Structural basis of G protein–coupled receptor–G protein interactions

Crosslinks between the active and inactive M3R and the G-protein G q to which it couples reveal GPCR-G protein movements that can occur upon agonist binding and define basic architectural features of the interface. The interaction of G protein–coupled receptors (GPCRs) with heterotrimeric G proteins...

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Veröffentlicht in:	Nature chemical biology 2010-07, Vol.6 (7), p.541-548
Hauptverfasser:	Hu, Jianxin, Wess, Jürgen, Wang, Yan, Zhang, Xiaohong, Lloyd, John R, Li, Jian Hua, Karpiak, Joel, Costanzi, Stefano
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/535 631/57/2272/2273 631/92/612/194 Amino Acid Sequence Amino Acid Substitution Biochemical Engineering Biochemistry Bioorganic Chemistry Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science GTP-Binding Protein alpha Subunits - chemistry GTP-Binding Protein alpha Subunits - genetics GTP-Binding Protein alpha Subunits - metabolism Immunoprecipitation Mass Spectrometry Models, Molecular Molecular biology Mutation Neurons Protein Binding Protein Conformation Proteins Receptors, Muscarinic - chemistry Receptors, Muscarinic - genetics Receptors, Muscarinic - metabolism
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