (1), p.135-138</ispartof><rights>Copyright © 2011 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2011. 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-f39d86db9660d61597d5bf17089b786b0e53d997a159b805066678134e66eff83</citedby><cites>FETCH-LOGICAL-c570t-f39d86db9660d61597d5bf17089b786b0e53d997a159b805066678134e66eff83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41230375$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41230375$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,1584,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24310541$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21628667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chun, Tae-Wook</creatorcontrib><creatorcontrib>Murray, Danielle</creatorcontrib><creatorcontrib>Justement, J. Shawn</creatorcontrib><creatorcontrib>Hallahan, Claire W.</creatorcontrib><creatorcontrib>Moir, Susan</creatorcontrib><creatorcontrib>Kovacs, Colin</creatorcontrib><creatorcontrib>Fauci, Anthony S.</creatorcontrib><title>Relationship Between Residual Plasma Viremia and the Size of HIV Proviral DNA Reservoirs in Infected Individuals Receiving Effective Antiretroviral Therapy</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Residual plasma viremia (<50 copies/mL) persists in certain human immunodeficiency virus (HIV)–infected individuals receiving antiretroviral therapy (ART); however, the relationship between the degree of residual plasma viremia, the size of HIV reservoirs, and the level of immune activation has not been delineated. Here, we demonstrate that residual plasma viremia correlates with the size of the CD4⁺ T cell viral reservoir, but not with markers of immune activation, suggesting that reactivation of the latent viral reservoir may not be the sole source of residual plasma viremia. Novel therapeutic strategies aimed at targeting the source of residual viremia may be necessary to achieve viral eradication.</description><subject>Adult</subject><subject>Aged</subject><subject>Anti-HIV Agents - administration & dosage</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Antiretrovirals</subject><subject>Arts</subject><subject>Biological and medical sciences</subject><subject>Blood plasma</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>DNA</subject><subject>DNA, Viral - blood</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV</subject><subject>HIV - immunology</subject><subject>HIV - isolation & purification</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - virology</subject><subject>HIV/AIDS</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Major and Brief Reports</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Plasma - virology</subject><subject>Polymerase chain reaction</subject><subject>Proviruses - isolation & purification</subject><subject>RNA</subject><subject>Statistical median</subject><subject>Stem cells</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viremia</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhSMEokvhyBHkC4JLqB0ndnxBWtpCV6qgKqXXyInHXa-ydrCTVOWv8GdxyHaBC5w81vvmzYxekjwn-C3Bgh4Zq5UJRxvjM1w-SBakoDxljNCHyQLjLEtJKcRB8iSEDcY4p4w_Tg4ywrKSMb5IflxCK3vjbFibDr2H_hbAoksIRg2yRRetDFuJro2HrZFIWoX6NaAv5jsgp9HZ6hpdeDcaH9mTT8upEfzojA_IWLSyGpoeVCyUGX85hog0ED_2Bp3qSTYjoKXt44T-3ulqDV52d0-TRzp2wLPde5h8_XB6dXyWnn_-uDpenqdNwXGfaipUyVQtGMOKkUJwVdSacFyKmpesxlBQJQSXUapLXGAWLy8JzYEx0Lqkh8m72bcb6i2oBmwft6g6b7bS31VOmupvxZp1dePGipLoRvNo8Hpn4N23AUJfbU1ooG2lBTeEqmSCCyYIj-Sbf5KEs4xylhcTms5o410IHvR-IYKrKfpqjr6ao4_8yz-v2NP3WUfg1Q6QoZGt9tI2sX3P5dM5Ofm9oxu6_858MaOb0Du_h3OSUUx5QX8CtHzS6g</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Chun, Tae-Wook</creator><creator>Murray, Danielle</creator><creator>Justement, J. 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Psychology</topic><topic>HIV</topic><topic>HIV - immunology</topic><topic>HIV - isolation & purification</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - virology</topic><topic>HIV/AIDS</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Major and Brief Reports</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Plasma - virology</topic><topic>Polymerase chain reaction</topic><topic>Proviruses - isolation & purification</topic><topic>RNA</topic><topic>Statistical median</topic><topic>Stem cells</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. 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Here, we demonstrate that residual plasma viremia correlates with the size of the CD4⁺ T cell viral reservoir, but not with markers of immune activation, suggesting that reactivation of the latent viral reservoir may not be the sole source of residual plasma viremia. Novel therapeutic strategies aimed at targeting the source of residual viremia may be necessary to achieve viral eradication.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>21628667</pmid><doi>10.1093/infdis/jir208</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 2011-07, Vol.204 (1), p.135-138 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3105034 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Aged Anti-HIV Agents - administration & dosage Antiretroviral Therapy, Highly Active Antiretrovirals Arts Biological and medical sciences Blood plasma CD4-Positive T-Lymphocytes - immunology DNA DNA, Viral - blood Female Fundamental and applied biological sciences. Psychology HIV HIV - immunology HIV - isolation & purification HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV/AIDS Human immunodeficiency virus Human viral diseases Humans Infectious diseases Major and Brief Reports Male Medical sciences Microbiology Middle Aged Plasma - virology Polymerase chain reaction Proviruses - isolation & purification RNA Statistical median Stem cells Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viremia |
| title | Relationship Between Residual Plasma Viremia and the Size of HIV Proviral DNA Reservoirs in Infected Individuals Receiving Effective Antiretroviral Therapy |
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