Combination of N-(4-hydroxyphenyl) retinamide and genistein increased apoptosis in neuroblastoma SK-N-BE2 and SH-SY5Y xenografts

Abstract Neuroblastoma is the childhood malignancy that mainly occurs in adrenal glands and is found also in the neck, chest, abdomen, and pelvis. New therapeutic strategies are urgently needed for successful treatment of this pediatric cancer. In this investigation, we examined efficacy of the reti...

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Veröffentlicht in:	Neuroscience 2009-09, Vol.163 (1), p.286-295
Hauptverfasser:	Karmakar, S, Roy Choudhury, S, Banik, N.L, Ray, S.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticarcinogenic Agents - pharmacology Anticarcinogenic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use apoptosis Apoptosis - drug effects Apoptosis - physiology Apoptosis Regulatory Proteins - drug effects Apoptosis Regulatory Proteins - metabolism Baculovirus Body Weight - drug effects caspases Cell Line, Tumor Cell Proliferation - drug effects Disease Models, Animal genistein Genistein - therapeutic use Humans Intercellular Signaling Peptides and Proteins - metabolism Mice Mice, Nude N-(4-hydroxyphenyl) retinamide neuroblastoma Neuroblastoma - drug therapy Neuroblastoma - metabolism Neuroblastoma - physiopathology Neurology NF-kappa B - drug effects NF-kappa B - metabolism Transplantation, Heterologous Treatment Outcome Tretinoin - analogs & derivatives Tretinoin - therapeutic use Tumor Cells, Cultured Xenograft Model Antitumor Assays
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