microRNAs： Fad or future of liver disease
microRNAs （miRs） are small non-coding RNAs that regulate both mRNA and protein expression of target genes, which results in alterations in mRNA stability or translation inhibition, miRs influence at least one third of all human transcripts and are known regulators of various important cellular growt...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2011-05, Vol.17 (20), p.2536-2542 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Lakner, Ashley M Bonkovsky, Herbert L Schrum, Laura W |
| description | microRNAs （miRs） are small non-coding RNAs that regulate both mRNA and protein expression of target genes, which results in alterations in mRNA stability or translation inhibition, miRs influence at least one third of all human transcripts and are known regulators of various important cellular growth and differentiation factors, miRs have recently emerged as key regulatory molecules in chronic liver disease. This review details recent contributions to the field of miRs that influence liver development and the broad spectrum of disease, from non-alcoholic fatty liver disease to fibrosis/cirrhosis, with particular emphasis on hepatic stellate cells and potential use of miRs as therapeutic tools. |
| doi_str_mv | 10.3748/wjg.v17.i20.2536 |
| format | Article |
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| identifier | ISSN: 1007-9327 |
| ispartof | World journal of gastroenterology : WJG, 2011-05, Vol.17 (20), p.2536-2542 |
| issn | 1007-9327 2219-2840 |
| language | eng |
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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals FAD Fatty Liver - physiopathology Humans Liver Cirrhosis - physiopathology Liver Diseases - drug therapy Liver Diseases - physiopathology Liver Regeneration - physiology MicroRNAs - physiology MicroRNAs - therapeutic use mRNA Non-alcoholic Fatty Liver Disease Topic Highlight 小分子RNA 细胞调节 肝星状细胞 肝脏疾病 蛋白表达 非编码RNA |
| title | microRNAs： Fad or future of liver disease |
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