Biocompatible and pH-Sensitive PLGA Encapsulated MnO Nanocrystals for Molecular and Cellular MRI
Inorganic manganese-based particles are becoming attractive for molecular and cellular imaging, due to their ability to provide bright contrast on MRI, as opposed to the dark contrast generated from iron-based particles. Using a single emulsion technique, we have successfully fabricated pH-sensitive...
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| Veröffentlicht in: | ACS nano 2011-05, Vol.5 (5), p.3438-3446 |
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| creator | Bennewitz, Margaret F Lobo, Tricia L Nkansah, Michael K Ulas, Gözde Brudvig, Gary W Shapiro, Erik M |
| description | Inorganic manganese-based particles are becoming attractive for molecular and cellular imaging, due to their ability to provide bright contrast on MRI, as opposed to the dark contrast generated from iron-based particles. Using a single emulsion technique, we have successfully fabricated pH-sensitive poly(lactic-co-glycolic acid) (PLGA)-encapsulated manganese oxide (MnO) nanocrystals. Two classes of particles were fabricated at ∼140 nm and 1.7 μm and incorporated 15 to 20 nm MnO nanocrystals with high encapsulation efficiencies. Intact particles at physiological pH cause little contrast in MRI, but following endocytosis into low pH compartments within the cells, the particles erode and MnO dissolves to release Mn2+. This causes the cells to appear bright on MR images. The magnitude of the change in MRI properties is as high as 35-fold, making it the most dynamic “smart” MRI contrast agent yet reported. Possible applications of these MnO particles include slow release Mn2+, tumor targeting, and confirmation of cell uptake. |
| doi_str_mv | 10.1021/nn1019779 |
| format | Article |
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Using a single emulsion technique, we have successfully fabricated pH-sensitive poly(lactic-co-glycolic acid) (PLGA)-encapsulated manganese oxide (MnO) nanocrystals. Two classes of particles were fabricated at ∼140 nm and 1.7 μm and incorporated 15 to 20 nm MnO nanocrystals with high encapsulation efficiencies. Intact particles at physiological pH cause little contrast in MRI, but following endocytosis into low pH compartments within the cells, the particles erode and MnO dissolves to release Mn2+. This causes the cells to appear bright on MR images. The magnitude of the change in MRI properties is as high as 35-fold, making it the most dynamic “smart” MRI contrast agent yet reported. Possible applications of these MnO particles include slow release Mn2+, tumor targeting, and confirmation of cell uptake.</description><identifier>ISSN: 1936-0851</identifier><identifier>EISSN: 1936-086X</identifier><identifier>DOI: 10.1021/nn1019779</identifier><identifier>PMID: 21495676</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Biocompatible Materials - chemical synthesis ; Cell Line, Tumor ; Cell Tracking - methods ; Contrast Media - chemical synthesis ; Contrast Media - pharmacokinetics ; Glioblastoma - metabolism ; Glioblastoma - pathology ; Humans ; Hydrogen-Ion Concentration ; Lactic Acid - chemistry ; Manganese Compounds - pharmacokinetics ; Nanostructures - chemistry ; Oxides - pharmacokinetics ; Polyglycolic Acid - chemistry</subject><ispartof>ACS nano, 2011-05, Vol.5 (5), p.3438-3446</ispartof><rights>Copyright © 2011 American Chemical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a470t-374a8f6dd5902bc53ab42f3d4017e1e748bb2523f02ee58f9b80b74109f7d2d63</citedby><cites>FETCH-LOGICAL-a470t-374a8f6dd5902bc53ab42f3d4017e1e748bb2523f02ee58f9b80b74109f7d2d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/nn1019779$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/nn1019779$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>230,314,776,780,881,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21495676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bennewitz, Margaret F</creatorcontrib><creatorcontrib>Lobo, Tricia L</creatorcontrib><creatorcontrib>Nkansah, Michael K</creatorcontrib><creatorcontrib>Ulas, Gözde</creatorcontrib><creatorcontrib>Brudvig, Gary W</creatorcontrib><creatorcontrib>Shapiro, Erik M</creatorcontrib><title>Biocompatible and pH-Sensitive PLGA Encapsulated MnO Nanocrystals for Molecular and Cellular MRI</title><title>ACS nano</title><addtitle>ACS Nano</addtitle><description>Inorganic manganese-based particles are becoming attractive for molecular and cellular imaging, due to their ability to provide bright contrast on MRI, as opposed to the dark contrast generated from iron-based particles. Using a single emulsion technique, we have successfully fabricated pH-sensitive poly(lactic-co-glycolic acid) (PLGA)-encapsulated manganese oxide (MnO) nanocrystals. Two classes of particles were fabricated at ∼140 nm and 1.7 μm and incorporated 15 to 20 nm MnO nanocrystals with high encapsulation efficiencies. Intact particles at physiological pH cause little contrast in MRI, but following endocytosis into low pH compartments within the cells, the particles erode and MnO dissolves to release Mn2+. This causes the cells to appear bright on MR images. The magnitude of the change in MRI properties is as high as 35-fold, making it the most dynamic “smart” MRI contrast agent yet reported. Possible applications of these MnO particles include slow release Mn2+, tumor targeting, and confirmation of cell uptake.</description><subject>Biocompatible Materials - chemical synthesis</subject><subject>Cell Line, Tumor</subject><subject>Cell Tracking - methods</subject><subject>Contrast Media - chemical synthesis</subject><subject>Contrast Media - pharmacokinetics</subject><subject>Glioblastoma - metabolism</subject><subject>Glioblastoma - pathology</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Lactic Acid - chemistry</subject><subject>Manganese Compounds - pharmacokinetics</subject><subject>Nanostructures - chemistry</subject><subject>Oxides - pharmacokinetics</subject><subject>Polyglycolic Acid - chemistry</subject><issn>1936-0851</issn><issn>1936-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1Lw0AQhhdRbK0e_AOyFw8eovuRZJOLoKW2hdaKH-Bt3eyHpqS7YTct9N8bWy0KwsDMMM-8w7wAnGJ0iRHBV9ZihHPG8j3QxTlNI5Slr_u7OsEdcBTCHKGEZSw9BB2C4zxJWdoFb7elk25Ri6YsKg2FVbAeRU_ahrIpVxo-TIY3cGClqMOyEo1WcGpn8F5YJ_06NKIK0DgPp67SsgX8RqGvq2rTTB_Hx-DAtJQ--c498HI3eO6PoslsOO7fTCIRM9RElMUiM6lSSY5IIRMqipgYqmKEmcaaxVlRkIRQg4jWSWbyIkMFizHKDVNEpbQHrre69bJYaCW1bbyoeO3LhfBr7kTJ_05s-cHf3YrT1kLaRg9cbAWkdyF4bXa7GPEvm_nO5pY9-31sR_742gLnW0DIwOdu6W37-z9Cn-a-hNc</recordid><startdate>20110524</startdate><enddate>20110524</enddate><creator>Bennewitz, Margaret F</creator><creator>Lobo, Tricia L</creator><creator>Nkansah, Michael K</creator><creator>Ulas, Gözde</creator><creator>Brudvig, Gary W</creator><creator>Shapiro, Erik M</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20110524</creationdate><title>Biocompatible and pH-Sensitive PLGA Encapsulated MnO Nanocrystals for Molecular and Cellular MRI</title><author>Bennewitz, Margaret F ; Lobo, Tricia L ; Nkansah, Michael K ; Ulas, Gözde ; Brudvig, Gary W ; Shapiro, Erik M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a470t-374a8f6dd5902bc53ab42f3d4017e1e748bb2523f02ee58f9b80b74109f7d2d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Biocompatible Materials - chemical synthesis</topic><topic>Cell Line, Tumor</topic><topic>Cell Tracking - methods</topic><topic>Contrast Media - chemical synthesis</topic><topic>Contrast Media - pharmacokinetics</topic><topic>Glioblastoma - metabolism</topic><topic>Glioblastoma - pathology</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Lactic Acid - chemistry</topic><topic>Manganese Compounds - pharmacokinetics</topic><topic>Nanostructures - chemistry</topic><topic>Oxides - pharmacokinetics</topic><topic>Polyglycolic Acid - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bennewitz, Margaret F</creatorcontrib><creatorcontrib>Lobo, Tricia L</creatorcontrib><creatorcontrib>Nkansah, Michael K</creatorcontrib><creatorcontrib>Ulas, Gözde</creatorcontrib><creatorcontrib>Brudvig, Gary W</creatorcontrib><creatorcontrib>Shapiro, Erik M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>ACS nano</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bennewitz, Margaret F</au><au>Lobo, Tricia L</au><au>Nkansah, Michael K</au><au>Ulas, Gözde</au><au>Brudvig, Gary W</au><au>Shapiro, Erik M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biocompatible and pH-Sensitive PLGA Encapsulated MnO Nanocrystals for Molecular and Cellular MRI</atitle><jtitle>ACS nano</jtitle><addtitle>ACS Nano</addtitle><date>2011-05-24</date><risdate>2011</risdate><volume>5</volume><issue>5</issue><spage>3438</spage><epage>3446</epage><pages>3438-3446</pages><issn>1936-0851</issn><eissn>1936-086X</eissn><abstract>Inorganic manganese-based particles are becoming attractive for molecular and cellular imaging, due to their ability to provide bright contrast on MRI, as opposed to the dark contrast generated from iron-based particles. 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| source | ACS Publications; MEDLINE |
| subjects | Biocompatible Materials - chemical synthesis Cell Line, Tumor Cell Tracking - methods Contrast Media - chemical synthesis Contrast Media - pharmacokinetics Glioblastoma - metabolism Glioblastoma - pathology Humans Hydrogen-Ion Concentration Lactic Acid - chemistry Manganese Compounds - pharmacokinetics Nanostructures - chemistry Oxides - pharmacokinetics Polyglycolic Acid - chemistry |
| title | Biocompatible and pH-Sensitive PLGA Encapsulated MnO Nanocrystals for Molecular and Cellular MRI |
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